The pathophysiology of brain ischemia

The pathophysiology of brain ischemia Brain ischemia due to a critical reduction in cerebral blood flow is a well recognized and common cause of irreversible brain damage. The observation that brain cells are more resistant to ischemia than was previously assumed on the basis of clinical experience has stimulated considerable investigative work designed to determine those factors responsible for irreversible ischemic cell damage. At this time, data from these investigations indicate that cellular acidosis and biochemical disturbances initiated by abnormal intracellular ion homeostasis may be especially important in determining the ultimate survival of nerve cells. This review examines the biochemical events initiated by ischemia and their potential role in determining the ultimate survival of brain cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

The pathophysiology of brain ischemia

Annals of Neurology, Volume 13 (1) – Jan 1, 1983

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Publisher
Wiley
Copyright
Copyright © 1983 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
D.O.I.
10.1002/ana.410130103
Publisher site
See Article on Publisher Site

Abstract

Brain ischemia due to a critical reduction in cerebral blood flow is a well recognized and common cause of irreversible brain damage. The observation that brain cells are more resistant to ischemia than was previously assumed on the basis of clinical experience has stimulated considerable investigative work designed to determine those factors responsible for irreversible ischemic cell damage. At this time, data from these investigations indicate that cellular acidosis and biochemical disturbances initiated by abnormal intracellular ion homeostasis may be especially important in determining the ultimate survival of nerve cells. This review examines the biochemical events initiated by ischemia and their potential role in determining the ultimate survival of brain cells.

Journal

Annals of NeurologyWiley

Published: Jan 1, 1983

References

  • Local cerebral glucose metabolism in newborn dogs: effects of hypoxia and halothane anesthesia
    Duffy, Duffy; Cavazzuti, Cavazzuti; Cruz, Cruz; Sokoloff, Sokoloff
  • Diffuse cerebral ischemia in the cat: I. Local blood flow during severe ischemia and recirculation
    Ginsberg, Ginsberg; Budd, Budd; Welsh, Welsh
  • Cerebral blood flow and oxygen consumption in the newborn dog
    Hernandez, Hernandez; Brennan, Brennan; Vannucci, Vannucci; Bowman, Bowman
  • Brain metabolism after 30 minutes of hypoxic or anoxic perfusion or ischemia
    Kintner, Kintner; Costello, Costello; Levin, Levin; Gilboe, Gilboe
  • Brain energy metabolism during and after cardiopulmonary resuscitation
    Nilsson, Nilsson; Busto, Busto
  • Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture
    Schlaepfer, Schlaepfer; Bunge, Bunge
  • Incomplete versus complete cerebral ischemia: improved outcome with a minimal blood flow
    Steen, Steen; Michenfelder, Michenfelder; Milde, Milde

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