The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers

The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers Carbonic anhydrases (CAs) play an important function in various physiological and pathological processes. Therefore, many researchers work in this field in order to design and synthesize new drugs. Both inhibitors and activators of CAs, which are associated with the diagnosis and treatment of many diseases, are very important. The emergence of the use of CA activators in the treatment of Alzheimer has led many scholars to work on this issue. In this study, CA activators and inhibitors are determined. The crown ethers compounds (1, 2, 3, 6, 7, 8, and 9) were found to cause activation on enzyme activities of hCA I and II. The AC50 values on hCA I and II of the compounds are in the range of 4.6565–374.979 μM. The 4 (IC50; 1.301 and 3.215 μM for hCA I and II) and 5 (IC50; 73.96 and 378.5 μM for hCA I and II) compounds were found to cause inhibition on enzyme activities of hCA I and II. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biochemical and Molecular Toxicology (Formerly Journal of Biochemical Toxicology) Wiley

The determination of the carbonic anhydrases activators in vitro effect of mixed donor crown ethers

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2018 Wiley Periodicals, Inc.
ISSN
1095-6670
eISSN
1099-0461
D.O.I.
10.1002/jbt.22032
Publisher site
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Abstract

Carbonic anhydrases (CAs) play an important function in various physiological and pathological processes. Therefore, many researchers work in this field in order to design and synthesize new drugs. Both inhibitors and activators of CAs, which are associated with the diagnosis and treatment of many diseases, are very important. The emergence of the use of CA activators in the treatment of Alzheimer has led many scholars to work on this issue. In this study, CA activators and inhibitors are determined. The crown ethers compounds (1, 2, 3, 6, 7, 8, and 9) were found to cause activation on enzyme activities of hCA I and II. The AC50 values on hCA I and II of the compounds are in the range of 4.6565–374.979 μM. The 4 (IC50; 1.301 and 3.215 μM for hCA I and II) and 5 (IC50; 73.96 and 378.5 μM for hCA I and II) compounds were found to cause inhibition on enzyme activities of hCA I and II.

Journal

Journal of Biochemical and Molecular Toxicology (Formerly Journal of Biochemical Toxicology)Wiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

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