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I. Reynolds, E. Rush, E. Aizenman (1990)
Reduction of NMDA receptors with dithiothreitol increases [3H]‐MK‐801 binding and NMDA‐induced Ca2+ fluxesBritish Journal of Pharmacology, 101
P. Guyenet, T. Filtz, Steven Donaldson (1987)
Role of excitatory amino acids in rat vagal and sympathetic baroreflexesBrain Research, 407
A. Thomson, D. West, D. Lodge (1985)
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?Nature, 313
E. Aizenman, S. Lipton, R. Loring (1989)
Selective modulation of NMDA responses by reduction and oxidationNeuron, 2
Kleckner Kleckner, Dingledine Dingledine (1988)
Requirement for glycine in activation of N‐methyl‐D‐aspartate receptor‐ion channel complex by L‐glutamate, glycine and polyaminesScience, 241
G. Collingridge, T. Bliss (1987)
NMDA receptors - their role in long-term potentiationTrends in Neurosciences, 10
C. Cotman, A. Foster, T. Lanthorn (1981)
An overview of glutamate as a neurotransmitter.Advances in biochemical psychopharmacology, 27
Scatton Scatton, Frost Frost, George George, Carter Carter, Benavides Benavides (1991b)
Present developments in NMDA receptor antagonists against cerebral ischaemiaCurr Opin Ther Pat, 4
(1991)
Non-competitive NMDA receptor antagonists acting on the polyamine site
Li Chen, L. Huang (1992)
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulationNature, 356
D. Curtis, J. Phillis, J. Watkins (1959)
Chemical Excitation of Spinal NeuronesNature, 183
G. Fagg, A. Foster (1983)
Amino acid neurotransmitters and their pathways in the mammalian central nervous systemNeuroscience, 9
R. Giffard, H. Monyer, C. Christine, D. Choi (1990)
Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical culturesBrain Research, 506
W. Paschen (1992)
Polyamine metabolism in reversible cerebral ischemia.Cerebrovascular and brain metabolism reviews, 4 1
(1991)
1991 b) Present developments in NMDA receptor
V. Teichberg (1991)
Glial glutamate receptors: likely actors in brain signalingThe FASEB Journal, 5
M. Rowley, P. Leeson (1992)
Overview: Excitatory Amino Acid Antagonists, 2
G. Zeevalk, W. Nicklas (1991)
Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition.The Journal of pharmacology and experimental therapeutics, 257 2
(1992)
Possible multiplicity of the NMDA receptor ionophore complex in rat brain
N. Burnashev, Ralf Schoepfer, Hannah Monyer, J. Ruppersberg, W. Günther, P. Seeburg, B. Sakmann (1992)
Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.Science, 257 5075
H. Monyer, R. Sprengel, R. Schoepfer, A. Herb, M. Higuchi, H. Lomelí, N. Burnashev, B. Sakmann, P. Seeburg (1992)
Heteromeric NMDA Receptors: Molecular and Functional Distinction of SubtypesScience, 256
O. Manzoni, L. Prézeau, P. Marin, Solange Deshager, J. Bockaert, L. Fagni (1992)
Nitric oxide-induced blockade of NMDA receptorsNeuron, 8
R. Balázs, N. Hack, Ole J∅rgensen (1988)
Stimulation of the N-methyl-d-aspartate receptor has a trophic effect on differentiating cerebellar granule cellsNeuroscience Letters, 87
(1993)
Release of spermidine from the parietal cortex following middle cerebral artery occlusion in rats
Scatton B ( I 990) Ifen-257
N. Nakanishi, R. Axel, N. Shneider (1992)
Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors.Proceedings of the National Academy of Sciences of the United States of America, 89
W. Hood, R. Compton, J. Monahan (1990)
N‐Methyl‐D‐Aspartate Recognition Site Ligands Modulate Activity at the Coupled Glycine Recognition SiteJournal of Neurochemistry, 54
J. Watkins, P. Korgsgaard-Larsen, T. Honoré (1990)
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.Trends in pharmacological sciences, 11 1
C. Tang, M. Dichter, M. Morad (1990)
Modulation of the N-methyl-D-aspartate channel by extracellular H+.Proceedings of the National Academy of Sciences of the United States of America, 87
D. Choi (1987)
Ionic dependence of glutamate neurotoxicity, 7
Takashi Hayashi (1954)
EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEMThe Keio Journal of Medicine, 3
Lodge Lodge (1989)
Modulation of N‐methyl aspartate receptor‐channel complexesDrugs Today, 25
G. Durand, Paul GREGORt, Xin Zheng, Michael Bennett, George UHLtt, R. Zukin (1992)
Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C.Proceedings of the National Academy of Sciences of the United States of America, 89
R. Henneberry (1989)
The role of neuronal energy in the neurotoxicity of excitatory amino acidsNeurobiology of Aging, 10
A. Foutz, J. Champagnat, M. Denavit‐Saubié (1988)
N-Methyl-d-aspartate (NMDA) receptors control respiratory off-switch in catNeuroscience Letters, 87
R. Ransom, N. Deschenes (1990)
Polyamines regulate glycine interaction with the N‐methyl‐D‐aspartate receptorSynapse, 5
Foutz Foutz, Champagnat Champagnat, Denavit‐Saubié Denavit‐Saubié (1988)
N‐methyl‐D‐aspartate (NMDA) receptors control respiratory off‐switch in catNeurosci Lett, 87
D. Monaghan, R. Bridges, C. Cotman (1989)
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.Annual review of pharmacology and toxicology, 29
S. Nakanishi (1992)
Molecular diversity of glutamate receptors and implications for brain function.Science, 258 5082
P. Ascher, L. Nowak (1987)
Electrophysiological studies of NMDA receptorsTrends in Neurosciences, 10
H. Mori, Hisashi Masaki, T. Yamakura, M. Mishina (1992)
Identification by mutagenesis of a Mg2+ -block site of the NMDA receptor channelNature, 358
Y. Ben-Ari, L. Aniksztejn, P. Bregestovski (1992)
Protein kinase C modulation of NMDA currents: an important link for LTP inductionTrends in Neurosciences, 15
J. Willetts, R. Balster, J. Leander (1990)
The behavioral pharmacology of NMDA receptor antagonists.Trends in pharmacological sciences, 11 10
A. Dumuis, M. Sebben, L. Haynes, J. Pin, J. Bockaert (1988)
NMDA receptors activate the arachidonic acid cascade system in striatal neuronsNature, 336
F. Fonnum (1984)
Glutamate: A Neurotransmitter in Mammalian BrainJournal of Neurochemistry, 42
Rowley Rowley, Leeson Leeson (1992)
Excitatory amino acid antagonistsCurr Opin Ther Pat, 2
C. Cotman, D. Monaghan, O. Ottersen, J. Storm-Mathisen (1987)
Anatomical organization of excitatory amino acid receptors and their pathwaysTrends in Neurosciences, 10
C. Carter, M. Savasta, D. Fage, B. Scatton (1986)
2-Oxo-[14C]glutarate is taken up by glutamatergic nerve terminals in the rat striatumNeuroscience Letters, 72
Seth Karp, M. Masu, T. Eki, Kazuo Ozawa, S. Nakanishi (1993)
Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor.The Journal of biological chemistry, 268 5
neurotransmitters: from basic science to
J. Cheung, J. Bonventre, C. Malis, A. Leaf (1986)
Calcium and ischemic injury.The New England journal of medicine, 314 26
D. Rhoads, L. Osburn, N. Peterson, E. Raghupathy (1983)
Release of Neurotransmitter Amino Acids from Synaptosomes: Enhancement of Calcium‐Independent Efflux by Oleic and Arachidonic AcidsJournal of Neurochemistry, 41
(1989)
R 61 e des acides aminks exci - tateurs dans la pathologie des dommages isch 6 miques cCr 6 braux
J. Johnson, P. Ascher (1987)
Glycine potentiates the NMDA response in cultured mouse brain neuronsNature, 325
J. Greenamyre, James Olson, J. Penney, Anne Young (1985)
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.The Journal of pharmacology and experimental therapeutics, 233 1
A. Kleinschmidt, M. Bear, W. Singer (1987)
Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex.Science, 238 4825
S. Rothman, J. Olney (1986)
Glutamate and the pathophysiology of hypoxic–ischemic brain damageAnnals of Neurology, 19
K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, S. Nakanishi (1991)
Molecular cloning and characterization of the rat NMDA receptorNature, 354
B. Scatton, C. Carter, J. Benavides, C. Giroux (1991)
N-Methyl-D-Aspartate Receptor Antagonists: A Novel Therapeutic Perspective for the Treatment of Ischemic Brain InjuryCerebrovascular Diseases, 1
(1992)
The multiple excitatory amino acid receptor subtypes and their putative interactions
R. Ransom, N. Stec (1988)
Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and PolyaminesJournal of Neurochemistry, 51
A. Porcella, D. Fage, C. Voltz, F. Bourdiol, J. Benavides, B. Scatton, C. Carter (1992)
Implication of the polyamines in the neurotoxic effects of N-methyl-D-aspartate.Neurological research, 14 2 Suppl
M. Krebs, F. Trovero, M. Desban, C. Gauchy, J. Glowinski, M. Kemel (1991)
Distinct presynaptic regulation of dopamine release through NMDA receptors in striosome- and matrix-enriched areas of the rat striatum, 11
Robinson Robinson, Coyle Coyle (1987)
Glutamate and related acidic excitatory neurotransmitters: from basic science to clinical applicationFASEB J, 1
S. Traynelis, S. Cull-Candy (1990)
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neuronsNature, 345
A. Young, G. Fagg (1990)
Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches.Trends in pharmacological sciences, 11 3
B. Miller, M. Sarantis, S. Traynelis, D. Attwell (1992)
Potentiation of NMDA receptor currents by arachidonic acidNature, 355
A. MacDermott, N. Dale (1987)
Receptors, ion channels and synaptic potentials underlying the integrative actions of excitatory amino acidsTrends in Neurosciences, 10
Present developments in NMDA receptor 8 5 5 285 5 6 59 - 88 15 - 3 1 41 , 531 - 537 antagonists against cerebral ischaemia
P. Chan, R. Kerlan, R. Fishman (1983)
Reductions of Γ‐Aminobutyric Acid and Glutamate Uptake and (Na++ K+)‐ATPase Activity in Brain Slices and Synaptosomes by Arachidonic AcidJournal of Neurochemistry, 40
X. Xie, T. Smart (1991)
A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmissionNature, 349
N. Kleckner, R. Dingledine (1988)
Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes.Science, 241 4867
Carter (1990)
Ifenprodil and SL 82.0715 as cerebral anti-ischaemic agents. III. Evidence for antagonist effects at the polyamine modulatory site within the NMDA receptor complexJ Pharmacol Exp Ther, 253
D. Bredt, S. Snyder (1992)
Nitric oxide, a novel neuronal messengerNeuron, 8
D. Monaghan, D. Yao, C. Cotman (1985)
l-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysisBrain Research, 340
M. Globus, M. Ginsberg, R. Busto (1991)
Excitotoxic index — a biochemical marker of selective vulnerabilityNeuroscience Letters, 127
B. Sommer, P. Seeburg (1992)
Glutamate receptor channels: novel properties and new clones.Trends in pharmacological sciences, 13 7
S. Lei, Z. Pan, S. Aggarwal, Huei‐Sheng Chen, Jonathan Hartman, N. Sucher, S. Lipton (1992)
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complexNeuron, 8
T. Kutsuwada, N. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, Hisashi Masaki, T. Kumanishi, M. Arakawa, M. Mishina (1992)
Molecular diversity of the NMDA receptor channelNature, 358
C. Carter, K. Lloyd, B. Ẑivković, B. Scatton (1990)
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.The Journal of pharmacology and experimental therapeutics, 253 2
M. Mayer, L. Vyklický, E. Sernagor (1989)
A physiologist's view of the N‐methyl‐D‐Aspartate receptor: An allosteric ion channel with multiple regulatory sitesDrug Development Research, 17
Hidemitsu Sugihara, K. Moriyoshi, Takahiro Ishii, Masayuki Masu, Shigetada Nakanishi (1992)
Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing.Biochemical and biophysical research communications, 185 3
Summary— The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing. These characteristics allow it to be involved in the maintainance of rhythmic neuronal activity and in the modulation of synaptic efficacy and plasticity. Overstimulation of the NMDA receptor appears to play a pivotal role in the physiopathology of ischemic brain injury. The NMDA receptor contains an integral cationic channel which is highly permeable to Ca2+ as well as to Na+ and K+. This receptor has several domains in addition to the NMDA recognition site: i) a divalent cation binding site within the channel pore, at which Mg2+ ions bind, ii) a binding site recognized by dissociative anesthetics and MK‐801 within the channel; and iii) modulatory sites sensitive to glycine, Zn2+ and polyamines. The NMDA receptor is strictly controlled by Mg2+ ions in a voltage‐dependent manner. Moreover, it is modulated by protons, by changes in the redox state and by endogenous physiological substances, eg NO and arachidonic acid. Selective antagonists now exist for the NMDA recognition site and glycine and polyamine modulatory sites. Molecular cloning of the NMDA receptor has identified a subunit termed NMDA‐R1 and four additional subunits (NMDA‐R2A through NMDA‐R2D). Functionally distinct NMDA receptor subtypes are formed by heteromeric assembly of NMDA‐R1 with NMDA‐R2 subunits. NMDA receptor subunits contain consensus phosphorylation sites for protein kinases at the cytoplasmic domain. The high Ca2+ permeability and sensitivity to channel block by Mg2+ are imparted by asparagine residues in a putative channel‐forming segment of the protein transmembrane 2. The knowledge of the molecular structure of the NMDA receptor will help to understand the molecular mechanisms responsible for its regulatory features and the molecular bases of neurotoxicity.
Fundamental & Clinical Pharmacology – Wiley
Published: Nov 1, 1993
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