INTRODUCTIONThere is a sustained interest in the use of saliva or oral fluid, as the body fluid for the diagnosis of oral as well as systemic diseases (Miller et al., ; Spielmann & Wong, ; Tabak, ; Zhang et al., ). Using saliva for the diagnosis of systemic diseases is feasible primarily because saliva contains a small amount of plasma (Oppenheim, ; Oppenheim & Hay, ). The detectability of plasma‐derived biomarkers in saliva facilitates not only the monitoring of disease processes restricted to the oral cavity but also of diseases manifested elsewhere in the human body (Kaufman & Lamster, ; Schafer et al., ). The major plasma components present in saliva are derived from gingival crevicular fluid (GCF), which enters the oral cavity through the gingival sulcus or a periodontal pocket, and to a much lesser extent through para‐cellular seepage from the vasculature of the salivary gland tissue (Kaufman & Lamster, ; Oppenheim, ; Oppenheim & Hay, ). Via the gingival sulcus, there is a direct connection with the circulation and this provides the unique opportunity to measure, in saliva, biomarkers for systemic disease.The plasma component in saliva is not the only fraction that contains biomarkers for systemic disease. Another source of
Oral Diseases – Wiley
Published: Jan 1, 2018
Keywords: ; ; ; ; ;
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