The long‐QT syndrome and exercise practice: The never‐ending debate

The long‐QT syndrome and exercise practice: The never‐ending debate Today, understanding the true risk of adverse events in long‐QT syndrome (LQTS) populations may be extremely complex and potentially dependent on many factors such as the affected gene, mutation location, degree of QTc prolongation, age, sex, and other yet unknown factors. In this context, risk stratification by genotype in LQTS patients has been extremely difficult, also during exercise practice, especially due to the lack of studies that would lead to a better understanding of the natural history of each mutation and its impact upon athletes. The creation of individualized guidelines for sport participation is a goal yet to be achieved not only due to the complexity of genotype effect on the phenotype in this patient population, but also due to penetrance in genotype‐positive patients. This article summarizes current knowledge and raises questions concerning the difficult relationship between exercise practice and LQTS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cardiovascular Electrophysiology Wiley

The long‐QT syndrome and exercise practice: The never‐ending debate

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Journal compilation © 2018 Wiley Periodicals, Inc.
ISSN
1045-3873
eISSN
1540-8167
D.O.I.
10.1111/jce.13410
Publisher site
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Abstract

Today, understanding the true risk of adverse events in long‐QT syndrome (LQTS) populations may be extremely complex and potentially dependent on many factors such as the affected gene, mutation location, degree of QTc prolongation, age, sex, and other yet unknown factors. In this context, risk stratification by genotype in LQTS patients has been extremely difficult, also during exercise practice, especially due to the lack of studies that would lead to a better understanding of the natural history of each mutation and its impact upon athletes. The creation of individualized guidelines for sport participation is a goal yet to be achieved not only due to the complexity of genotype effect on the phenotype in this patient population, but also due to penetrance in genotype‐positive patients. This article summarizes current knowledge and raises questions concerning the difficult relationship between exercise practice and LQTS.

Journal

Journal of Cardiovascular Electrophysiology – Wiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

