Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Mitra, M. Wong, MM Mozen, J. Mcdougal, J. Levy (1986)
Elimination of infectious retroviruses during preparation of immunoglobulinsTransfusion, 26
P. Foster, R. Mcintosh, A. Welch, J. Power, F. Davidson, J. O’Riordan, P. Simmonds, P. Yap, E. Lawlor (1995)
Hepatitis C infection from anti-D immunoglobulinThe Lancet, 346
R. Paine, C. Janeway (1952)
Human albumin infusions and homologous serum jaundice.Journal of the American Medical Association, 150 3
L. Ercoli, L. Sarmati, G. El-Sawaf, S. Cochi, T. Lanti, P. Iudicone, M. Guglielmetti, G. Giannini, C. Galluzzo, C. Tomino (1995)
Plasma viremia titration and RNA quantitation in ICD-p24 negative HIV type-1-infected patients.AIDS research and human retroviruses, 11 10
M. Wells, A. Wittek, J. Epstein, C. Marcus-Sekura, S. Daniel, D. Tankersley, M. Preston, G. Quinnan, (1986)
Inactivation and partition of human T‐cell lymphotrophic virus, type III, during ethanol fractionation of plasmaTransfusion, 26
S. Yei, Mei-ying Yu, DL Tankersley (1992)
Partitioning of hepatitis C virus during Cohn‐Oncley fractionation of plasmaTransfusion, 32
R. Murray, Frank Ratner (1953)
Safety of Immune Serum Globulin with Respect to Homologous Serum Hepatitis.∗Proceedings of the Society for Experimental Biology and Medicine, 83
R. Coombs, A. Collier, J. Allain, B. Nikora, M. Leuther, G. Gjerset, Lawrence Corey (1989)
Plasma viremia in human immunodeficiency virus infection.The New England journal of medicine, 321 24
R. Lane (1983)
NON-A, NON-B HEPATITIS FROM INTRAVENOUS IMMUNOGLOBULINThe Lancet, 322
C. Pattison, C. Klein, R. Leger, J. Maynard, K. Berquist, J. Hoofnagle, L. Barker, J. Bryan, D. Smith (1976)
An outbreak of type B hepatitis associated with transfusion of plasma protein fraction.American journal of epidemiology, 103 4
F Renger, H Porst, KH Frank (1981)
On the epidemiology, clinic, immunology and morphology of non‐A/non‐B hepatitis.Transfusion, 75
M. Davis, D. Mackay (1973)
Letter: Mentally subnormal children and their families.Lancet, 2 7835
RB Pennell (1957)
Hepatitis frontiers, a Henry Ford Hospital international symposiumJ Infect Dis
RS Remis, MV O'Shaughnessy, C Tsoukas (1990)
HIV transmission to patients with hemophilia by heat‐treated, donor‐screened factor concentrate.Vox Sang, 142
R. Murray, W. Diefenbach, H. Geller, N. Leone, F. Ratner (1955)
The problem of reducing the danger of serum; hepatitis from blood and blood products.New York state journal of medicine, 55 8
Z. Guo, M. Yu (1995)
Hepatitis C virus RNA in factor VIII concentratesTransfusion, 35
PR Foster, RV McIntosh, AG Welch (1995)
Hepatitis C infection from anti‐D immunoglobulin (letter).N Engl J Med, 346
J. Soulier, C. Blatix, A. Couroucé, D. Benamon, P. Amouch, J. Drouet (1972)
Prevention of virus B hepatitis (SH hepatitis).American journal of diseases of children, 123 4
MW Yu, BL Mason, S Yei, DL Tankersley (1994)
Viral hepatitis and liver diseaseLancet
J. Bresee, E. Mast, P. Coleman, M. Baron, L. Schonberger, M. Alter, M. Jonas, M. Yu, P. Renzi, L. Schneider (1996)
Hepatitis C virus infection associated with administration of intravenous immune globulin. A cohort study.JAMA, 276 19
C. Nübling, H. Willkommen, J. Löwer (1995)
Hepatitis C transmission associated with intravenous immunoglobulins.Lancet, 345 8958
(1981)
The chimpanzee animal model for nonA, non-B hepatitis: new applications
