Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Klann, J. Sweatt (2008)
Altered protein synthesis is a trigger for long-term memory formationNeurobiology of Learning and Memory, 89
J. Dompierre, J. Godin, Bénédicte Charrin, F. Cordelières, S. King, S. Humbert, F. Saudou (2007)
Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin AcetylationThe Journal of Neuroscience, 27
Kristian Hedstrom, Xiaorong Xu, Y. Ogawa, R. Frischknecht, C. Seidenbecher, P. Shrager, M. Rasband (2007)
Neurofascin assembles a specialized extracellular matrix at the axon initial segmentThe Journal of Cell Biology, 178
F. Yu, M. Mantegazza, R. Westenbroek, C. Robbins, F. Kalume, K. Burton, W. Spain, G. McKnight, T. Scheuer, W. Catterall (2007)
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancyNature Neuroscience, 10
Kristian Hedstrom, Y. Ogawa, M. Rasband (2008)
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarityThe Journal of Cell Biology, 183
H. Vacher, Jae-Won Yang, Oscar Cerda, A. Autillo‐Touati, B. Dargent, J. Trimmer (2011)
Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targetingThe Journal of Cell Biology, 192
Maarten Kole, Johannes Letzkus, G. Stuart (2007)
Axon Initial Segment Kv1 Channels Control Axonal Action Potential Waveform and Synaptic EfficacyNeuron, 55
Tamako Misawa, H. Mizusawa (2010)
[Anti-VGKC antibody-associated limbic encephalitis/Morvan syndrome].Brain and nerve = Shinkei kenkyu no shinpo, 62 4
L. Palmer, G. Stuart (2006)
Site of Action Potential Initiation in Layer 5 Pyramidal NeuronsThe Journal of Neuroscience, 26
Melinda Martin, Bin Tang, L. Papale, F. Yu, W. Catterall, A. Escayg (2007)
The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.Human molecular genetics, 16 23
I. Raman, L. Sprunger, M. Meisler, B. Bean (1997)
Altered Subthreshold Sodium Currents and Disrupted Firing Patterns in Purkinje Neurons of Scn8a Mutant MiceNeuron, 19
J. Luebke, Yu-Ming Chang, T. Moore, D. Rosene (2004)
Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortexNeuroscience, 125
D. Koticha, J. Babiarz, Noriko Kane-Goldsmith, J. Jacob, Karthik Raju, M. Grumet (2005)
Cell adhesion and neurite outgrowth are promoted by neurofascin NF155 and inhibited by NF186Molecular and Cellular Neuroscience, 30
A. Lorincz, Z. Nusser (2008)
Cell-Type-Dependent Molecular Composition of the Axon Initial SegmentThe Journal of Neuroscience, 28
J. DeFelipe, S. Hendry, Ani JONES, D. Schmechel, J. O'leary (1985)
Variability in the terminations of GABAergic chandelier cell axons on initial segments of pyramidal cell axons in the monkey sensory‐motor cortexJournal of Comparative Neurology, 231
Michel Royeck, M. Horstmann, S. Remy, M. Reitze, Yoel (2008)
Yaari and Heinz Beck
Baris Bingol, Morgan Sheng (2011)
Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and DiseaseNeuron, 69
I. Scheffer, L. Harkin, B. Grinton, L. Dibbens, S. Turner, M. Zielinski, R. Xu, G. Jackson, J. Adams, M. Connellan, S. Petrou, R. Wellard, R. Briellmann, R. Wallace, J. Mulley, S. Berkovic, I. Scheffer (2006)
Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations.Brain : a journal of neurology, 130 Pt 1
M. Grubb, J. Burrone (2010)
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitabilityNature, 465
Amanda Foust, Marko Popovic, D. Zecevic, D. McCormick (2010)
Action Potentials Initiate in the Axon Initial Segment and Propagate through Axon Collaterals Reliably in Cerebellar Purkinje NeuronsThe Journal of Neuroscience, 30
