The Fetus as an Allograft: a Longitudinal Study of Normal Human Pregnancies Studied with Mixed Lymphocyte Cultures between Mother‐Father and Mother‐Child

The Fetus as an Allograft: a Longitudinal Study of Normal Human Pregnancies Studied with Mixed... A longitudinal investigation of the mixed lymphocyte culture (MLC) response during pregnancy between mother and father, between mother and child, and between the mother and an indifferent lymphocyte pool has been carried out, using starting values before pregnancy and a cryobiological freezing system that allows in vitro playback of the immunological course of pregnancy. Lymphocyte and serum samples from twenty‐two pregnant women taken before and during pregnancy, at delivery, and after delivery were used. The study shows that the mother reacts during the course of pregnancy with an increasing MLC response to the father, which is replaced at delivery by a decrease in response and a subsequent increase after delivery. It is also shown that the mother reacts to the child in a similar manner at about half the level of reaction to the father. The mother also reacts similarly to a pool of indifferent lymphocytes. The MLC reactions mentioned are affected by both non‐pregnant and pregnant serum, leading to a moderation of the MLC reaction in relation to that carried out in neutral AB serum. In addition, there seems to be cooperation between cellular and humoral factors, since the MLC reaction to the child curried out in relevant autologous serum seems to show a decreasing response during the course of pregnancy, in accordance with increasing tolerance of the fetal allograft. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Scandinavian Journal of Immunology Wiley

The Fetus as an Allograft: a Longitudinal Study of Normal Human Pregnancies Studied with Mixed Lymphocyte Cultures between Mother‐Father and Mother‐Child

Loading next page...
 
/lp/wiley/the-fetus-as-an-allograft-a-longitudinal-study-of-normal-human-qDHybpJxbz
Publisher
Wiley
Copyright
Copyright © 1980 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0300-9475
eISSN
1365-3083
DOI
10.1111/j.1365-3083.1980.tb00239.x
Publisher site
See Article on Publisher Site

Abstract

A longitudinal investigation of the mixed lymphocyte culture (MLC) response during pregnancy between mother and father, between mother and child, and between the mother and an indifferent lymphocyte pool has been carried out, using starting values before pregnancy and a cryobiological freezing system that allows in vitro playback of the immunological course of pregnancy. Lymphocyte and serum samples from twenty‐two pregnant women taken before and during pregnancy, at delivery, and after delivery were used. The study shows that the mother reacts during the course of pregnancy with an increasing MLC response to the father, which is replaced at delivery by a decrease in response and a subsequent increase after delivery. It is also shown that the mother reacts to the child in a similar manner at about half the level of reaction to the father. The mother also reacts similarly to a pool of indifferent lymphocytes. The MLC reactions mentioned are affected by both non‐pregnant and pregnant serum, leading to a moderation of the MLC reaction in relation to that carried out in neutral AB serum. In addition, there seems to be cooperation between cellular and humoral factors, since the MLC reaction to the child curried out in relevant autologous serum seems to show a decreasing response during the course of pregnancy, in accordance with increasing tolerance of the fetal allograft.

Journal

Scandinavian Journal of ImmunologyWiley

Published: Mar 1, 1980

References

  • Lymphocyte transformation with mitogen and antigens during normal human pregnancy: a longitudinal study
    Birkeland, Birkeland; Kristoffersen, Kristoffersen
  • The immunosuppressive role of alpha‐fetoprotein during pregnancy
    Murgita, Murgita
  • Joint report from a mixed lymphocyte culture workshop
    Thorsby, Thorsby; Bois, Bois; Bonnevik, Bonnevik; Dupost, Dupost; Eijsvoogel, Eijsvoogel; Hansen, Hansen; Jerslid, Jerslid; Jørgensen, Jørgensen; Kissmeyer‐Nielsen, Kissmeyer‐Nielsen; Lamm, Lamm; Schellekens, Schellekens; Svejgaard, Svejgaard; Thomsen, Thomsen

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off