The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment

The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308... This study aims to explore the expression of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nm excimer laser treatment. One hundred and sixty‐four vitiligo patients treated with 308 nm excimer laser were enrolled as Case group and 137 health examiners as Control group. Quantitative real‐time polymerase chain reaction and immunohistochemistry were conducted to detect the expressions of RORγt, BATF, and IL‐17. Expression of RORγt, BATF, IL‐17A, and IL‐17F were higher in Case group than Control group, with the diagnostic accuracy of 88.04, 87.38, 97.34, and 89.04%, respectively. Pearson correlation analysis showed a positive correlation in RORγt, BATF, IL‐17A, and IL‐17F mRNAs in vitiligo patients. Moreover, their expressions were higher in active vitiligo patients than stable ones. Besides, the expressions of RORγt, BATF, IL‐17A, and IL‐17F in vitiligo skin were significantly higher than those in non lesional skin and normal controls. After treatment, their expressions were significantly decreased. Active vitiligo and the high expressions of RORγt, BATF, and IL‐17F were the independent risk factors for the ineffectiveness of 308 nm excimer laser treatment. The expressions of RORγt, BATF, IL‐17 were significantly enhanced in vitiligo patients, which were correlated with the activity of vitiligo and 308 nm excimer laser therapeutic effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Dermatologic Therapy Wiley

The expression change of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nanometers excimer laser treatment

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Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1396-0296
eISSN
1529-8019
D.O.I.
10.1111/dth.12598
Publisher site
See Article on Publisher Site

Abstract

This study aims to explore the expression of RORγt, BATF, and IL‐17 in Chinese vitiligo patients with 308 nm excimer laser treatment. One hundred and sixty‐four vitiligo patients treated with 308 nm excimer laser were enrolled as Case group and 137 health examiners as Control group. Quantitative real‐time polymerase chain reaction and immunohistochemistry were conducted to detect the expressions of RORγt, BATF, and IL‐17. Expression of RORγt, BATF, IL‐17A, and IL‐17F were higher in Case group than Control group, with the diagnostic accuracy of 88.04, 87.38, 97.34, and 89.04%, respectively. Pearson correlation analysis showed a positive correlation in RORγt, BATF, IL‐17A, and IL‐17F mRNAs in vitiligo patients. Moreover, their expressions were higher in active vitiligo patients than stable ones. Besides, the expressions of RORγt, BATF, IL‐17A, and IL‐17F in vitiligo skin were significantly higher than those in non lesional skin and normal controls. After treatment, their expressions were significantly decreased. Active vitiligo and the high expressions of RORγt, BATF, and IL‐17F were the independent risk factors for the ineffectiveness of 308 nm excimer laser treatment. The expressions of RORγt, BATF, IL‐17 were significantly enhanced in vitiligo patients, which were correlated with the activity of vitiligo and 308 nm excimer laser therapeutic effects.

Journal

Dermatologic TherapyWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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