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Luca Crimaldi, S. Courtneidge, M. Gimona (2009)
Tks5 recruits AFAP-110, p190RhoGAP, and cortactin for podosome formation.Experimental cell research, 315 15
C. Sarmiento, Weigang Wang, Athanassios Dovas, H. Yamaguchi, M. Sidani, M. El-Sibai, Vera Desmarais, H. Holman, S. Kitchen, J. Backer, A. Alberts, J. Condeelis (2008)
WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cellsThe Journal of Cell Biology, 180
A. Gohla, J. Birkenfeld, G. Bokoch (2005)
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamicsNature Cell Biology, 7
L. Soon (2007)
A discourse on cancer cell chemotaxis: Where to from here?IUBMB Life, 59
M. Meira, R. Masson, I. Stagljar, S. Lienhard, Francisca Maurer, A. Boulay, N. Hynes (2009)
Memo is a cofilin-interacting protein that influences PLCγ1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migrationJournal of Cell Science, 122
V. Gorbatyuk, N. Nosworthy, S. Robson, N. Bains, M. Maciejewski, C. Remedios, G. King (2006)
Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction.Molecular cell, 24 4
H. Yamaguchi, M. Lorenz, S. Kempiak, C. Sarmiento, Salvatore Coniglio, M. Symons, J. Segall, R. Eddy, H. Miki, T. Takenawa, J. Condeelis (2005)
Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin
R. Plattner, B. Irvin, Shuling Guo, K. Blackburn, A. Kazlauskas, R. Abraham, J. York, A. Pendergast (2003)
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1Nature Cell Biology, 5
S. Matsui, R. Adachi, K. Kusui, T. Yamaguchi, T. Kasahara, T. Hayakawa, K. Suzuki (2001)
U73122 inhibits the dephosphorylation and translocation of cofilin in activated macrophage-like U937 cells.Cellular signalling, 13 1
Vera Desmarais, H. Yamaguchi, Matthew Oser, L. Soon, G. Mouneimne, C. Sarmiento, R. Eddy, J. Condeelis (2009)
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells.Cell motility and the cytoskeleton, 66 6
S. Tehrani, N. Tomašević, S. Weed, R. Sakowicz, J. Cooper (2007)
Src phosphorylation of cortactin enhances actin assemblyProceedings of the National Academy of Sciences, 104
Chunxiang Sun, M. Magalhaes, M. Glogauer (2007)
Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptorThe Journal of Cell Biology, 179
M. Ghosh, Xiaoyan Song, G. Mouneimne, M. Sidani, D. Lawrence, J. Condeelis (2004)
Cofilin Promotes Actin Polymerization and Defines the Direction of Cell MotilityScience, 304
M. Troys, L. Huyck, Shirley Leyman, S. Dhaese, J. Vandekerkhove, C. Ampe (2008)
Ins and outs of ADF/cofilin activity and regulation.European journal of cell biology, 87 8-9
T. Kanamori, T. Hayakawa, Masami Suzuki, K. Titani (1995)
Identification of Two 17-kDa Rat Parotid Gland Phosphoproteins, Subjects for Dephosphorylation upon β-Adrenergic Stimulation, as Destrin- and Cofilin-like Proteins (*)The Journal of Biological Chemistry, 270
M. Zoudilova, Puneet Kumar, Lan Ge, Ping Wang, G. Bokoch, K. DeFea (2007)
β-Arrestin-dependent Regulation of the Cofilin Pathway Downstream of Protease-activated Receptor-2*Journal of Biological Chemistry, 282
T. Eiseler, Heike Döppler, I. Yan, K. Kitatani, K. Mizuno, P. Storz (2009)
Protein Kinase D1 regulates Cofilin mediated F-actin reorganization and cell motility via SlingshotNature cell biology, 11
Nicole Bryce, E. Clark, Ja’Mes Leysath, Joshua Currie, D. Webb, Alissa Weaver (2005)
Cortactin Promotes Cell Motility by Enhancing Lamellipodial PersistenceCurrent Biology, 15
Stefanie Lapetina, C. Mader, K. Machida, B. Mayer, A. Koleske (2009)
Arg interacts with cortactin to promote adhesion-dependent cell edge protrusionThe Journal of Cell Biology, 185
N. Zebda, O. Bernard, M. Bailly, S. Welti, D. Lawrence, J. Condeelis (2000)
Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod ExtensionThe Journal of Cell Biology, 151
A. Kruchten, E. Krueger, Yu Wang, M. McNiven (2008)
Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions.American journal of physiology. Cell physiology, 295 5
Matthew Oser, H. Yamaguchi, H. Yamaguchi, C. Mader, J. Bravo-Cordero, Marianela Arias, Xiaoming Chen, Vera Desmarais, J. Rheenen, J. Rheenen, A. Koleske, J. Condeelis (2009)
Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturationThe Journal of Cell Biology, 186
T. Marshall, Heather Aloor, J. Bear (2009)
Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathwayJournal of Cell Science, 122
M. Zoudilova, Lan Ge, Puneet Kumar, G. Bokoch, K. DeFea (2007)
Beta‐arrestin‐dependent regulation of the cofilin pathway downstream of Protease‐activated receptor‐2The FASEB Journal, 21
J. Bamburg, O. Wiggan (2002)
ADF/cofilin and actin dynamics in disease.Trends in cell biology, 12 12
Weigang Wang, S. Goswami, K. Lapidus, Amber Wells, J. Wyckoff, E. Sahai, R. Singer, J. Segall, J. Condeelis (2004)
Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary TumorsCancer Research, 64
S. Ikeda, L. Cunningham, D. Boggess, N. Hawes, C. Hobson, J. Sundberg, J. Naggert, Richard Smith, P. Nishina (2003)
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor).Human molecular genetics, 12 9
J. Rheenen, J. Condeelis, M. Glogauer (2009)
A common cofilin activity cycle in invasive tumor cells and inflammatory cellsJournal of Cell Science, 122
M. Baldassarre, A. Pompeo, G. Beznoussenko, C. Castaldi, Salvatore Cortellino, M. McNiven, A. Luini, R. Buccione (2003)
Dynamin participates in focal extracellular matrix degradation by invasive cells.Molecular biology of the cell, 14 3
Weigang Wang, J. Wyckoff, S. Goswami, Yarong Wang, M. Sidani, J. Segall, J. Condeelis (2007)
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.Cancer research, 67 8
R. Bagheri-Yarmand, A. Mazumdar, A. Sahin, Rakesh Kumar (2006)
LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase‐type plasminogen activator systemInternational Journal of Cancer, 118
Weigang Wang, R. Eddy, J. Condeelis (2007)
The cofilin pathway in breast cancer invasion and metastasisNature Reviews Cancer, 7
Juliana Soosairajah, S. Maiti, O. Wiggan, P. Sarmiere, Nathalie Moussi, B. Sarcevic, R. Sampath, J. Bamburg, O. Bernard (2005)
Interplay between components of a novel LIM kinase–slingshot phosphatase complex regulates cofilinThe EMBO Journal, 24
Alissa Weaver, A. Karginov, Andrew Kinley, S. Weed, Yan Li, J. Parsons, J. Cooper (2001)
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formationCurrent Biology, 11
S. Stylli, S. I, A. Verhagen, San Xu, I. Pass, S. Courtneidge, P. Lock (2009)
Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradationJournal of Cell Science, 122
C. Frantz, G. Barreiro, L. Domínguez, Xiaoming Chen, R. Eddy, J. Condeelis, M. Kelly, M. Jacobson, D. Barber (2008)
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide bindingThe Journal of Cell Biology, 183
A. Ammer, S. Weed (2008)
Cortactin branches out: roles in regulating protrusive actin dynamics.Cell motility and the cytoskeleton, 65 9
H. Higgs (2005)
Formin proteins: a domain-based approach.Trends in biochemical sciences, 30 6
Vera Desmarais, F. Macaluso, J. Condeelis, M. Bailly (2004)
Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extensionJournal of Cell Science, 117
T. Kiuchi, K. Ohashi, Souichi Kurita, K. Mizuno (2007)
Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomersThe Journal of Cell Biology, 177
Chikio Chan, C. Beltzner, T. Pollard (2009)
Cofilin Dissociates Arp2/3 Complex and Branches from Actin FilamentsCurrent Biology, 19
