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The Mitochondrial Complex I: Progress in Understanding of Catalytic Properties

The Mitochondrial Complex I: Progress in Understanding of Catalytic Properties Although the mitochondrial Complex I has been extensively studied for over 4 decades, its catalytic properties in mitochondria are poorly understood. This review summarizes the data on standard and nonstandard kinetic parameters of the enzyme. The slow interconversion between active and deactivated forms of the mammalian Complex I (A/D transition) is described. We discuss the potential relevance of this transition for the regulation of NADH oxidation by the respiratory chain under physiological and pathophysiological conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

The Mitochondrial Complex I: Progress in Understanding of Catalytic Properties

IUBMB Life , Volume 52 (3‐5) – Sep 1, 2001

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References (37)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2001 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216540152845920
pmid
11798024
Publisher site
See Article on Publisher Site

Abstract

Although the mitochondrial Complex I has been extensively studied for over 4 decades, its catalytic properties in mitochondria are poorly understood. This review summarizes the data on standard and nonstandard kinetic parameters of the enzyme. The slow interconversion between active and deactivated forms of the mammalian Complex I (A/D transition) is described. We discuss the potential relevance of this transition for the regulation of NADH oxidation by the respiratory chain under physiological and pathophysiological conditions.

Journal

IUBMB LifeWiley

Published: Sep 1, 2001

Keywords: Nadh Ubiquinone Oxidoreductase; Electron Transfer; Respiratory Chain

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