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The complications of promiscuity: endocannabinoid action and metabolism

The complications of promiscuity: endocannabinoid action and metabolism In this review, we present our understanding of the action and metabolism of endocannabinoids and related endogenous molecules. It is clear that the interactions between the multiple endocannabinoid‐like molecules (ECLs) are highly complex, both at the level of signal transduction and metabolism. Thus, ECLs are a group of ligands active at 7‐transmembrane and nuclear receptors, as well as transmitter‐gated and ion channels. ECLs and their metabolites can converge on common endpoints (either metabolic or signalling) through contradictory or reinforcing pathways. We highlight the complexity of the endocannabinoid system, based on the promiscuous nature of ECLs and their metabolites, as well as the synthetic modulators of the endocannabinoid system. British Journal of Pharmacology (2007) 152, 602–623; doi:10.1038/sj.bjp.0707456; published online 17 September 2007 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

The complications of promiscuity: endocannabinoid action and metabolism

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Publisher
Wiley
Copyright
2007 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1038/sj.bjp.0707456
pmid
17876303
Publisher site
See Article on Publisher Site

Abstract

In this review, we present our understanding of the action and metabolism of endocannabinoids and related endogenous molecules. It is clear that the interactions between the multiple endocannabinoid‐like molecules (ECLs) are highly complex, both at the level of signal transduction and metabolism. Thus, ECLs are a group of ligands active at 7‐transmembrane and nuclear receptors, as well as transmitter‐gated and ion channels. ECLs and their metabolites can converge on common endpoints (either metabolic or signalling) through contradictory or reinforcing pathways. We highlight the complexity of the endocannabinoid system, based on the promiscuous nature of ECLs and their metabolites, as well as the synthetic modulators of the endocannabinoid system. British Journal of Pharmacology (2007) 152, 602–623; doi:10.1038/sj.bjp.0707456; published online 17 September 2007

Journal

British Journal of PharmacologyWiley

Published: Nov 1, 2007

References