The Influence of Redox‐Active Transition Metal Containing Micro‐ and Nanoparticles on the Properties of Representative Bioinorganic Reaction Systems

The Influence of Redox‐Active Transition Metal Containing Micro‐ and Nanoparticles on the... The use of nanomaterials in biological applications requires a better understanding of the effect of nanoparticles on the activity of proteins and related molecules. We have examined the influence of environmental particulate matter (PM) on the interaction of myoglobin and microperoxidase‐11 as model systems with the small molecules O2 and NO, respectively. The influence of PM on the reaction of dioxygen with deoxymyoglobin to form oxymyoglobin, and subsequently metmyoglobin, was studied for its essential role in living organisms. Samples of urban PM (SRM 1648a) were used as standard reference material. Also the influence of Fe2O3 nanoparticles on the stability of the investigated protein was studied. The obtained results show that binding and release of dioxygen by deoxymyoglobin may be affected by the presence of PM especially over longer periods of time. Similar studies were performed on the nitrosylation of microperoxidase‐11 as a model for the catalytic center of enzymes, for which the influence of the standard reference material, its water‐soluble extract, as well as metal oxide nanoparticles (Fe2O3 and ZnO), were studied. The reported results show that the presence of PM had no influence on the kinetics of the nitrosylation of the model microperoxidase under the selected experimental conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Inorganic Chemistry Wiley

The Influence of Redox‐Active Transition Metal Containing Micro‐ and Nanoparticles on the Properties of Representative Bioinorganic Reaction Systems

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
1434-1948
eISSN
1099-0682
D.O.I.
10.1002/ejic.201701421
Publisher site
See Article on Publisher Site

Abstract

The use of nanomaterials in biological applications requires a better understanding of the effect of nanoparticles on the activity of proteins and related molecules. We have examined the influence of environmental particulate matter (PM) on the interaction of myoglobin and microperoxidase‐11 as model systems with the small molecules O2 and NO, respectively. The influence of PM on the reaction of dioxygen with deoxymyoglobin to form oxymyoglobin, and subsequently metmyoglobin, was studied for its essential role in living organisms. Samples of urban PM (SRM 1648a) were used as standard reference material. Also the influence of Fe2O3 nanoparticles on the stability of the investigated protein was studied. The obtained results show that binding and release of dioxygen by deoxymyoglobin may be affected by the presence of PM especially over longer periods of time. Similar studies were performed on the nitrosylation of microperoxidase‐11 as a model for the catalytic center of enzymes, for which the influence of the standard reference material, its water‐soluble extract, as well as metal oxide nanoparticles (Fe2O3 and ZnO), were studied. The reported results show that the presence of PM had no influence on the kinetics of the nitrosylation of the model microperoxidase under the selected experimental conditions.

Journal

European Journal of Inorganic ChemistryWiley

Published: Jan 14, 2018

Keywords: ; ; ; ;

References

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