The effects of slow infusion of a low dosage of endotoxin in healthy horses

The effects of slow infusion of a low dosage of endotoxin in healthy horses Summary The effects of slow intravenous (iv) infusion of a very low dosage of endotoxin (a cumulative dosage of 0.03 μg/kg bodyweight (bwt) infused over 60 mins) were evaluated in six conscious healthy horses. Duodenal, right ventral colon, and caecal contractions were detected with strain gauge force transducers. Lateral caecal arterial blood flow was measured using transit time ultrasonic blood flow probes. Duodenal contractile activity was not significantly altered by infusion of endotoxin. In contrast, the contractile activity of the right ventral colon 90 and 270 mins after infusion of endotoxin was less than after infusion of saline solution (control). The contractile activity of the caecal body 30, 60, 90, 120 and 240 mins after infusion of endotoxin was significantly less than control. The contractile activity of the caecal apex 60, 90, 120, 240 and 270 mins after termination of endotoxin infusion was significantly less than control. Lateral caecal arterial blood flow was significantly less than control at the end of endotoxin infusion and at 30, 45, 60, 90, 105 and 120 mins afterwards. Average carotid arterial pressure was significantly greater than control at 210, 225, 240, 255 and 270 mins after endotoxin infusion. Infusion of endotoxin increased heart rate, respiratory rate and body temperature significantly. The decrease in caecal contractile activity occurred before the increase in body temperature. All horses became depressed and developed injected mucous membranes. Signs of abdominal pain (including stretching, pawing, kicking at abdomen) were seen in four of the six horses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Equine Veterinary Journal Wiley

The effects of slow infusion of a low dosage of endotoxin in healthy horses

Equine Veterinary Journal, Volume 21 (S7) – Jun 1, 1989

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Publisher
Wiley
Copyright
1989 EVJ Ltd
ISSN
0425-1644
eISSN
2042-3306
DOI
10.1111/j.2042-3306.1989.tb05652.x
Publisher site
See Article on Publisher Site

Abstract

Summary The effects of slow intravenous (iv) infusion of a very low dosage of endotoxin (a cumulative dosage of 0.03 μg/kg bodyweight (bwt) infused over 60 mins) were evaluated in six conscious healthy horses. Duodenal, right ventral colon, and caecal contractions were detected with strain gauge force transducers. Lateral caecal arterial blood flow was measured using transit time ultrasonic blood flow probes. Duodenal contractile activity was not significantly altered by infusion of endotoxin. In contrast, the contractile activity of the right ventral colon 90 and 270 mins after infusion of endotoxin was less than after infusion of saline solution (control). The contractile activity of the caecal body 30, 60, 90, 120 and 240 mins after infusion of endotoxin was significantly less than control. The contractile activity of the caecal apex 60, 90, 120, 240 and 270 mins after termination of endotoxin infusion was significantly less than control. Lateral caecal arterial blood flow was significantly less than control at the end of endotoxin infusion and at 30, 45, 60, 90, 105 and 120 mins afterwards. Average carotid arterial pressure was significantly greater than control at 210, 225, 240, 255 and 270 mins after endotoxin infusion. Infusion of endotoxin increased heart rate, respiratory rate and body temperature significantly. The decrease in caecal contractile activity occurred before the increase in body temperature. All horses became depressed and developed injected mucous membranes. Signs of abdominal pain (including stretching, pawing, kicking at abdomen) were seen in four of the six horses.

Journal

Equine Veterinary JournalWiley

Published: Jun 1, 1989

References

  • Dose‐related effects of isoflurane on superior mesenteric vasoconstriction induced by endotoxemia in the rat
    Biber, Biber; Schaeffer, Schaeffer; Smolik, Smolik; Lawrence, Lawrence; Lerner, Lerner; Brackett, Brackett; Wilson, Wilson; Fagraeus, Fagraeus
  • Effect of experimental vascular occlusion on small intestinal motility in ponies
    Davies, Davies; Gerring, Gerring
  • Incidence, diagnosis, and treatment of postoperative complications in colic cases
    Hunt, Hunt; Edwards, Edwards; Clarke, Clarke
  • Effects of flunixin meglumine in cardiopulmonary responses to endotoxin in ponies
    Olson, Olson; Meyer, Meyer; Anderson, Anderson

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