Robert Remis, Michael O'Shaughnessy, Chris Tsoukas, Gershon Growe, Martin Schechter, Robert Palmer, Dale Lawrence (1990)
HIV transmission to patients with hemophilia by heat-treated, donor-screened factor concentrate.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 142 11
J. Björkander, C. Cunningham-Rundles, P. Lundin, R. Olsson, R. Söderström, L. Hanson (1988)
Intravenous immunoglobulin prophylaxis causing liver damage in 16 of 77 patients with hypogammaglobulinemia or IgG subclass deficiency.The American journal of medicine, 84 1
L. Barker, R. Murray (1972)
Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis—associated antigenThe American Journal of the Medical Sciences, 263
M. Cardoso, K. Koerner, S. Epple, B. Kubanek (1996)
Safety of Blood Products Derived from Plasma Pools: The Positive Impact of Anti‐HCV Screening on the Quality of Such ProductsVox Sanguinis, 71
Y. Uemura, Y. Yang†, C. Heldebrant, K. Takechi, K. Yokoyama (1994)
Inactivation and Elimination of Viruses during Preparation of Human Intravenous ImmunoglobulinVox Sanguinis, 67
E Tabor, RJ Gerety (1982)
Viral hepatitis: 1981 International SymposiumN Engl J Med
T. Shikata, T. Karasawa, K. Abe, T. Takahashi, M. Mayumi, T. Oda (1978)
Incomplete inactivation of hepatitis B virus after heat treatment at 60 C for 10 hours.The Journal of infectious diseases, 138 2
Sydney Gellis, John Neefe, Joseph Stokes, Laurence Strong, Charles Janeway, George Scatchard (1948)
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVI. INACTIVATION OF THE VIRUS OF HOMOLOGOUS SERUM HEPATITIS IN SOLUTIONS OF NORMAL HUMAN SERUM ALBUMIN BY MEANS OF HEAT.The Journal of clinical investigation, 27 2
N Heimburger, H Schwinn, P Gratz (1981)
Factor VIII concentrate, highly purified and heated in solution, 31
M. Yu, B. Mason, S. Yei, D. Tankersley (1994)
Detection and Quantitation of HCV-RNA in Immune Globulins Produced by Cohn-Oncley Fractionation of Human Plasma
(1983)
Transcript of February 7, 1983 meeting
H. Alter, P. Holland, R. Purcell (1975)
The emerging pattern of post-transfusion hepatitis.The American journal of the medical sciences, 270 2
J Björkander, C Cunningham‐Rundles, P Lundin (1988)
Intravenous immunoglobulin prophylaxis causing liver damage in 16 of 77 patients with hypogammaglobulinemia or IgG subclass deficiency.N Engl J Med, 84
R. Gerety, L. Smallwood, E. Tabor (1980)
Hepatitis B immune globulin and immune serum globulin.The New England journal of medicine, 303 9
J. Saldanha, P. Minor (1996)
Incidence of Hepatitis C Virus RNA in Anti‐HCV‐Negative Plasma Pools and Blood ProductsVox Sanguinis, 70
E. Tabor, R. Gerety (1979)
TRANSMISSION OF HEPATITIS B BY IMMUNE SERUM GLOBULINThe Lancet, 314
M Piatak, LC Yang, KC Luk (1993)
Viral dynamics in primary HIV‐1 infection (letter).Lancet, 341
J. Bossell (1986)
Safety of Therapeutic Immune Globulin Preparations with Respect to Transmission of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus InfectionClinical Pediatrics, 25
(1981)
On the epidemiology, clinic, immunology and morphology of non-A/non-B hepatitis.] Z Arztl Fortbild (Berl) 1981;75:894-7 [NIH Library Translation #NIH 82-18
M. Piatak, K. Luk, M. Saag, J. Kappes, L. Yang, J. Lifson, S. Clark, B. Hahn, G. Shaw (1993)
Viral dynamics in primary HIV-1 infectionThe Lancet, 341
T. Zuck, M. Preston, D. Tankersley, M. Wells, A. Wittek, J. Epstein, S. Daniel, M. Phelan, G. Quinnan, (1986)
More on partitioning and inactivation of AIDS virus in immune globulin preparations.The New England journal of medicine, 314 22