I. Ichetovkin, Wayne Grant, J. Condeelis (2002)
Cofilin Produces Newly Polymerized Actin Filaments that Are Preferred for Dendritic Nucleation by the Arp2/3 ComplexCurrent Biology, 12
K. Moriyama, K. Iida, I. Yahara (1996)
Phosphorylation of Ser‐3 of cofilin regulates its essential function on actinGenes to Cells, 1
E. Andrianantoandro, T. Pollard (2006)
Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.Molecular cell, 24 1
M. Carlier, Valérie Laurent, J. Santolini, R. Melki, D. Didry, G. Xia, Yan Hong, N. Chua, D. Pantaloni (1997)
Actin Depolymerizing Factor (ADF/Cofilin) Enhances the Rate of Filament Turnover: Implication in Actin-based MotilityThe Journal of Cell Biology, 136
Kyoko Nagata-Ohashi, Yusaku Ohta, Kazumichi Goto, Shuhei Chiba, Reiko Mori, M. Nishita, K. Ohashi, Kazuyoshi Kousaka, A. Iwamatsu, R. Niwa, T. Uemura, K. Mizuno (2004)
A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodiaThe Journal of Cell Biology, 165
T. Pollard (2007)
Regulation of actin filament assembly by Arp2/3 complex and formins.Annual review of biophysics and biomolecular structure, 36
R. Scott, M. Olson (2007)
LIM kinases: function, regulation and association with human diseaseJournal of Molecular Medicine, 85
Weigang Wang, G. Mouneimne, M. Sidani, J. Wyckoff, Xiaoming Chen, A. Makris, S. Goswami, A. Bresnick, J. Condeelis (2006)
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumorsThe Journal of Cell Biology, 173
Tsukasa Oikawa, T. Itoh, T. Takenawa (2008)
Sequential signals toward podosome formation in NIH-src cellsThe Journal of Cell Biology, 182
C. Gurniak, E. Perlas, W. Witke (2005)
The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration.Developmental biology, 278 1
Timothy Huang, C. Dermardirossian, G. Bokoch (2006)
Cofilin phosphatases and regulation of actin dynamics.Current opinion in cell biology, 18 1
C. Abram, D. Seals, I. Pass, Daniel Salinsky, L. Maurer, Therese Roth, S. Courtneidge (2003)
The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells*The Journal of Biological Chemistry, 278
M. Sidani, D. Wessels, G. Mouneimne, M. Ghosh, S. Goswami, C. Sarmiento, Weigang Wang, S. Kuhl, M. El-Sibai, J. Backer, R. Eddy, D. Soll, J. Condeelis (2007)
Cofilin determines the migration behavior and turning frequency of metastatic cancer cellsThe Journal of Cell Biology, 179
A. Mogilner, G. Oster (2003)
Force generation by actin polymerization II: the elastic ratchet and tethered filaments.Biophysical journal, 84 3
A. Hosoda, N. Sato, R. Nagaoka, H. Abe, T. Obinata (2007)
Activity of cofilin can be regulated by a mechanism other than phosphorylation/dephosphorylation in muscle cells in cultureJournal of Muscle Research and Cell Motility, 28
Xiaoyan Song, Xiaoming Chen, H. Yamaguchi, G. Mouneimne, J. Condeelis, R. Eddy (2006)
Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cellsJournal of Cell Science, 119
Amanda Chan, M. Bailly, N. Zebda, J. Segall, J. Condeelis (2000)
Role of Cofilin in Epidermal Growth Factor–Stimulated Actin Polymerization and Lamellipod ProtrusionThe Journal of Cell Biology, 148
J. Rheenen, Xiaoyan Song, Wies Roosmalen, M. Cammer, Xiaoming Chen, Vera Desmarais, S. Yip, J. Backer, R. Eddy, J. Condeelis (2007)
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cellsThe Journal of Cell Biology, 179
I. Ichetovkin, Jinghua Han, Ka Pang, David Knecht, John Condeelis (2000)
Actin filaments are severed by both native and recombinant dictyostelium cofilin but to different extents.Cell motility and the cytoskeleton, 45 4
Q. Zhan, J. Bamburg, J. Badwey (2003)
Products of phosphoinositide specific phospholipase C can trigger dephosphorylation of cofilin in chemoattractant stimulated neutrophils.Cell motility and the cytoskeleton, 54 1
