Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea‐pig airways

The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea‐pig airways The endogenous cannabinoid agonist, anandamide produced a modest contractile response in guinea‐pig isolated bronchus compared with the vanilloid receptor agonist capsaicin. The contractile response to both anandamide and capsaicin was inhibited by the vanilloid receptor antagonist, capsazepine. Furthermore, the NK2‐selective antagonist, SR48968 but not the NK1‐selective antagonist, SR140333 inhibited contractile responses to anandamide. The contractile response to anandamide was abolished in tissues desensitized by capsaicin. However, anandamide failed to cross‐desensitize the contractile response to capsaicin. The contractile response to anandamide was not significantly altered in the presence of the CB1 receptor antagonist, SR141716A, nor the amidase inhibitor, phenylmethylsulphonyl fluoride (PMSF) but was significantly increased in the presence of the neutral endopeptidase inhibitor, thiorphan. The cannabinoid agonist, CP55,940 failed to significantly attenuate the excitatory non‐adrenergic non‐cholinergic (eNANC) response in guinea‐pig airways. In contrast, the ORL1 receptor agonist, nociceptin, significantly inhibited this response. The results demonstrate that anandamide induces a modest contractile response in guinea‐pig isolated bronchus that is dependent upon the activation of vanilloid receptors on airway sensory nerves. However, cannabinoid receptors do not appear to play a role in this regard, nor in regulating the release of neuropeptides from airway sensory nerves under physiological conditions. British Journal of Pharmacology (2001) 132, 1127–1135; doi:10.1038/sj.bjp.0703906 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea‐pig airways

Download PDF
9 pages
Read Article

Loading next page...
 
/lp/wiley/the-endogenous-cannabinoid-agonist-anandamide-stimulates-sensory-sYE8XMT3nB
Publisher
Wiley
Copyright
2001 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1038/sj.bjp.0703906
pmid
11226144
Publisher site
See Article on Publisher Site

Abstract

The endogenous cannabinoid agonist, anandamide produced a modest contractile response in guinea‐pig isolated bronchus compared with the vanilloid receptor agonist capsaicin. The contractile response to both anandamide and capsaicin was inhibited by the vanilloid receptor antagonist, capsazepine. Furthermore, the NK2‐selective antagonist, SR48968 but not the NK1‐selective antagonist, SR140333 inhibited contractile responses to anandamide. The contractile response to anandamide was abolished in tissues desensitized by capsaicin. However, anandamide failed to cross‐desensitize the contractile response to capsaicin. The contractile response to anandamide was not significantly altered in the presence of the CB1 receptor antagonist, SR141716A, nor the amidase inhibitor, phenylmethylsulphonyl fluoride (PMSF) but was significantly increased in the presence of the neutral endopeptidase inhibitor, thiorphan. The cannabinoid agonist, CP55,940 failed to significantly attenuate the excitatory non‐adrenergic non‐cholinergic (eNANC) response in guinea‐pig airways. In contrast, the ORL1 receptor agonist, nociceptin, significantly inhibited this response. The results demonstrate that anandamide induces a modest contractile response in guinea‐pig isolated bronchus that is dependent upon the activation of vanilloid receptors on airway sensory nerves. However, cannabinoid receptors do not appear to play a role in this regard, nor in regulating the release of neuropeptides from airway sensory nerves under physiological conditions. British Journal of Pharmacology (2001) 132, 1127–1135; doi:10.1038/sj.bjp.0703906

