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The pathophysiology of brain ischemia

The pathophysiology of brain ischemia Brain ischemia due to a critical reduction in cerebral blood flow is a well recognized and common cause of irreversible brain damage. The observation that brain cells are more resistant to ischemia than was previously assumed on the basis of clinical experience has stimulated considerable investigative work designed to determine those factors responsible for irreversible ischemic cell damage. At this time, data from these investigations indicate that cellular acidosis and biochemical disturbances initiated by abnormal intracellular ion homeostasis may be especially important in determining the ultimate survival of nerve cells. This review examines the biochemical events initiated by ischemia and their potential role in determining the ultimate survival of brain cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

The pathophysiology of brain ischemia

Annals of Neurology , Volume 13 (1) – Jan 1, 1983

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References (67)

Publisher
Wiley
Copyright
Copyright © 1983 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410130103
pmid
6299175
Publisher site
See Article on Publisher Site

Abstract

Brain ischemia due to a critical reduction in cerebral blood flow is a well recognized and common cause of irreversible brain damage. The observation that brain cells are more resistant to ischemia than was previously assumed on the basis of clinical experience has stimulated considerable investigative work designed to determine those factors responsible for irreversible ischemic cell damage. At this time, data from these investigations indicate that cellular acidosis and biochemical disturbances initiated by abnormal intracellular ion homeostasis may be especially important in determining the ultimate survival of nerve cells. This review examines the biochemical events initiated by ischemia and their potential role in determining the ultimate survival of brain cells.

Journal

Annals of NeurologyWiley

Published: Jan 1, 1983

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