Ikeda (2003)
Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor)Hum Mol Genet, 12
G. Mouneimne, Vera Desmarais, M. Sidani, E. Scemes, Weigang Wang, Xiaoyan Song, R. Eddy, J. Condeelis (2006)
Spatial and Temporal Control of Cofilin Activity Is Required for Directional Sensing during ChemotaxisCurrent Biology, 16
Alissa Weaver (2008)
Cortactin in tumor invasiveness.Cancer letters, 265 2
G. Mouneimne, L. Soon, Vera Desmarais, M. Sidani, Xiaoyan Song, S. Yip, M. Ghosh, R. Eddy, J. Backer, J. Condeelis (2004)
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulationThe Journal of Cell Biology, 166
S. Arber, Freda Barbayannis, H. Hanser, C. Schneider, C. Stanyon, O. Bernard, P. Caroni (1998)
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinaseNature, 393
Pirta Hotulainen, E. Paunola, Maria Vartiainen, P. Lappalainen (2004)
Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.Molecular biology of the cell, 16 2
T. Eiseler, Heike Döppler, I. Yan, S. Goodison, P. Storz (2009)
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasionBreast Cancer Research : BCR, 11
Liang Cai, A. Makhov, D. Schafer, J. Bear (2008)
Coronin 1B Antagonizes Cortactin and Remodels Arp2/3-Containing Actin Branches in LamellipodiaCell, 134
Scott Boyle, G. Michaud, B. Schweitzer, P. Predki, A. Koleske (2007)
A Critical Role for Cortactin Phosphorylation by Abl-Family Kinases in PDGF-Induced Dorsal-Wave FormationCurrent Biology, 17
Vera Desmarais, M. Ghosh, R. Eddy, J. Condeelis (2005)
Cofilin takes the leadJournal of Cell Science, 118
Olivia Mooren, Tatyana Kotova, A. Moore, D. Schafer (2009)
Dynamin2 GTPase and Cortactin Remodel Actin Filaments*The Journal of Biological Chemistry, 284
Jianwei Zhu, Dan Yu, Xianchun Zeng, K. Zhou, X. Zhan (2007)
Receptor-mediated Endocytosis Involves Tyrosine Phosphorylation of Cortactin*Journal of Biological Chemistry, 282
Liang Cai, T. Marshall, A. Uetrecht, D. Schafer, J. Bear (2007)
Coronin 1B Coordinates Arp2/3 Complex and Cofilin Activities at the Leading EdgeCell, 128
P. Devreotes, C. Janetopoulos (2003)
Eukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization*Journal of Biological Chemistry, 278
The actin severing protein cofilin is essential for directed cell migration and chemotaxis, in many cell types and is also important for tumor cell invasion during metastasis. Through its severing activity, cofilin increases the number of free barbed ends to initiate actin polymerization for actin‐based protrusion in two distinct subcellular compartments in invasive tumor cells: lamellipodia and invadopodia. Cofilin severing activity is tightly regulated and multiple mechanisms are utilized to regulate cofilin activity. In this prospect, we have grouped the primary on/off regulation into two broad categories, both of which are important for inhibiting cofilin from binding to F‐actin or G‐actin: (1) Blocking cofilin activity by the binding of cofilin to either PI(4,5)P2 at lamellipodia, or cortactin at invadopodia. (2) Blocking cofilin's ability to bind to actin via serine phosphorylation. Although the literature suggests that these cofilin regulatory mechanisms may be cell‐type dependent, we propose the existence of a common cofilin activity cycle in which both operate. In this common cycle, the mechanism used to initiate cofilin activity is determined by the starting point in the cycle in a given subcellular compartment. J. Cell. Biochem. 108: 1252–1262, 2009. © 2009 Wiley‐Liss, Inc.
Journal of Cellular Biochemistry – Wiley
Published: Mar 15, 2010
Keywords: ; ; ; ;
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