The effect of the acute phase response (APR) on laboratory biomarkers of iron status is well known, and typically shows increased serum ferritin and decreased serum iron, transferrin, total iron‐binding capacity (TIBC) and transferrin saturation. In contrast, there are limited and conflicting data on the effect of the APR on serum biomarkers of vitamin B12 and folate. Serum total B12 has been reported as unaffected by surgery, but the high total serum B12 seen in malignancies, inflammatory diseases and the critically ill has been attributed by most but not all as being due to inflammation. Similarly, serum folate has been reported as reduced or unaffected by surgery. There are no prospective data on the effect of the APR on serum active B12 or methylmalonic acid (MMA). We, therefore, prospectively evaluated the effect of the APR, as provoked by elective orthopaedic surgery, on laboratory biomarkers of iron, vitamin B12 and folate status to establish their validity in acute illness.Thirty patients (14 male) aged 70.0 (9.4) years gave informed written consent to participate in this study approved by the National Research Ethics Service. Exclusion criteria included patients who received a blood transfusion within 3 months, known to have haematological and liver disorders
International Journal of Laboratory Hematology – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera