(wileyonlinelibrary.com) DOI 10.1002/jms.4001
The ongoing evolution of laser desorption/ionization mass spectrometry: Some observations on current
trends and future directions
By Manikandan Muthu, Sechul Chun, Hui‐Fen Wu, Mark W. Duncan and Judy Gopal
The full featured article is available at http://onlinelibrary.wiley.com/doi/10.1002/jms.4083/pdf
Volume 53 Number 6
The special feature in this issue of the Journal explores trends, challenges and opportunities in the broad area of laser desorption/
ionization (LDI) mass spectrometry. The authors discuss the potential of novel sample application strategies and modifications to
the plate surface to take LDI to another level. Although adaptations of this type have been around almost as long as LDI itself, they
have had a checkered past, and until now have not been widely adopted, either by end‐users or instrument manufacturers. Muthu
and colleagues suggest that this will soon change. A rapidly expanding array of modifications, made possible through advances in
surface engineering and nanotechnology, are now poised to change the way we think about and practice LDI mass spectrometry.
Manikandan Muthu, Dr Manikandan Muthu received his bachelors, masters and Ph.D degrees from the University of Madras, India and pursued
his post-doctoral research at Agricultural Biotechnology research centre, Academia Sinica, Taiwan in 2010 on identifying the molecular sensors
involved in size mediated cell cycle regulation on the unicellular model organism Chlamydomonas. Later in 2011, he joined Professor Wu’s
lab in NSYSU, Taiwan as postdoctoral researcher where he worked on nano platform assisted MALDI Mass spectrometry for the analysis of
various biomolecules from bacterial, plant and animal tissues/cells. He has also worked with Professor Pradeep Thalapil in Indian Institute of
Technology Madras, India on the direct identification of plant based medicinal compounds from plant tissues using DESI MS platform. He is
currently working as Assistant professor in the Department of Environmental Health Science, Konkuk University, Seoul, South Korea. His key
interest lies within the area of developing novel mass spectrometric methods for the early detection of various human diseases.
Sechul Chun, Dr Sechul Chun is a Professor of Department of Environmental Health Science at Konkuk University. He received his BS degree
(1989) in agronomy at Konkuk University, the MS degree (1993) in plant pathology at University of Arkansas and PhD degree (1997) in plant
pathology at Louisiana State University. He has published in: Phytopathology, Scientific Reports, Trends in Analytical Chemistry, Physical Chemistry
Chemical Physics, RSC Advances, Food Chemistry, Microbiological Research, Plant Biology, Journal of Microbiology, Crop Protection, Plant Disease,
Tissue and Organ Culture and Mycobiology. His research interests include nanoscience, drug delivery, biological control of plant pathogen,
cloning of plant pathogen resistant gene and SNP analysis and microbial control of plant pathogen.
Hui-Fen Wu, Dr Hui-Fen Wu is a distinguished professor at National Sun Yat-Sen University, Kaohsiung, Taiwan. She obtained her PhD degree from
University of Texas at Austin, USA (1994) followed by postdoctoral work at the University of California, Berkeley (1994-1996). She joined Tamkang
University, Tamsui, Taiwan, as an Associate Professor (1996-2001) and professor (2001 – 2006). In 2006, she joined the Chemistry Department
of National Sun Yat-Sen University as a senior Professor. Her research work focuses on applications of nanomaterials for biomedicine including
drug delivery for photo-thermal treatment of cancer and neurological diseases. She is actively involved in the development of biosensors and
serves as an editorial board member in various international journals. She is an honorary member in the review committee for the Expensive
Instrument Center, Ministry of Science and Technology & Food and Drug administration of Taiwan. She is the recipient of the 2017 Marque’s life
time achievement, 2016 outstanding academic award and 2014 outstanding paper award of Taiwan Chemical Sensor Society & the Pride of the
Nation Inventor & Academic Award in 2012. She has published over 220 scientific papers, 16 book chapters and has 7 patents.
Mark W. Duncan, Dr Mark W. Duncan recently joined Target Discovery Inc, Palo Alto, CA, as Director, Applications Development & Scientific
Affairs. He is also a Visiting Professor, Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO. He received his B.Sc.
(Hons) in chemistry from UNSW, Sydney, Australia and undertook his Ph.D. in chemistry & neurosciences at the Garvan Institute, also in Sydney.
He was a Fogerty Fellow at the NIH. His research interests include MALDI mass spectrometry, particularly its quantitative and clinical applications.
Judy Gopal, Dr Judy Gopal completed her PhD in the Corrosion Science and Technology Division, Indira Gandhi Centre for Atomic Research,
Kalpakkam, India. Subsequently she worked as a Visiting Scientist, Materials Development Laboratory of the same institute. She has worked as
a National Science Council post-doctoral fellow in the Department of Chemistry, National Sun Yat Sen University Taiwan and at Biotechnology
Department, IIT, Madras, India. Currently she is an Assistant Professor, Konkuk University, Seoul, Korea. Judy is an interdisciplinary scientist who
began her career as a biologist, later obtained her PhD in materials science, and subsequently pursued her post-doctoral studies in analytical
chemistry. Her current work is focused on manipulating nanotechnological interactions in microbiology and cancer biology. She has more than 70
publications covering areas such as biology, materials science, analytical chemistry and medicine. Judy has received several both young achiever
and technical excellence awards.