THE EFFECT OF INTRAHIPPOCAMPAL KAINIC ACID INJECTIONS AND SURGICAL LESIONS ON NEUROTRANSMITTERS IN HIPPOCAMPUS AND SEPTUM

THE EFFECT OF INTRAHIPPOCAMPAL KAINIC ACID INJECTIONS AND SURGICAL LESIONS ON NEUROTRANSMITTERS... Local injection of kainic acid (2 μg) was accompanied by destruction of intrinsic neurons in the dorsal part of hippocampus. The lesion was accompanied by a 75% reduction in glutamate decarboxylase activity, a 60% reduction in the high affinity uptake of l‐glutamate, a 40‐60% reduction in the endogeneous levels of aspartate, glutamate and GABA and no changes in the activities of choline acetyltransferase or aromatic amino acid decarboxylase in the dorsal hippocampus. Unilateral destruction of neurons in the dorsal hippocampus was followed by a 20‐40% reduction in the high affinity uptake of glutamate in lateral, but not in medial septum, on both sides. There was no reduction in choline acetyltransferase, glutamate decarboxylase or aromatic amino acid decarboxylase activities in the lateral or medial part of the septum. Transection of fimbria and superior fornix was accompanied by a severe reduction in choline acetyltransferase and aromatic amino acid decarboxylase activity in hippocampus, in the high affinity uptake of glutamate and in the endogenous level of glutamate in the lateral septum. The results are consistent with the concept that in the hippocampus kainic acid destroys intrinsic neurons and not afferent fibres. It seems therefore that all GABAergic fibres in the hippocampus belong to intrinsic neurons whereas glutamergic and aspartergic neurons belong partly to local neurons. The connection from the hippocampus to the lateral septum probably uses glutamate as a transmitter. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurochemistry Wiley

THE EFFECT OF INTRAHIPPOCAMPAL KAINIC ACID INJECTIONS AND SURGICAL LESIONS ON NEUROTRANSMITTERS IN HIPPOCAMPUS AND SEPTUM

Journal of Neurochemistry, Volume 31 (5) – Nov 1, 1978

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Publisher
Wiley
Copyright
Copyright © 1978 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0022-3042
eISSN
1471-4159
D.O.I.
10.1111/j.1471-4159.1978.tb06241.x
Publisher site
See Article on Publisher Site

Abstract

Local injection of kainic acid (2 μg) was accompanied by destruction of intrinsic neurons in the dorsal part of hippocampus. The lesion was accompanied by a 75% reduction in glutamate decarboxylase activity, a 60% reduction in the high affinity uptake of l‐glutamate, a 40‐60% reduction in the endogeneous levels of aspartate, glutamate and GABA and no changes in the activities of choline acetyltransferase or aromatic amino acid decarboxylase in the dorsal hippocampus. Unilateral destruction of neurons in the dorsal hippocampus was followed by a 20‐40% reduction in the high affinity uptake of glutamate in lateral, but not in medial septum, on both sides. There was no reduction in choline acetyltransferase, glutamate decarboxylase or aromatic amino acid decarboxylase activities in the lateral or medial part of the septum. Transection of fimbria and superior fornix was accompanied by a severe reduction in choline acetyltransferase and aromatic amino acid decarboxylase activity in hippocampus, in the high affinity uptake of glutamate and in the endogenous level of glutamate in the lateral septum. The results are consistent with the concept that in the hippocampus kainic acid destroys intrinsic neurons and not afferent fibres. It seems therefore that all GABAergic fibres in the hippocampus belong to intrinsic neurons whereas glutamergic and aspartergic neurons belong partly to local neurons. The connection from the hippocampus to the lateral septum probably uses glutamate as a transmitter.

Journal

Journal of NeurochemistryWiley

Published: Nov 1, 1978

References

  • The structural specificity of the high affinity uptake of l‐glutamate and l‐aspartate by rat brain slices
    Balcar, Balcar; Johnston, Johnston
  • The regional and subcellular distribution of catechol‐ O ‐methyl transferase in the rat brain
    Broch, Broch; Fonnum, Fonnum
  • Electrophysiological analysis of the hippocampal‐septal projections: II. Functional characteristics
    DeFrance, DeFrance; Kitai, Kitai; Shimonu, Shimonu
  • Topographical and subcellular localization of choline acetyltransferase in rat hippocampal region
    Fonnum, Fonnum
  • Localization of GABAergic, cholinergic and aminergic structures in the mesolimbic system
    Fonnum, Fonnum; Walaas, Walaas; Iversen, Iversen
  • The toxic effect of sodium glutamate on rat retina: changes in putative transmitters and their corresponding enzymes
    Karlsen, Karlsen; Fonnium, Fonnium
  • The hippocampal control of neuronal discharges in the septum of the rat
    McLennan, McLennan; Miller, Miller
  • Quantitative histochemistry of glutamate decarboxylase in the rat hippocampal region
    Storm‐Mathisen, Storm‐Mathisen; Fonnum, Fonnum

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