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The effect of GR38032F, novel 5‐HT 3 ‐receptor antagonist on gastric emptying in the guinea‐pig

The effect of GR38032F, novel 5‐HT 3 ‐receptor antagonist on gastric emptying in the guinea‐pig The effects of GR38032F a novel, selective and potent 5‐hydroxytryptamine (5‐HT3)‐receptor antagonist on gastric emptying in the guinea‐pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose‐dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

The effect of GR38032F, novel 5‐HT 3 ‐receptor antagonist on gastric emptying in the guinea‐pig

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Publisher
Wiley
Copyright
1987 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1987.tb10280.x
Publisher site
See Article on Publisher Site

Abstract

The effects of GR38032F a novel, selective and potent 5‐hydroxytryptamine (5‐HT3)‐receptor antagonist on gastric emptying in the guinea‐pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose‐dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.

Journal

British Journal of PharmacologyWiley

Published: Jun 1, 1987

References

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