Journal

British Journal of Pharmacology – Wiley

Published: Mar 1, 2001

References

  • Capsazepine as a selective antagonist of capsaicin‐induced activation of C‐fibres in guinea‐pig bronchi
    BELVISI, BELVISI; MIURA, MIURA; STRETTON, STRETTON; BARNES, BARNES
  • Antagonism of an indirectly acting agonist: Block by propranolol and sotalol of the action of tyramines on rat heart
    BLACK, BLACK; JENKINSON, JENKINSON; KENAKIN, KENAKIN
  • Bidirectional control of airway responsiveness by endogenous cannabinoids
    CALIGNANO, CALIGNANO; KATONA, KATONA; DESARNAUD, DESARNAUD; GIUFFRIDA, GIUFFRIDA; LA RANA, LA RANA; MACKIE, MACKIE; FREUND, FREUND; PIOMELLI, PIOMELLI
  • Control of pain initiation by endogenous cannabinoids
    CALIGNANO, CALIGNANO; LA RANA, LA RANA; GIUFFRIDA, GIUFFRIDA; PIOMELLI, PIOMELLI
  • The capsaicin receptor: a heat‐activated ion channel in the pain pathway
    CATERINA, CATERINA; SCHUMACHER, SCHUMACHER; TOMINAGA, TOMINAGA; ROSEN, ROSEN; LEVINE, LEVINE; JULIUS, JULIUS
  • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    DEVANE, DEVANE; HANUS, HANUS; BREUER, BREUER; PERTWEE, PERTWEE; STEVENSON, STEVENSON; GRIFFIN, GRIFFIN; GIBSON, GIBSON; MANDELBAUM, MANDELBAUM; ETINGER, ETINGER; MECHOULAM, MECHOULAM
  • Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N‐18 neuroblastoma cells
    DIMARZO, DIMARZO; DEPETROCELLIS, DEPETROCELLIS; SEPE, SEPE; BUONO, BUONO
  • NE‐19550 and NE‐21610, antinociceptive capsaicin analogues: studies on nociceptive fibres of the neonatal rat tail vein in vitro
    DRAY, DRAY; BETTANEY, BETTANEY; RUEFF, RUEFF; WALPOLE, WALPOLE; WRIGGLESWORTH, WRIGGLESWORTH
  • Inhibition by capsazepine of resiniferatoxin and capsaicin‐induced contractions of guinea‐pig trachea
    ELLIS, ELLIS; UNDEM, UNDEM
  • LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to a stimulation of cAMP accumulation
    FELDER, FELDER; JOYCE, JOYCE; BRILEY, BRILEY; GLASS, GLASS; MACKIE, MACKIE; FAHEY, FAHEY; CULLINAN, CULLINAN; HUNDEN, HUNDEN; JOHNSON, JOHNSON; CHANEY, CHANEY; KOPPEL, KOPPEL; BROWNSTEIN, BROWNSTEIN
  • Multiple tachykinin pools in sensory nerve fibres in the rabbit iris
    HAKANSON, HAKANSON; BEDING, BEDING; EKMAN, EKMAN; HEILIG, HEILIG; WAHLESTEDT, WAHLESTEDT; SUNDLER, SUNDLER
  • The effect of okadaic acid on non‐adrenergic non‐cholinergic contraction in guinea‐pig isolated bronchus
    HARRISON, HARRISON; SPINA, SPINA; PAGE, PAGE
  • Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: A double‐label in situ hybridization study
    HOHMANN, HOHMANN; HERKENHAM, HERKENHAM
  • Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin‐like substances
    HWANG, HWANG; CHO, CHO; KWAK, KWAK; LEE, LEE; KANG, KANG; JUNG, JUNG; CHO, CHO; MIN, MIN; SUH, SUH; KIM, KIM; OH, OH
  • Excitatory transmission to the circular muscle of the guinea‐pig ileum: evidence for the involvement of cannabinoid CB 1 receptors
    IZZO, IZZO; MASCOLOL, MASCOLOL; BORRELLI, BORRELLI; CAPASSO, CAPASSO
  • Pharmacological characterisation of cannabinoid CB 1 receptors in the rat and mouse
    LAY, LAY; ANGUS, ANGUS; WRIGHT, WRIGHT
  • Localization of cannabinoid receptors and nonsaturable high‐density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor‐mediated immune modulation by cannabinoids
    LYNN, LYNN; HERKENHAM, HERKENHAM
  • The effect of thiorphan and epithelium removal on contractions and tachykinin release produced by activation of capsaicin‐sensitive afferents in the guinea‐pig isolated bronchus
    MAGGI, MAGGI; PATACCHINI, PATACCHINI; PERRETTI, PERRETTI; MEINI, MEINI; MANZINI, MANZINI; SANTICIOLI, SANTICIOLI; DEL BIANCO, DEL BIANCO; MELI, MELI
  • Arachidonic acid‐induced bronchomotor responses are partially mediated by release of sensory neuropeptides from capsaicin‐sensitive structures
    MANZINI, MANZINI; BALLATI, BALLATI; GEPPETTI, GEPPETTI; RUBINI, RUBINI; MEINI, MEINI; PERRETTI, PERRETTI
  • Involvement of capsaicin‐sensitive nerves in the bronchomotor effects of arachidonic acid and melittin: A possible role for Lipoxin A4
    MANZINI, MANZINI; MEINI, MEINI
  • Prostacyclin activates tachykinin release from capsaicin‐sensitive afferents in guinea‐pig bronchi through a ruthenium red‐sensitive pathway
    MAPP, MAPP; FABBRI, FABBRI; BONIOTTI, BONIOTTI; MAGGI, MAGGI
