Introduction Although a very useful and important group of medications used in equine medicine, glucocorticoids have been suggested by some authors to be associated with the risk of inducing acute laminitis when administered systemically (Lose 1980; Lawrence et al. 1985; Eustace and Redden 1990; Frederick and Kehl 2000; Ryu et al. 2004). This link has not been proven experimentally. Whether or not this might involve a direct effect of these drugs and, further, whether the risk is significant enough in the clinical setting to affect how and when these drugs are used, is currently a matter for debate. The report of a recent high-profile case, described in this issue (Dutton 2007), once again brings these questions into the spotlight. Evidence directly linking the administration of corticosteroids with the induction of laminitis is scarce. The reader is referred to previous reviews of the possible links between glucocorticoid therapy and laminitis (Johnson et al. 2002; Cornelisse and Robinson 2004). This review seeks to update the current evidence base on this subject, so that the potential risk of inducing laminitis by the systemic use of glucocorticoids can be more accurately assessed. Areas where further research is needed (epidemiological, clinical and/or on
Equine Veterinary Journal – Wiley
Published: Jan 1, 2007
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