The impact of MUC5B gene on dental caries

The impact of MUC5B gene on dental caries INTRODUCTIONDental caries is a chronic, complex, and multifactorial disease (Fejerskov, ) that is highly prevalent in both industrialized and developing countries (Petersen, ). According to the latest epidemiological survey, the DMFT index (number of decayed, missing, and filled teeth) has declined, nonetheless, dental caries continues to be one of the major diseases in oral health (Petersen, ). It is widely accepted that the occurrence of the disease depends on environmental (distal) and host (proximal) factors. One of the proximal risk factors for developing dental caries is saliva composition (Fejerskov & Manji, ).Saliva contains salivary mucins (MUC7, MUC1, and MUC5B) that cover and protect the mucosa and tooth surfaces. They also maintain the viscoelastic, hydrophobic, and lubricative properties of saliva. There are two genetically distinct types of mucins: high molecular weight (MG1) and low molecular weight (MG2). The MG1 mucin is encoded by the MUC5B gene. MG1 mucin consists of 15% protein and 78% carbohydrate, and it appears to exist as oligomeric and monomeric units. MG1 mucin is synthesized in the mucous cells of the submandibular, sublingual, and other minor glands (Pol et al. ). The MUC5B gene is located in chromosome 11 (11p15.5), and the protein functions to form a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Diseases Wiley

The impact of MUC5B gene on dental caries

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley &Sons Ltd
ISSN
1354-523X
eISSN
1601-0825
D.O.I.
10.1111/odi.12784
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONDental caries is a chronic, complex, and multifactorial disease (Fejerskov, ) that is highly prevalent in both industrialized and developing countries (Petersen, ). According to the latest epidemiological survey, the DMFT index (number of decayed, missing, and filled teeth) has declined, nonetheless, dental caries continues to be one of the major diseases in oral health (Petersen, ). It is widely accepted that the occurrence of the disease depends on environmental (distal) and host (proximal) factors. One of the proximal risk factors for developing dental caries is saliva composition (Fejerskov & Manji, ).Saliva contains salivary mucins (MUC7, MUC1, and MUC5B) that cover and protect the mucosa and tooth surfaces. They also maintain the viscoelastic, hydrophobic, and lubricative properties of saliva. There are two genetically distinct types of mucins: high molecular weight (MG1) and low molecular weight (MG2). The MG1 mucin is encoded by the MUC5B gene. MG1 mucin consists of 15% protein and 78% carbohydrate, and it appears to exist as oligomeric and monomeric units. MG1 mucin is synthesized in the mucous cells of the submandibular, sublingual, and other minor glands (Pol et al. ). The MUC5B gene is located in chromosome 11 (11p15.5), and the protein functions to form a

Journal

Oral DiseasesWiley

Published: Jan 1, 2018

Keywords: ; ;

References

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