  • Congenital deaf‐mutism, functional heart disease with prolongation of the Q‐T interval and sudden death
    Jervell, A; Lange‐Nielsen, F
  • Rare cardiac arrhythmias of the pediatric age. II. Syncopal attacks due to paroxysmal ventricular fibrillation. (Presentation of 1st case in Italian pediatric literature)
    Romano, C; Gemme, G; Pongiglione, R
  • A new familial cardiac syndrome in children
    Ward, OC
  • Cardiac channelopathies: It's in the genes
    Ackerman, MJ
  • International Long QT Syndrome Registry. Risk factors for recurrent syncope and subsequent fatal or near‐fatal events in children and adolescents with long QT syndrome
    Liu, JF; Jons, C; Moss, AJ
  • Prevalence and significance of an isolated long QT interval in elite athletes
    Basavarajaiah, S; Wilson, M; Whyte, G; Shah, A; Behr, E; Sharma, S
  • Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras‐1 gene
    Keating, M; Atkinson, D; Dunn, C; Timothy, K; Vincent, GM; Leppert, M
  • Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes
    Priori, SG; Wilde, AA; Horie, M
  • Low penetrance in the long‐QT syndrome: Clinical impact
    Priori, SG; Napolitano, C; Schwartz, PJ
  • QTc behavior during exercise and genetic testing for the long‐QT syndrome
    Schwartz, PJ; Crotti, L
  • Diagnostic criteria for the long QT syndrome
    Schwartz, PJ; Moss, AJ; Vincent, GM; Crampton, RS
  • The congenital long QT syndromes from genotype to phenotype: Clinical implications
    Schwartz, PJ
  • Derivation and validation of a simple exercise‐based algorithm for prediction of genetic testing in relatives of LQTS probands
    Sy, RW; der Werf, C; Chattha, IS
  • Long QT‐syndrome. From genetics to management
    Schwartz, PJ; Crotti, L; Insolia, R
  • Risk stratification in the long‐QT syndrome
    Priori, SG; Schwartz, PJ; Napolitano, C
  • Accurate electrocardiographic assessment of the QT interval: Teach the tangent
    Postema, PG; Jong, JS; der Bilt, IA; Wilde, AA
  • QT interval in right and left bundle‐branch block
    Talbot, S
  • Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy
    Jouven, X; Hagege, A; Charron, P
  • Long QT syndrome and short QT syndrome: How to make correct diagnosis and what about eligibility for sports activity
    Napolitano, C; Bloise, R; Priori, SG
  • Electrocardiographic manifestations: Electrolyte abnormalities
    Diercks, DB; Shumaik, GM; Harrigan, RA; Brady, WJ; Chan, TC
  • Prolonged QT interval corrected for heart rate during diabetic ketoacidosis in children
    Kuppermann, N; Park, J; Glatter, K; Marcin, JP; Glaser, NS
  • A meta‐analysis of heart rate and QT interval alteration in anorexia nervosa
    Lesinskiene, S; Barkus, A; Ranceva, N; Dembinskas, A
  • Inaccurate electrocardiographic interpretation of long QT: The majority of physicians cannot recognize a long QT when they see one
    Viskin, S; Rosovski, U; Sands, AJ
  • Congenital long QT syndrome: Considerations for primary care physicians
    Levine, E; Rosero, SZ; Budzikowski, AS; Moss, AJ; Zareba, W; Daubert, JP
  • Athlete's heart
    Fagard, R
  • Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects
    Swan, H; Viitasalo, M; Piippo, K; Laitinen, P; Kontula, K; Toivonen, L
  • Exercise stress test amplifies genotype‐phenotype correlation in the LQT1 and LQT2 forms of the long‐QT syndrome
    Takenaka, K; Ai, T; Shimizu, W
  • Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION long QT syndrome genetic test
    Kapplinger, JD; Tester, DJ; Salisbury, BA
  • Genotype‐phenotype correlation in the long‐QT syndrome: Gene‐specific triggers for life‐threatening arrhythmias
    Schwartz, PJ; Priori, SG; Spazzolini, C
  • Genotype‐specific onset of arrhythmias in congenital long‐QT syndrome: Possible therapy implications
    Tan, HL; Bardai, A; Shimizu, W
  • Spontaneous onset of torsade de pointes in long‐QT syndrome and the role of sympathovagal imbalance
    Fujiki, A; Nishida, K; Mizumaki, K; Nagasawa, H; Shimono, M; Inoue, H
  • Cellular mechanisms underlying the long QT syndrome
    Antzelevitch, C; Shimizu, W
  • Molecular and cellular mechanisms of cardiac arrhythmias
    Keating, MT; Sanguinetti, MC
  • Understanding the microscopic mechanisms for LQT1 needs a global view of the I(Ks) channel
    Tseng, GN; Xu, Y
  • Cellular basis for the ECG features of the LQT1 form of the long QT syndrome: Effects of b‐adrenergic agonists and antagonists and sodium channels blockers on transmural dispersion of repolarization and torsade de pointes
    Shimizu, W; Antzelevitch, C
  • Spectrum and frequency of cardiac channel defects in swimming‐triggered arrhythmia syndromes
    Choi, G; Kopplin, LJ; Tester, DJ; Will, ML; Haglund, CM; Ackerman, MJ
  • Differential response to Na+ channel blockade, beta‐adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long‐QT syndrome
    Priori, SG; Napolitano, C; Cantù, F; Brown, AM; Schwartz, PJ
  • Genotype‐ and mutation site‐specific QT adaptation during exercise, recovery, and postural changes in children with long‐QT syndrome
    Aziz, PF; Wieand, TS; Ganley, J
  • Auditory stimuli as a trigger for arrhythmic events differentiate HERG‐related (LQTS2) patients from KVLQT1‐related patients (LQTS1)
    Wilde, AA; Jongbloed, RJ; Doevendans, PA
  • The mechanism of pause‐induced torsade de pointes in long QT syndrome
    Liu, J; Laurita, KR
  • Early after‐depolarizations induced by isoproterenol in patients with congenital long QT syndrome
    Shimizu, W; Ohe, T; Kurita, T
  • Differential effects of beta‐adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome
    Shimizu, W; Antzelevitch, C
  • Pause induced early after‐depolarizations in the long QT syndrome: A simulation study
    Viswanathan, PC; Rudy, Y
  • Multiple mechanisms in the long‐QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS
    Roden, DM; Lazzara, R; Rosen, M; Schwartz, PJ; Towbin, J; Vincent, GM
  • Genetic and molecular basis of cardiac arrhythmias; impact on clinical management
    Priori, SG; Barhanin, J; Hauer, RN
  • Influence of genotype on the clinical course of the long‐QT syndrome. International Long‐QT Syndrome Registry Research Group
    Zareba, W; Moss, AJ; Schwartz, PJ
  • Task Force 8: Classification of sports
    Mitchell, JH; Haskell, W; Snell, P; Camp, SP
  • Recommendations for competitive sports participation in athletes with cardiovascular disease: A consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology
    Pelliccia, A; Fagard, R; Bjørnstad, HH
  • Recommendations for participation in leisure‐time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part II: Ventricular arrhythmias, channelopathies and implantable defibrillators
    Heidbüchel, H; Corrado, D; Biffi, A
  • Bethesda Conference #36 and the European Society of Cardiology Consensus Recommendations revisited a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities
    Pelliccia, A; Zipes, DP; Maron, BJ
  • Return to play? Athletes with congenital long QT syndrome
    Johnson, JN; Ackerman, MJ
  • Sports participation in genotype positive children with long QT syndrome
    Aziz, PF; Sweeten, T; Vogel, RL
  • Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 10: The cardiac channelopathies: A scientific statement from the American Heart Association and American College of Cardiology
    Ackerman, MJ; Zipes, DP; Kovacs, RJ; Maron, BJ
  • Introduction: Eligibility recommendations for competitive athletes with cardiovascular abnormalities‐general considerations
    Maron, BJ; Zipes, DP
  • Safety of sports for athletes with implantable cardioverter‐defibrillators: Results of a prospective, multinational registry
    Lampert, R; Olshansky, B; Heidbuchel, H
  • Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: Task Force 9: Arrhythmias and conduction defects: A scientific statement from the American Heart Association and American College of Cardiology
    Zipes, DP; Link, MS; Ackerman, MJ; Kovacs, RJ; Myerburg, RJ
  • Long‐term follow‐up of patients with long‐QT syndrome treated with beta‐blockers and continuous pacing
    Dorostkar, PC; Eldar, M; Belhassen, B; Scheinman, MM
  • Effectiveness and limitations of beta‐blocker therapy in congenital long‐QT syndrome
    Moss, AJ; Zareba, W; Hall, WJ
  • Clinical aspects of type 3 long‐QT syndrome: An international multicenter study
    Wilde, AA; Moss, AJ; Kaufman, ES
  • Gating properties of SCN5A mutations and the response to mexiletine in long‐QT syndrome type 3 patients
    Ruan, Y; Liu, N; Bloise, R; Napolitano, C; Priori, SG
  • Gene‐specific therapy with mexiletine reduces arrhythmic events in patients with long QT syndrome type 3
    Mazzanti, A; Maragna, R; Faragli, A
  • Not all beta‐blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol
    Chockalingam, P; Crotti, L; Girardengo, G
  • Left cardiac sympathetic denervation in the management of high‐risk patients affected by the long‐QT syndrome
    Schwartz, PJ; Priori, SG; Cerrone, M

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