  • Pharmacologic and neurochemical evidence for the activation of capsaicin‐sensitive sensory nerves by lipoxin A in guinea pig bronchus
    MEINI, MEINI; EVANGELISTA, EVANGELISTA; GEPPETTI, GEPPETTI; SZALLASI, SZALLASI; BLUMBERG, BLUMBERG; MANZINI, MANZINI
  • Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations
    PERTWEE, PERTWEE; FERNANDO, FERNANDO; GRIFFIN, GRIFFIN; ABADJI, ABADJI; MAKRIYANNIS, MAKRIYANNIS
  • Further evidence for the presence of cannabinoid CB 1 receptors in guinea‐pig small intestine
    PERTWEE, PERTWEE; FERNANDO, FERNANDO; NASH, NASH; COUTTS, COUTTS
  • The effect of neonatal capsaicin on the development of bronchial hyperresponsiveness in allergic rabbits
    RICCIO, RICCIO; MANZINI, MANZINI; PAGE, PAGE
  • The effect of 15‐HPETE on airway responsiveness and pulmonary cell recruitment in rabbits
    RICCIO, RICCIO; MATSUMOTO, MATSUMOTO; ADCOCK, ADCOCK; DOUGLAS, DOUGLAS; SPINA, SPINA; PAGE, PAGE
  • Antihyperalgesic effects of spinal cannabinoids
    RICHARDSON, RICHARDSON; AANONSEN, AANONSEN; HARGREAVES, HARGREAVES
  • Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
    RICHARDSON, RICHARDSON; KILO, KILO; HARGREAVES, HARGREAVES
  • Nociceptin inhibits non‐adrenergic non‐cholinergic contraction in guinea‐pig airway
    SHAH, SHAH; PAGE, PAGE; SPINA, SPINA
  • The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
    SMART, SMART; GUNTHORPE, GUNTHORPE; JERMAN, JERMAN; NASIR, NASIR; GRAY, GRAY; MUIR, MUIR; CHAMBERS, CHAMBERS; RANDALL, RANDALL; DAVIS, DAVIS
  • Characterization of the effects of cannabinoids on guinea‐pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves
    SPICUZZA, SPICUZZA; HADDAD, HADDAD; BIRRELL, BIRRELL; CLARKE, CLARKE; VENKATESAN, VENKATESAN; BARNES, BARNES; BELVISI, BELVISI
  • Regulation by phosphodiesterase isoenzymes of nonadrenergic noncholinergic contraction in guinea‐pig isolated main bronchus
    SPINA, SPINA; HARRISON, HARRISON; PAGE, PAGE
  • Modulation of sensory nerve function in the airways
    SPINA, SPINA; HARRISON, HARRISON; SHAH, SHAH
  • Effect of capsaicin on PAF‐induced bronchial hyperresponsiveness and pulmonary cell accumulation in the rabbit
    SPINA, SPINA; MCKENNIFF, MCKENNIFF; COYLE, COYLE; SEEDS, SEEDS; TRAMONTANA, TRAMONTANA; PERRETTI, PERRETTI; MANZINI, MANZINI; PAGE, PAGE
  • Pulmonary actions of anandamide, an endogenous cannabinoid receptor agonist, in guinea‐pigs
    STENGEL, STENGEL; RIPPY, RIPPY; COCKERMAN, COCKERMAN; DEVAN, DEVAN; SILBAUGH, SILBAUGH
  • Bradykinin increases the proportion of neonatal rat dorsal root ganglion neurons that respond to capsaicin and protons
    STUCKY, STUCKY; ABRAHAMS, ABRAHAMS; SEYBOLD, SEYBOLD
  • Evidence that 2‐arachidonoylglycerol but not N‐Palmitoyethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor
    SUGIURA, SUGIURA; KONDO, KONDO; KISHIMOTO, KISHIMOTO; MIYASHITA, MIYASHITA; NAKANE, NAKANE; ODAKA, ODAKA; SUHARA, SUHARA; TAKAYAMA, TAKAYAMA; WAKU, WAKU
  • Vanilloid (Capsaicin) receptors and mechnisms
    SZALLASI, SZALLASI; BLUMBERG, BLUMBERG
  • The cloned capsaicin receptor integrates multiple pain‐producing stimuli
    TOMINAGA, TOMINAGA; CATERINA, CATERINA; MALMBERG, MALMBERG; ROSEN, ROSEN; GILBERT, GILBERT; SKINNER, SKINNER; RAUMANN, RAUMANN; BASBAUM, BASBAUM; JULIUS, JULIUS
  • Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats
    VYKLICKY, VYKLICKY; KNOTKOVA‐URBANCOVA, KNOTKOVA‐URBANCOVA; VITASKOVA, VITASKOVA; VLACHOVA, VLACHOVA; KRESS, KRESS; REEH, REEH
  • Mesenteric vasodilation mediated by endothelial anandamide receptors
    WAGNER, WAGNER; VARGA, VARGA; JARAI, JARAI; KUNOS, KUNOS
  • Pain modulation by release of the endogenous cannabinoid anandamide
    WALKER, WALKER; HUANG, HUANG; STRANGMAN, STRANGMAN; TSOU, TSOU; SANUDO‐PENA, SANUDO‐PENA
  • Pharmacological characterization of the vanilloid receptor in the rat vas deferens
    WARDLE, WARDLE; FUREY, FUREY; SANGER, SANGER
  • The actions of the cannabinoid receptor antagonist, SR141716A, in the rat isolated mesenteric artery
    WHITE, WHITE; HILEY, HILEY
  • Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    ZYGMUNT, ZYGMUNT; PETERSSON, PETERSSON; ANDERSSON, ANDERSSON; CHUANG, CHUANG; SORGARD, SORGARD; DIMARZO, DIMARZO; JULIUS, JULIUS; HOGESTATT, HOGESTATT

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial