The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system

The formation of a structure with the features of synovial lining by subcutaneous injection of... We have attempted to verify the suggestion that synovial membrane is the result of mechanical disruption of connective tissue, and may occur at any site. Mechanical disruption of the subcutaneous connective tissue was achieved in rats and mice by the repeated injection of air. The resulting cavities developed a lining structure with many of the features of synovial membrane as judged by electron microscopy, and light microscopy using haematoxylin and eosin and van Gieson stains, esterase activity and immunofluorescent staining for Ia antigen. A structure closely resembling synovium is formed as early as 6 days, providing a convenient method for studying large quantities of facsimile synovial tissue under a wide variety of easily administered stimuli. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Pathology Wiley

The formation of a structure with the features of synovial lining by subcutaneous injection of air: An in vivo tissue culture system

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Publisher
Wiley
Copyright
Copyright © 1981 The Pathological Society of Great Britain and Ireland
ISSN
0022-3417
eISSN
1096-9896
DOI
10.1002/path.1711340205
Publisher site
See Article on Publisher Site

Abstract

We have attempted to verify the suggestion that synovial membrane is the result of mechanical disruption of connective tissue, and may occur at any site. Mechanical disruption of the subcutaneous connective tissue was achieved in rats and mice by the repeated injection of air. The resulting cavities developed a lining structure with many of the features of synovial membrane as judged by electron microscopy, and light microscopy using haematoxylin and eosin and van Gieson stains, esterase activity and immunofluorescent staining for Ia antigen. A structure closely resembling synovium is formed as early as 6 days, providing a convenient method for studying large quantities of facsimile synovial tissue under a wide variety of easily administered stimuli.

Journal

The Journal of PathologyWiley

Published: Jun 1, 1981

References

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