TASK‐1 encodes an acid‐ and anaesthetic‐sensitive background K+ current, which sets the resting membrane potential of both cerebellar granule neurons and somatic motoneurons. We demonstrate that TASK‐1, unlike the other two pore (2P) domain K+ channels, is directly blocked by submicromolar concentrations of the endocannabinoid anandamide, independently of the CB1 and CB2 receptors. In cerebellar granule neurons, anandamide also blocks the TASK‐1 standing‐outward K+ current, IKso, and induces depolarization. Anandamide‐induced neurobehavioural effects are only partly reversed by antagonists of the cannabinoid receptors, suggesting the involvement of alternative pathways. TASK‐1 constitutes a novel sensitive molecular target for this endocannabinoid.
The EMBO Journal – Wiley
Published: Mar 15, 2002
Keywords: ; ; ;
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