W. Fricke, L. Augustynm, D. Lawrence, A. Brownstein, A. Kramer, B. Evatt (1992)
Human immunodeficiency virus infection due to clotting factor concentrates: results of the Seroconversion Surveillance ProjectTransfusion, 32
LF Barker, R Murray (1971)
Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis‐associated antigen.Am J Dis Child, 263
N. Heimburger, H. Schwinn, P. Gratz, G. Lüben, G. Kumpe, B. Herchenhan (1981)
[Factor VIII concentrate, highly purified and heated in solution (author's transl)].Arzneimittel-Forschung, 31 4
CP Pattison, CA Klein, RT Leger (1976)
Proceedings of the Workshop on AlbuminVox Sang
RS Lane (1983)
Non‐A, non‐B hepatitis from intravenous immunoglobulin (letter).MMWR Morb Mortal Wkly Rep, 2
D. Ho, T. Moudgil, M. Alam (1989)
Quantitation of human immunodeficiency virus type 1 in the blood of infected persons.The New England journal of medicine, 321 24
R Murray, WC Diefenbach (1953)
Effect of heat on the agent of homologous serum hepatitis.N Y State J Med, 84
CP Pattison, CA Klein, RT Leger (1976)
An outbreak of type B hepatitis associated with transfusion of plasma protein fraction.J Clin Invest, 103
J. Hoofnagle, J. Waggoner (1980)
Hepatitis A and B virus markers in immune serum globulin.Gastroenterology, 78 2
K. Cristiano, G. Pisani, M. Wirz, G. Gentili (1997)
Testing of immunoglobulin products for hepatitis C virus by polymerase chain reaction: importance of an internal controlTransfusion, 37
R. Murray, W. Diefenbach (1953)
Effect of Heat on the Agent of Homologous Serum Hepatitis.∗Proceedings of the Society for Experimental Biology and Medicine, 84
(1998)
Blood plasma safety : plasma product risks are low if good manufacturing practices are followed
(1982)
Transcript for December 4, 1982 meeting, 137
J. Power, E. Lawlor, F. Davidson, E. Holmes, P. Yap, P. Simmonds (1995)
Molecular epidemiology of an outbreak of infection with hepatitis C virus in recipients of anti-D immunoglobulinThe Lancet, 345
J. Hilfenhaus, A. Gröner, T. Nowak, T. Weimer (1997)
Analysis of human plasma products: polymerase chain reaction does not discriminate between live and inactivated virusesTransfusion, 37
JP Soulier, C Blatix, AM Courouce (1972)
Prevention of virus B hepatitis (SH hepatitis).Am J Epidemiol, 123
DL Tankersley, BL Mason, ZP Guo, MW Yu (1996)
Intravenous immunoglobulin research and therapyLancet
J. Morales, J. Campistol, M. Bruguera, A. Andrés, F. Oppenheimer, J. Rodicio (1995)
HCV and organ transplantationThe Lancet, 345
J., S. McDougal, L. Martin, S. Cort, M. Mozen, C. Heldebrant, B. Evatt (1985)
Thermal inactivation of the acquired immunodeficiency syndrome virus, human T lymphotropic virus-III/lymphadenopathy-associated virus, with special reference to antihemophilic factor.The Journal of clinical investigation, 76 2
B. Cuthbertson, R. Perry, P. Foster, K. Reid, R. Crawford, P. Yap (1987)
The viral safety of intravenous immunoglobulin.The Journal of infection, 15 2
(1980)
Factor VIII concentrate, hepatitis-safe: progress in the treatment of hemophilia A
Zuck Tf, P. Ms, Tankersley Dl, Wells Ma, A. Wittek, Epstein Je, S. Daniel, M. Phelan, G. Quinnan, (1986)
AIDS, blood transfusions, and directed donations.The New England Journal of Medicine, 314
A. Lever, David Brown, A. Webster, H. Thomas (1984)
NON-A, NON-B HEPATITIS OCCURRING IN AGAMMAGLOBULINAEMIC PATIENTS AFTER INTRAVENOUS IMMUNOGLOBULINThe Lancet, 324
