The Molecular Basis of Kindling

The Molecular Basis of Kindling Kindling is an experimental model of epilepsy that involves activity‐dependent changes in neuronal structure and function. During kindling, pathological changes may occur at several organizational levels of the nervous system, from alterations in gene‐expression in individual neurons to the loss of specific neuronal populations and rearrangement of synaptic connectivity resulting from sustained stimulation of major excitatory pathways. This review summarizes recent developments in alterations at single neuronal and molecular levels that may be responsible for kindling epileptogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Pathology Wiley

The Molecular Basis of Kindling

Brain Pathology, Volume 3 (4) – Oct 1, 1993

Loading next page...
 
/lp/wiley/the-molecular-basis-of-kindling-y9eVXifMra
Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1015-6305
eISSN
1750-3639
D.O.I.
10.1111/j.1750-3639.1993.tb00767.x
Publisher site
See Article on Publisher Site

Abstract

Kindling is an experimental model of epilepsy that involves activity‐dependent changes in neuronal structure and function. During kindling, pathological changes may occur at several organizational levels of the nervous system, from alterations in gene‐expression in individual neurons to the loss of specific neuronal populations and rearrangement of synaptic connectivity resulting from sustained stimulation of major excitatory pathways. This review summarizes recent developments in alterations at single neuronal and molecular levels that may be responsible for kindling epileptogenesis.

Journal

Brain PathologyWiley

Published: Oct 1, 1993

References

  • Endogenous intracellular calcium buffering and the activation/inactivation of HVA calcium currents in rat dentate gyrus granule cells
    Köhr, Köhr; Mody, Mody
  • Activation of N‐methyl‐D‐aspartate receptors parallels changes in cellular and synaptic properties of dentate gyrus granule cells after kindling
    Mody, Mody; Stanton, Stanton; Heinemann, Heinemann
  • Mossy fiber synaptic reorganization in the epileptic human temporal lobe
    Sutula, Sutula; Cascino, Cascino; Cavazos, Cavazos; Parada, Parada; Ramirez, Ramirez
  • Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region
    Represa, Represa; Ben‐Ari, Ben‐Ari
  • Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites
    Represa, Represa; Jorquera, Jorquera; Salle, Salle; Ben‐Ari, Ben‐Ari
  • Calcium currents in acutely isolated human neocortical neurons
    Sayer, Sayer; Brown, Brown; Schwindt, Schwindt; Crill, Crill
  • Epileptogenesis as a plastic phenomenon of the brain, a short review
    Silva, Silva; Kamphuis, Kamphuis; Wadman, Wadman
  • Neurophysiology of epilepsy
    Prince, Prince
  • Seizure‐triggering mechanisms in the kindling model of epilepsy: Collapse of GABA‐mediated inhibition and activation of NMDA receptors
    Morimoto, Morimoto
  • Horizontal spread of synchronized activity in neocortex, and its control by GABA‐mediated inhibition
    Chagnac‐Amitai, Chagnac‐Amitai; Connors, Connors
  • Low extracellular magnesium induces epileptiform activity and spreading depression in rat hippocampal slices
    Mody, Mody; Lambert, Lambert; Heinemann, Heinemann
  • Alterations of inhibitory processes in the dentate gyrus following kindling‐induced epilepsy
    Oliver, Oliver; Miller, Miller
  • Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: A patch‐clamp study
    Edwards, Edwards; Konnerth, Konnerth; Sakmann, Sakmann
  • Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells
    Staley, Staley; Mody, Mody
  • Differential activation of GABAA and GABAB receptors by spontaneously released transmitter
    Otis, Otis; Mody, Mody
  • The multifunctional Ca 2+ /calmodulin‐dependent protein kinase
    Schulman, Schulman

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off