Brain and Behavior. 2018;8:e00975.
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The effect of a single dose of escitalopram on sensorimotor
* | Georg Kägi
* | Werner Krammer
| Chin B. Eap
| John H. Missimer
| Bruno J. Weder
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited.
© 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
*Christian Weisstanner and Georg Kägi share first authorship.
†John H. Missimer and Bruno J. Weder share senior authorship.
Support Center for Advanced Imaging
(SCAN), Department of Diagnostic
and Interventional Neuroradiology,
Inselspital, Bern University Hospital, Bern,
Department of Neurology, Kantonsspital St.
Gallen, St. Gallen, Switzerland
Unit of Pharmacogenetics and Clinical
of Psychiatry, Center for Psychiatric
Neuroscience, Lausanne University Hospital,
School of Pharmaceutical
Sciences, University of Geneva and
University of Lausanne, Geneva, Switzerland
Laboratory of Biomolecular Research, Paul
Scherrer Institute (PSI), Villigen, Switzerland
Bruno J. Weder, Support Center for
Advanced Imaging (SCAN), Department
of Diagnostic and Interventional
Neuroradiology, Inselspital, Bern University
Hospital, Bern, Switzerland.
Medical Research Center of Kantonsspital
Introduction: Serving as a pilot study of poststroke pharmacotherapy, the present
investigation was intended to establish the effect of a single dose of escitalopram on
motor task performance in normal volunteers.
of 20 mg escitalopram or placebo presented in pseudorandom order. The fMRI image
sequences were submitted to principal component analysis (PCA).
mean component images derived in our previous study, we established the reproduc-
ibility of two networks of sensorimotor activity proposed there. The network reflect-
ing motor control (cerebral pattern I) appeared invariably in placebo and verum
conditions. In contrast, the other network, attributed to diminished motor control
due to distracting mental processing (cerebral pattern II), emerged less regularly and
ingsofthe initialanalysis.Specifically,itvalidated the dominant and invariableex-
pression of cerebral pattern I after application of a single dose of escitalopram.
Dynamic causal modeling confirmed enhanced motor output as a result of a signifi-
cantlyincreased connectivitybetween primarymotor cortex and dorsal premotor
Conclusion: This pilot study suggests the promise of stimulation by a specific seroto-
nin reuptake inhibitor in regard to recovery and preservation of motor control after
dynamic causal modeling, escitalopram, fMRI, motor control, principal component analysis,