The in Vivo Survival of Red Blood Cells Stored in Modified CPD with Adenine: Report of a Multi‐Institutional Cooperative Effort

The in Vivo Survival of Red Blood Cells Stored in Modified CPD with Adenine: Report of a... In order to provide data in support of licensure applications for citrate‐phosphate‐dextrose (CPD) supplemented with adenine, a multi‐institutional cooperative effort was organized to determine survivability of red blood cells subjected to prolonged liquid storage. Two manufacturers supplied plastic multiple bag blood storage containers prefilled with modified CPD (glucose 25% greater than the normal concentration) supplemented with adenine (17.0 to 17.3 mg per 63 ml of anticoagulant; 0.25 millimolar approximate final concentration when diluted with 450 ml of whole blood). Red blood cells from 32 units stored as whole blood for 35 days showed a mean survival of 80.53 + 6.44 per cent (1 SD). Both red blood cell and supernatant plasma biochemical characteristics were comparable to those reported for whole blood stored for 21 days in either acid‐citrate‐dextrose (ACD) or CPD. Red blood cells from 19 units stored as concentrates for 35 days (Hct 75.03 + 3.74%) had a mean survival of 71.38 + 10.3 per cent with considerable interdonor variation in survival and interlaboratory variation in some biochemical characteristics. Red blood cells from eight units stored as concentrates (Hct 75.38 + 4.30%) for 28 days showed a mean survival of 83.97 + 6.10 per cent and biochemical characteristics comparable to those reported for red blood‐cell concentrates stored in CPD or ACD for 21 days. Modified CPD with adenine as formulated offers an improved anticoagulant for blood banking by extending the permissible red blood cell storage period. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Wiley

The in Vivo Survival of Red Blood Cells Stored in Modified CPD with Adenine: Report of a Multi‐Institutional Cooperative Effort

Loading next page...
 
/lp/wiley/the-in-vivo-survival-of-red-blood-cells-stored-in-modified-cpd-with-zVM380Qvex
Publisher site
See Article on Publisher Site

Abstract

In order to provide data in support of licensure applications for citrate‐phosphate‐dextrose (CPD) supplemented with adenine, a multi‐institutional cooperative effort was organized to determine survivability of red blood cells subjected to prolonged liquid storage. Two manufacturers supplied plastic multiple bag blood storage containers prefilled with modified CPD (glucose 25% greater than the normal concentration) supplemented with adenine (17.0 to 17.3 mg per 63 ml of anticoagulant; 0.25 millimolar approximate final concentration when diluted with 450 ml of whole blood). Red blood cells from 32 units stored as whole blood for 35 days showed a mean survival of 80.53 + 6.44 per cent (1 SD). Both red blood cell and supernatant plasma biochemical characteristics were comparable to those reported for whole blood stored for 21 days in either acid‐citrate‐dextrose (ACD) or CPD. Red blood cells from 19 units stored as concentrates for 35 days (Hct 75.03 + 3.74%) had a mean survival of 71.38 + 10.3 per cent with considerable interdonor variation in survival and interlaboratory variation in some biochemical characteristics. Red blood cells from eight units stored as concentrates (Hct 75.38 + 4.30%) for 28 days showed a mean survival of 83.97 + 6.10 per cent and biochemical characteristics comparable to those reported for red blood‐cell concentrates stored in CPD or ACD for 21 days. Modified CPD with adenine as formulated offers an improved anticoagulant for blood banking by extending the permissible red blood cell storage period.

Journal

TransfusionWiley

Published: Jul 8, 1977

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off