The pathogenesis of acute laminitis: fitting more pieces into the puzzle

The pathogenesis of acute laminitis: fitting more pieces into the puzzle The condition of acute laminitis continues to be one of the most commonly presented and frustrating conditions to manage in equine medicine, causing pain and debilitation for a significant percentage of the domestic equine population at any one time (Anon 2000). There is a pressing need for the development of more effective means of prevention and treatment but, at present, there remains some uncertainty as to the exact chain of events making up the pathophysiology of the condition. Nevertheless, this is a fast moving field of research in which a large amount of recent work has improved our understanding of this disease. For example, studies of protein expression and mRNA levels within cells are now enabling the earliest functional changes within the cells of the lamellae to be determined, better defining the chain of events in the digit brought about by the circulating trigger factor(s). Although these trigger factors are yet to be definitively identified, several new potential candidates have been proposed. It is hoped that, through better understanding of pathogenic mechanisms, more effective ways can be found of limiting the damage to lamellar tissues, affected animals can be identified at an early stage and, ultimately, that the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

The pathogenesis of acute laminitis: fitting more pieces into the puzzle

Equine Veterinary Journal, Volume 36 (3) – Jan 1, 2004

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Publisher
Wiley
Copyright
Copyright © 2004 Wiley Subscription Services
ISSN
0425-1644
eISSN
2042-3306
DOI
10.2746/0425164044877251
Publisher site
See Article on Publisher Site

Abstract

The condition of acute laminitis continues to be one of the most commonly presented and frustrating conditions to manage in equine medicine, causing pain and debilitation for a significant percentage of the domestic equine population at any one time (Anon 2000). There is a pressing need for the development of more effective means of prevention and treatment but, at present, there remains some uncertainty as to the exact chain of events making up the pathophysiology of the condition. Nevertheless, this is a fast moving field of research in which a large amount of recent work has improved our understanding of this disease. For example, studies of protein expression and mRNA levels within cells are now enabling the earliest functional changes within the cells of the lamellae to be determined, better defining the chain of events in the digit brought about by the circulating trigger factor(s). Although these trigger factors are yet to be definitively identified, several new potential candidates have been proposed. It is hoped that, through better understanding of pathogenic mechanisms, more effective ways can be found of limiting the damage to lamellar tissues, affected animals can be identified at an early stage and, ultimately, that the

Journal

Equine Veterinary JournalWiley

Published: Jan 1, 2004

References

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