To the Editor: In their letter in response to our review, Godeart and colleagues have underlined the way by which we have estimated the potential burden of Chikungunya virus (CHIKV) infection in older people. Evidence from epidemiological, clinical, and laboratory studies suggest an age‐related defect in the immune system inducing a state of susceptibility and vulnerability to new or emerging pathogens. With respect to arboviral diseases, in addition to infants, older adults are often the first affected with the highest incidence of severe and atypical cases. For example, in the first outbreak of West Nile Virus in the United States in 1999, the median age was 71, with 73% of those affected aged 60 and older. In 2000 in Israel, all of the victims were aged 78 and older. Similar trends can be drawn in the United States with California encephalitis, dengue, Eastern equine encephalitis, St. Louis encephalitis, yellow fever, and Zika, which are also spread by mosquitoes. For CHIKV, data are less abundant and conclusive. As detailed by Godeart and colleagues and in our review, the effect of the age‐associated remodeling of the immune system probably contributes to the highest incidence of atypical presentation at the acute stage
Journal of American Geriatrics Society – Wiley
Published: Jan 1, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera