The genetics of peptidase C in man BY SUSAN POVEY, G. CORNEY, W. H. P. LEWIS, ELIZABETH B. ROBSON, JENNIFER M. PARRINGTON AND HARRY HARRIS MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London Several distinct peptidases, which may be differentiated by their electrophoretic characteristics, their pattern of substrate specificity and their molecular size, have been demonstrated in human cells (Lewis & Harris, 1967, 1969a; Rapley, Lewis & Harris, 1971). They are referred t o as peptidases A, B, C, D, E, F and S and are thought to be determined by separate gene loci. Genetically determined variants of Pep A, B and D in European, Indian and Negro populations and in Australian aborigines have been described (Lewis & Harris, 1967; Lewis, Corney & Harris, 1968; Lewis & Harris, 1969b; Blake et al. 1970). Genetic variation in Peptidase C (Pep C) has until now only been reported in a group of Babinga pygmies (Santachiara Benerecetti, 1970). She found 5 examples out of 261 random blood samples in which an additional band of Pep C activity appeared, with a lower mobility than the usual Pep C band, and two examples in which the normal band was entirely
Annals of Human Genetics – Wiley
Published: Apr 1, 1972
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