The Epidemiology of Human T-lymphotropic Virus Types I and I1 J. E. Kaplan" and R. F. Khabbaz Refrovirus Diseases Branch, Division of Viral and Rickettsia1 Diseases, National Center for Infectious Diseases, Cenfers for Disease Control and Prevenfion, US Public Health Service, Department of Health and Human Services, Atlanfa, G A 30333, U S A INTRODUCTION Human T-lymphotropic virus type I (HTLV-I), the first human retrovirus to be discovered, was reported in 1980.' Shortly thereafter, its first disease association was established.Adult T-cell leukaemia/lymphoma (ATL),a lymphoproliferative malignancy first reported in Japan in 1977, was found to cluster in the same regions in Japanin which HTLVI is serological and virological evidence for an association between HTLV-I and ATL soon f o l l o ~ e d .In , ~ ~ 1985, a neurological disease, now called HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), was also found to be associated with HTLV-1.6 The closely related human T-lymphotropic virus type 1 (HTLV-11) 1 was discovered in 1982 and was initially thought to be associated with hairy cell le~kaemia.~ Despite these early findings, the HTLVs remained relatively unknown until a third human retrovirus, now called human immunodeficiency virus type 1 (HIV-1), was discovered to be
Reviews in Medical Virology – Wiley
Published: Sep 1, 1993
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