The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride

The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride Abstract— Cisplatin administered by either the intravenous (i.v.) or intra‐cerebroventricular (i.c.v.) route produced emesis in cats. The average time to onset of emesis was decreased significantly (4.0 min versus 100.6 min) when cisplatin was administered i.c.v. Zacopride administered either i.c.v. (0.02 mg) or i.v. (0.1 mg kg−1) completely blocked the emesis due to cisplatin given by either route. Their data show that cisplatin possesses a central emetic component and that this is blocked by zacopride. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science Wiley

The emetic activity of centrally administered cisplatin in cats and its antagonism by zacopride

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Publisher
Wiley
Copyright
1988 Royal Pharmaceutical Society of Great Britain
ISSN
0022-3573
eISSN
2042-7158
DOI
10.1111/j.2042-7158.1988.tb05202.x
Publisher site
See Article on Publisher Site

Abstract

Abstract— Cisplatin administered by either the intravenous (i.v.) or intra‐cerebroventricular (i.c.v.) route produced emesis in cats. The average time to onset of emesis was decreased significantly (4.0 min versus 100.6 min) when cisplatin was administered i.c.v. Zacopride administered either i.c.v. (0.02 mg) or i.v. (0.1 mg kg−1) completely blocked the emesis due to cisplatin given by either route. Their data show that cisplatin possesses a central emetic component and that this is blocked by zacopride.

Journal

Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical ScienceWiley

Published: Feb 1, 1988

References

  • Inhibition of cisplatin‐induced vomiting by selective 5‐hydroxytryptamine M‐receptor antagonism
    Miner, Miner; Sanger, Sanger
  • Fundamental studies with cisplatin
    Rosenberg, Rosenberg

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