Nancy Osorio, L. Cathala, M. Meisler, M. Crest, J. Magistretti, P. Delmas (2010)
Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cellsThe Journal of Physiology, 588
Tünde Molnár, K. Antal, Gabriella Nyitrai, Z. Emri (2009)
γ-Hydroxybutyrate (GHB) induces GABAB receptor independent intracellular Ca2+ transients in astrocytes, but has no effect on GHB or GABAB receptors of medium spiny neurons in the nucleus accumbensNeuroscience, 162
B. Bakkaloglu, B. Bakkaloglu, B. O’Roak, A. Louvi, Abha Gupta, Jesse Abelson, T. Morgan, K. Chawarska, A. Klin, A. Ercan-Sencicek, Althea Stillman, G. Tanriover, B. Abrahams, J. Duvall, Elissa Robbins, D. Geschwind, T. Biederer, M. Gunel, R. Lifton, M. State (2008)
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.American journal of human genetics, 82 1
H. Lai, L. Jan (2006)
The distribution and targeting of neuronal voltage-gated ion channelsNature Reviews Neuroscience, 7
M. Grubb, J. Burrone (2010)
Building and maintaining the axon initial segmentCurrent Opinion in Neurobiology, 20
B. Bean (2007)
The action potential in mammalian central neuronsNature Reviews Neuroscience, 8
Lindsey Glickfeld, J. Roberts, P. Somogyi, M. Scanziani (2009)
Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axisNature Neuroscience, 12
C. Biervert, Björn Schroeder, C. Kubisch, S. Berkovic, P. Propping, T. Jentsch, O. Steinlein (1998)
A potassium channel mutation in neonatal human epilepsy.Science, 279 5349
V. Wimmer, C. Reid, S. Mitchell, K. Richards, Byron Scaf, B. Leaw, E. Hill, Michel Royeck, M. Horstmann, B. Cromer, P. Davies, R. Xu, H. Lerche, S. Berkovic, H. Beck, S. Petrou (2010)
Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.The Journal of clinical investigation, 120 8
Ashok Kumar, T. Foster (2007)
Neurophysiology of Old Neurons and Synapses
L. Meadows, J. Malhotra, Andrew Loukas, V. Thyagarajan, K. Kazen-Gillespie, Matthew Koopman, S. Kriegler, L. Isom, D. Ragsdale (2002)
Functional and Biochemical Analysis of a Sodium Channel β1 Subunit Mutation Responsible for Generalized Epilepsy with Febrile Seizures Plus Type 1The Journal of Neuroscience, 22
D. Sánchez-Ponce, A. Muñoz, J. Garrido (2011)
Casein kinase 2 and microtubules control axon initial segment formationMolecular and Cellular Neuroscience, 46
W. Catterall (1981)
Localization of sodium channels in cultured neural cells, 1
H. Kuba, Y. Oichi, H. Ohmori (2010)
Presynaptic activity regulates Na+ channel distribution at the axon initial segmentNature, 465
Nadine Burkarth, M. Kriebel, E. Kranz, H. Volkmer (2007)
Neurofascin regulates the formation of gephyrin clusters and their subsequent translocation to the axon hillock of hippocampal neuronsMolecular and Cellular Neuroscience, 36
B. Winckler, P. Forscher, I. Mellman (1999)
A diffusion barrier maintains distribution of membrane proteins in polarized neuronsNature, 397
Angela Cantrell, W. Catterall (2001)
Neuromodulation of Na+ channels: An unexpected form of cellular platicityNature Reviews Neuroscience, 2
J. Burbach, B. Zwaag (2009)
Contact in the genetics of autism and schizophreniaTrends in Neurosciences, 32
Michel Royeck, M. Horstmann, S. Remy, M. Reitze, Y. Yaari, H. Beck (2008)
Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.Journal of neurophysiology, 100 4
J. Malhotra, K. Kazen-Gillespie, M. Hortsch, L. Isom (2000)
Sodium Channel β Subunits Mediate Homophilic Cell Adhesion and Recruit Ankyrin to Points of Cell-Cell Contact*The Journal of Biological Chemistry, 275