SS Gellis, JR Neefe, J Stokes (1948)
, et al. Chemical, clinical and immunological studies on the products of human plasma fractionation. XXXVI. Inactivation of the virus of homologous serum hepatitis in solutions of normal human serum albumin by means of heat.Proc Soc Exp Biol Med, 27
K. Bjøro, S. Frøland, Z. Yun, H. Samdal, T. Haaland (1994)
Hepatitis C infection in patients with primary hypogammaglobulinemia after treatment with contaminated immune globulin.The New England journal of medicine, 331 24
R Murray, WC Diefenbach, H Geller (1955)
The problem of reducing the danger of serum hepatitis from blood and blood products.Am J Med Sci, 55
J. Finlayson, D. Tankersley (1990)
Anti-HCV screening and plasma fractionation: the case againstThe Lancet, 335
Lewellys Barker, James Maynard, Robert Purcell, Jay Hoofnagle, K. Berquist, W. London, R. Gerety, Krushak Dh (1975)
Hepatitis B virus infection in chimpanzees: titration of subtypes.The Journal of infectious diseases, 132 4
GV Quinnan, MA Wells, AE Wittek (1986)
Inactivation of human T‐cell lymphotropic virus, type III by heat, chemicals, and irradiation., 26
M. Piatak, M. Saag, Limei Yang, S. Clark, J. Kappes, K. Luk, B. Hahn, G. Shaw, J. Lifson (1993)
Determination of plasma viral load in HIV‐1 infection by quantitative competitive polymerase chain reactionAIDS, 7
RS Paine, CA Janeway (1952)
Human albumin infusions and homologous serum jaundice.J Clin Invest, 150
RW Coombs, AC Collier, JP Allain (1989)
Plasma viremia in human immunodeficiency virus infection.AIDS Res Hum Retroviruses, 321
E Tabor, RJ Gerety (1979)
Transmission of hepatitis B by immune serum globulin (letter).J Infect Dis, 2
H. Meisel, A. Reip, B. Faltus, D. Krüger, H. Porst, M. Wiese, M. Lu, Michael Roggendorf (1995)
Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulinThe Lancet, 345
RJ Gerety, LA Smallwood, E Tabor (1980)
Hepatitis B immune globulin and immune serum globulin (letter).Transfusion, 303
LF Barker, JE Maynard, RH Purcell (1975)
Hepatitis B virus infection in chimpanzees: titration of subtypes.Am J Med, 132
Therapeutic products made from human plasma provide life‐saving relief to hundreds of thousands of patients each year. The efficient production of these derivatives requires that they be made from large pools of human plasma, often comprising as many as 60,000 donations each. This review will examine the viruses that can be transmitted by plasma and for which sensitive detection systems and virus‐removal and ‐inactivation methods are available. The exclusion of plasma units that test positive for certain viral markers ensures that almost all units entering the pool are free of viruses. Each plasma donation is screened by using sensitive immunoassays to detect the presence of hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV types 1 and 2 (HIV‐1/2). Manufacturing steps for plasma products have been shown to remove or inactivate these viruses. Nevertheless, plasma units containing these viruses can enter the pool when a donor is in the window period of the disease, which is the short period during which the virus is present in the blood before the screening tests have become positive. At present, the screening of small pools of plasma (“minipools”) by using nucleic acid amplification assays such as polymerase chain reaction (PCR)
Transfusion – Wiley
Published: Jan 12, 1999
Keywords: ; ; ; ; ; ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.