The potential anxiolytic activity of GR38032F, a 5‐HT 3 ‐receptor antagonist

The potential anxiolytic activity of GR38032F, a 5‐HT 3 ‐receptor antagonist 1 The highly selective 5‐HT3‐receptor antagonist, GR38032F, has been tested in five animal models predictive for anxiolytic activity. 2 In the social interaction test in the rat and in a light/dark exploration test in the mouse, GR38032F dose‐dependently released suppressed behaviour without modifying locomotor activity. 3 In the cynomolgus monkey and the marmoset, GR38032F reduced anxiety‐related symptoms without causing sedation. In the marmoset, the effects were clearly dose‐related. 4 GR38032F did not have any detectable activity in the water‐lick conflict test in the rat. 5 We conclude that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

The potential anxiolytic activity of GR38032F, a 5‐HT 3 ‐receptor antagonist

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Publisher
Wiley
Copyright
1988 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1988.tb11489.x
Publisher site
See Article on Publisher Site

Abstract

1 The highly selective 5‐HT3‐receptor antagonist, GR38032F, has been tested in five animal models predictive for anxiolytic activity. 2 In the social interaction test in the rat and in a light/dark exploration test in the mouse, GR38032F dose‐dependently released suppressed behaviour without modifying locomotor activity. 3 In the cynomolgus monkey and the marmoset, GR38032F reduced anxiety‐related symptoms without causing sedation. In the marmoset, the effects were clearly dose‐related. 4 GR38032F did not have any detectable activity in the water‐lick conflict test in the rat. 5 We conclude that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity.

Journal

British Journal of PharmacologyWiley

Published: Apr 1, 1988

References

  • Pharmacological properties of GR38032F, a novel antagonist at 5‐HT 3 receptors
    BUTLER, BUTLER; HILL, HILL; IRELAND, IRELAND; JORDAN, JORDAN; TYERS, TYERS
  • Can social interaction be used to measure anxiety?
    FILE, FILE; HYDE, HYDE
  • A simple and reliable conflict procedure for testing anti‐anxiety agents
    VOGEL, VOGEL; BEER, BEER; CLODY, CLODY

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