Jürgen-Markus Sobotzik, J. Sie, C. Politi, D. Turco, V. Bennett, T. Deller, C. Schultz (2009)
AnkyrinG is required to maintain axo-dendritic polarity in vivoProceedings of the National Academy of Sciences, 106
Maarten Kole, G. Stuart (2008)
Is action potential threshold lowest in the axon?Nature Neuroscience, 11
M. Ferreira, M. O’Donovan, Y. Meng, I. Jones, D. Ruderfer, Lisa Jones, Jinbo Fan, G. Kirov, R. Perlis, E. Green, J. Smoller, D. Grozeva, J. Stone, I. Nikolov, K. Chambert, M. Hamshere, V. Nimgaonkar, V. Moskvina, M. Thase, S. Caesar, G. Sachs, J. Franklin, K. Gordon-Smith, K. Ardlie, S. Gabriel, C. Fraser, B. Blumenstiel, M. Defelice, G. Breen, M. Gill, D. Morris, A. Elkin, W. Muir, K. McGhee, R. Williamson, D. Macintyre, A. Maclean, D. Clair, M. Robinson, Margaret Beck, Ana Pereira, R. Kandaswamy, A. McQuillin, D. Collier, N. Bass, A. Young, J. Lawrence, I. Ferrier, A. Anjorin, A. Farmer, D. Curtis, E. Scolnick, P. McGuffin, M. Daly, A. Corvin, P. Holmans, D. Blackwood, H. Gurling, M. Owen, S. Purcell, P. Sklar, N. Craddock (2008)
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorderNature Genetics, 40
S. Raghavachari, M. Kahana, D. Rizzuto, J. Caplan, M. Kirschen, B. Bourgeois, J. Madsen, J. Lisman (2001)
Gating of Human Theta Oscillations by a Working Memory TaskThe Journal of Neuroscience, 21
J. Cornelius, S. Pittock, A. McKeon, V. Lennon, Paula Aston, K. Josephs, M. Tippmann-Peikert, M. Silber (2011)
Sleep manifestations of voltage-gated potassium channel complex autoimmunity.Archives of neurology, 68 6
F. Kalume, F. Yu, R. Westenbroek, T. Scheuer, W. Catterall (2007)
Reduced Sodium Current in Purkinje Neurons from NaV1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in InfancyThe Journal of Neuroscience, 27
Ichiro Sugiyama, Kayoko Tanaka, M. Akita, Kazunari Yoshida, T. Kawase, H. Asou (2002)
Ultrastructural analysis of the paranodal junction of myelinated fibers in 31‐month‐old‐ratsJournal of Neuroscience Research, 70
S. Waxman (2001)
Transcriptional channelopathies: An emerging class of disordersNature Reviews Neuroscience, 2
Maria Inda, J. DeFelipe, A. Muñoz (2006)
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells.Proceedings of the National Academy of Sciences of the United States of America, 103 8
Gustavo Patiño, L. Claes, L. Lopez-Santiago, E. Slat, Raja Dondeti, Chunling Chen, Heather O’Malley, Charles Gray, Haruko Miyazaki, N. Nukina, F. Oyama, P. Jonghe, L. Isom (2009)
A Functional Null Mutation of SCN1B in a Patient with Dravet SyndromeThe Journal of Neuroscience, 29
T. Nakata, N. Hirokawa (2003)
Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor headThe Journal of Cell Biology, 162
(2007)
Na(v)1.1 localizes to axons of parvalbumin
Audra Wart, G. Matthews (2006)
Expression of sodium channels Nav1.2 and Nav1.6 during postnatal development of the retinaNeuroscience Letters, 403
L. Altshuler, J. Ventura, W. Gorp, Michael Green, D. Théberge, J. Mintz (2004)
Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjectsBiological Psychiatry, 56
Sanchez‐Ponce Sanchez‐Ponce, Tapia Tapia, Munoz Munoz, Garrido Garrido (2008)
New role of IKK alpha/beta phosphorylated I kappa B alpha in axon outgrowth and axon initial segment developmentMol. Cell. Neurosci., 37
Audra Wart, G. Matthews (2006)
Impaired Firing and Cell-Specific Compensation in Neurons Lacking Nav1.6 Sodium ChannelsThe Journal of Neuroscience, 26
E. Bird, E. Spokes, J. Barnes, A. Mackay, L. Iversen, M. Shepherd (1978)
GLUTAMIC-ACID DECARBOXYLASE IN SCHIZOPHRENIAThe Lancet, 311
H. Brody (1970)
Structural Changes in the Aging Nervous System, 7
J. Offord, W. Catterall (1989)
Electrical activity, cAMP, and cytosolic calcium regulate mRNA encoding sodium channel α subunits in rat muscle cellsNeuron, 2
D. Browne, S. Gancher, J. Nutt, E. Brunt, Eric Smith, P. Kramer, M. Litt (1994)
Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1Nature Genetics, 8
A. Peters (1993)
The absence of significant neuronal loss from cerebral cortex with ageNeurobiology of Aging, 14
Z. Huang, G. Cristo, F. Ango (2007)
Development of GABA innervation in the cerebral and cerebellar corticesNature Reviews Neuroscience, 8
D. Schafer, S. Jha, Fudong Liu, T. Akella, L. McCullough, M. Rasband (2009)
Disruption of the Axon Initial Segment Cytoskeleton Is a New Mechanism for Neuronal InjuryThe Journal of Neuroscience, 29
D. Wollner, W. Catterall (1986)
Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells.Proceedings of the National Academy of Sciences of the United States of America, 83 21
Maarten Kole, S. Ilschner, B. Kampa, Stephen Williams, P. Ruben, G. Stuart (2008)
Action potential generation requires a high sodium channel density in the axon initial segmentNature Neuroscience, 11
T. Mashimo, I. Ohmori, M. Ouchida, Y. Ohno, Toshiko Tsurumi, T. Miki, M. Wakamori, Shizuka Ishihara, Takashi Yoshida, A. Takizawa, Megumi Kato, M. Hirabayashi, M. Sasa, Y. Mori, T. Serikawa (2010)
A Missense Mutation of the Gene Encoding Voltage-Dependent Sodium Channel (Nav1.1) Confers Susceptibility to Febrile Seizures in RatsThe Journal of Neuroscience, 30
J. Friedman, T. Vrijenhoek, S. Markx, I. Janssen, W. Vliet, B. Faas, N. Knoers, W. Cahn, R. Kahn, L. Edelmann, Kenneth Davis, J. Silverman, H. Brunner, A. Kessel, C. Wijmenga, R. Ophoff, J. Veltman (2008)
CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsyMolecular Psychiatry, 13
Yong Lu, P. Monsivais, B. Tempel, E. Rubel (2004)
Activity‐dependent regulation of the potassium channel subunits Kv1.1 and Kv3.1Journal of Comparative Neurology, 470
Xiu-yu Shi, S. Yasumoto, E. Nakagawa, T. Fukasawa, S. Uchiya, S. Hirose (2009)
Missense mutation of the sodium channel gene SCN2A causes Dravet syndromeBrain and Development, 31
G. Cristo, Caizhi Wu, Bidisha Chattopadhyaya, Bidisha Chattopadhyaya, F. Ango, G. Knott, E. Welker, K. Svoboda, Z. Huang (2004)
Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputsNature Neuroscience, 7
Amandine Duflocq, B. Bras, E. Bullier, F. Couraud, Marc Davenne (2008)
Nav1.1 is predominantly expressed in nodes of Ranvier and axon initial segmentsMolecular and Cellular Neuroscience, 39
M. Leppert, V. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y. Nakamura, J. Lalouel, Raymond White (1989)
Benign familial neonatal convulsions linked to genetic markers on chromosome 20Nature, 337
H. Williams, N. Craddock, G. Russo, M. Hamshere, V. Moskvina, S. Dwyer, Rhodri Smith, E. Green, D. Grozeva, P. Holmans, M. Owen, M. O’Donovan (2011)
Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.Human molecular genetics, 20 2
Alexis Hill, A. Nishino, K. Nakajo, G. Zhang, J. Fineman, M. Selzer, Y. Okamura, E. Cooper (2008)
Ion Channel Clustering at the Axon Initial Segment and Node of Ranvier Evolved Sequentially in Early ChordatesPLoS Genetics, 4
Tatiana Boiko, M. Rasband, S. Levinson, J. Caldwell, G. Mandel, J. Trimmer, G. Matthews (2001)
Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same AxonNeuron, 30
Yao-Ying Ma, Sandy Henley, Jeff Toll, J. Jentsch, C. Evans, M. Levine, C. Cepeda (2013)
Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbensASN NEURO, 5
Z. Nusser (2009)
Variability in the subcellular distribution of ion channels increases neuronal diversityTrends in Neurosciences, 32
J. Malhotra, K. Kazen-Gillespie, M. Hortsch, L. Isom (2000)
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact.The Journal of biological chemistry, 275 15
S. Palay, C. Sotelo, A. Peters, P. Orkand (1968)
THE AXON HILLOCK AND THE INITIAL SEGMENTThe Journal of Cell Biology, 38
Ai-hong Song, Dong Wang, Gang Chen, Yuju Li, Jianhong Luo, S. Duan, M. Poo (2009)
A Selective Filter for Cytoplasmic Transport at the Axon Initial SegmentCell, 136
E. Toescu, M. Vreugdenhil (2010)
Calcium and normal brain ageing.Cell calcium, 47 2
T. Bourgeron (2009)
A synaptic trek to autismCurrent Opinion in Neurobiology, 19
K. Strauss, E. Puffenberger, M. Huentelman, S. Gottlieb, S. Dobrin, J. Parod, D. Stephan, D. Morton (2006)
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2.The New England journal of medicine, 354 13
D. Choi (1996)
Ischemia-induced neuronal apoptosisCurrent Opinion in Neurobiology, 6
Yang Yang, Y. Ogawa, Kristian Hedstrom, M. Rasband (2007)
βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinGThe Journal of Cell Biology, 176
D. Guan, M. Higgs, Leslie Horton, William Spain, R. Foehring (2011)
Contributions of Kv7-mediated potassium current to sub- and suprathreshold responses of rat layer II/III neocortical pyramidal neurons.Journal of neurophysiology, 106 4
C. Lewis, D. Faber (1993)
GABA responses and their partial occlusion by glycine in cultured rat medullary neuronsNeuroscience, 52
A. Vallely, A. Page, S. Dias, P. Siba, T. Lupiwa, G. Law, J. Millan, D. Wilson, J. Murray, M. Toole, J. Kaldor (2010)
The Prevalence of Sexually Transmitted Infections in Papua New Guinea: A Systematic Review and Meta-AnalysisPLoS ONE, 5
D. Sánchez-Ponce, Mónica Tapia, Alberto Muñoz, J. Garrido (2008)
New role of IKKα/β phosphorylated IκBα in axon outgrowth and axon initial segment developmentMolecular and Cellular Neuroscience, 37
A. Fairén, F. Valverde (1980)
A specialized type of neuron in the visual cortex of cat: A Golgi and electron microscope study of chandelier cellsJournal of Comparative Neurology, 194
W. Brackenbury, Jeffrey Calhoun, Chunling Chen, Haruko Miyazaki, N. Nukina, F. Oyama, B. Ranscht, L. Isom (2010)
Functional reciprocity between Na+ channel Nav1.6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowthProceedings of the National Academy of Sciences, 107
Gustavo Patiño, L. Isom (2010)
Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and diseaseNeuroscience Letters, 486
I. Horresh, S. Poliak, S. Grant, D. Bredt, M. Rasband, E. Peles (2008)
Multiple Molecular Interactions Determine the Clustering of Caspr2 and Kv1 Channels in Myelinated AxonsThe Journal of Neuroscience, 28
Wenqin Hu, Cuiping Tian, Tun Li, Mingpo Yang, Han Hou, Yousheng Shu (2009)
Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagationNature Neuroscience, 12
A. Peters (2002)
Structural changes that occur during normal aging of primate cerebral hemispheresNeuroscience & Biobehavioral Reviews, 26
B. Zonta, A. Desmazières, A. Rinaldi, Steven Tait, D. Sherman, M. Nolan, P. Brophy (2011)
A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial SegmentNeuron, 69
E. Mathey, T. Derfuss, M. Storch, Kieran Williams, K. Hales, David Woolley, A. Al-Hayani, S. Davies, M. Rasband, T. Olsson, A. Moldenhauer, S. Velhin, R. Hohlfeld, E. Meinl, C. Linington (2007)
Neurofascin as a novel target for autoantibody-mediated axonal injuryThe Journal of Experimental Medicine, 204
Silverman Wa (1980)
Non-treatment of defective newborn babies.Lancet, 2 8152
H. Vacher, Jae-Won Yang, Oscar Cerda, A. Autillo‐Touati, B. Dargent, J. Trimmer (2011)
Cdk-mediated phosphorylation of the Kvb2 auxiliary subunit regulates Kv1 channel axonal targetingThe Journal of General Physiology, 137
B. Boda, A. Dubos, D. Muller (2010)
Signaling mechanisms regulating synapse formation and function in mental retardationCurrent Opinion in Neurobiology, 20
Woodruff Woodruff, Xu Xu, Anderson Anderson, Yuste Yuste (2009)
Depolarizing effect of neocortical chandelier neuronsFront Neural Circuits, 3
Je-Hyun Baek, Oscar Cerda, J. Trimmer (2011)
Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels.Seminars in cell & developmental biology, 22 2
Y. Konishi, M. Setou (2009)
Tubulin tyrosination navigates the kinesin-1 motor domain to axonsNature Neuroscience, 12
C. Charlier, Nanda Singh, S. Ryan, T. Lewis, B. Reus, R. Leach, M. Leppert (1998)
A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy familyNature Genetics, 18
L. Isom, K. Jongh, D. Patton, B. Reber, B. Reber, J. Offord, J. Offord, H. Charbonneau, H. Charbonneau, K. Walsh, A. Goldin, W. Catterall (1992)
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.Science, 256 5058
Z. Pan, Tingching Kao, Z. Horváth, Julia Lemos, J. Sul, S. Cranstoun, V. Bennett, S. Scherer, E. Cooper (2006)
A Common Ankyrin-G-Based Mechanism Retains KCNQ and NaV Channels at Electrically Active Domains of the AxonThe Journal of Neuroscience, 26
A. Lorincz, Z. Nusser (2010)
Molecular Identity of Dendritic Voltage-Gated Sodium ChannelsScience, 328
Y. Kawaguchi, Jeffrey Kovacs, A. McLaurin, J. Vance, A. Ito, T. Yao (2003)
The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein StressCell, 115
(2008)
New role of IKK alpha ⁄ beta phosphorylated I kappa B alpha in axon outgrowth and axon
Guy Lemaillet, Barbara Walker, S. Lambert (2003)
Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits*Journal of Biological Chemistry, 278
M. Shah, M. Migliore, Ignacio Valencia, E. Cooper, D. Brown (2008)
Functional significance of axonal Kv7 channels in hippocampal pyramidal neuronsProceedings of the National Academy of Sciences, 105
D. Lewis (2011)
The chandelier neuron in schizophreniaDevelopmental Neurobiology, 71
P. Reddy, T. Reddy (2011)
Mitochondria as a therapeutic target for aging and neurodegenerative diseases.Current Alzheimer research, 8 4
J. Oakley, F. Kalume, W. Catterall (2011)
Insights into pathophysiology and therapy from a mouse model of Dravet syndromeEpilepsia, 52
D. Arking, D. Cutler, Camille Brune, Tanya Teslovich, K. West, Morna Ikeda, A. Rea, Moltu Guy, Shin Lin, E. Cook, A. Chakravarti (2008)
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism.American journal of human genetics, 82 1
Aline Bréchet, M. Fache, A. Brachet, G. Ferracci, A. Baude, M. Irondelle, Sandrine Pereira, Christophe Leterrier, B. Dargent (2008)
Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin GThe Journal of Cell Biology, 183
J. Sloane, J. Hinman, M. Lubonia, W. Hollander, C. Abraham (2002)
Age‐dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain‐1 in the rhesus monkeyJournal of Neurochemistry, 84
Guo-Yong Wang, G. Ratto, Silvia Bisti, L. Chalupa (1997)
Functional development of intrinsic properties in ganglion cells of the mammalian retina.Journal of neurophysiology, 78 6
K. Mossman (2008)
The Wellcome Trust Case Control Consortium, U.K.Scientific American, 298
M. Craner, J. Newcombe, J. Black, C. Hartle, M. Cuzner, S. Waxman (2004)
Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.Proceedings of the National Academy of Sciences of the United States of America, 101 21
E. Rossi, A. Verri, M. Patricelli, V. Destefani, I. Ricca, A. Vetro, R. Ciccone, R. Giorda, D. Toniolo, P. Maraschio, O. Zuffardi (2008)
A 12Mb deletion at 7q33-q35 associated with autism spectrum disorders and primary amenorrhea.European journal of medical genetics, 51 6
J. Hinman, A. Peters, H. Cabral, D. Rosene, W. Hollander, M. Rasband, C. Abraham (2006)
Age‐related molecular reorganization at the node of RanvierJournal of Comparative Neurology, 495
G. Turrigiano, S. Nelson (2004)
Homeostatic plasticity in the developing nervous systemNature Reviews Neuroscience, 5
Tatiana Boiko, Audra Wart, J. Caldwell, S. Levinson, J. Trimmer, G. Matthews (2003)
Functional Specialization of the Axon Initial Segment by Isoform-Specific Sodium Channel TargetingThe Journal of Neuroscience, 23
D. Volk, J. Pierri, J. Fritschy, S. Auh, A. Sampson, D. Lewis (2002)
Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia.Cerebral cortex, 12 10
S. Waxman, S. Dib-Hajj, T. Cummins, J. Black (2000)
Sodium channels and their genes: dynamic expression in the normal nervous system, dysregulation in disease states 1 1 Published on the World Wide Web on 15 August 2000.Brain Research, 886
C. Colbert, D. Johnston (1996)
Axonal Action-Potential Initiation and Na+ Channel Densities in the Soma and Axon Initial Segment of Subicular Pyramidal NeuronsThe Journal of Neuroscience, 16
R. Balaban, S. Nemoto, T. Finkel (2005)
Mitochondria, Oxidants, and AgingCell, 120
S. Poliak, D. Salomon, Hadas Elhanany, H. Sabanay, Brent Kiernan, L. Pevny, C. Stewart, Xiaorong Xu, S. Chiu, P. Shrager, A. Furley, E. Peles (2003)
Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1The Journal of Cell Biology, 162
D. Wallace, S. Melov (1998)
Radicals r'agingNature Genetics, 19
Jennifer Stone, M. O’Donovan, H. Gurling, G. Kirov, Douglas Blackwood, A. Corvin, N. Craddock, M. Gill, C. Hultman, Paul Lichtenstein, A. McQuillin, C. Pato, D. Ruderfer, M. Owen, D. Clair, Patrick Sullivan, P. Sklar, S. Purcell, Joshua Korn, Stuart Macgregor, Derek Morris, C. O’Dushlaine, Mark Daly, P. Visscher, P. Holmans, E. Scolnick, Nigel Williams, Lucy Georgieva, I. Nikolov, Nadine Norton, H. Williams, D. Toncheva, V. Milanova, E. Thelander, Patrick Sullivan, E. Kenny, J. Waddington, K. Choudhury, S. Datta, J. Pimm, S. Thirumalai, V. Puri, R. Krasucki, J. Lawrence, D. Quested, N. Bass, David Curtis, C. Crombie, Gillian Fraser, Soh Kwan, N. Walker, Walter Muir, K. McGhee, Ben Pickard, P. Malloy, A. Maclean, Margaret Beck, M. Pato, H. Medeiros, Frank Middleton, C. Carvalho, C. Morley, A. Fanous, David Conti, J. Knowles, C. Ferreira, A. Macedo, M. Azevedo, S. McCarroll, K. Chambert, Casey Gates, S. Gabriel, Scott Mahon, Kristen Ardlie (2008)
Rare chromosomal deletions and duplications increase risk of schizophreniaNature, 455
Nanda Singh, C. Charlier, D. Stauffer, B. Dupont, R. Leach, R. Melis, G. Ronen, I. Bjerre, T. Quattlebaum, Jerome Murphy, Malcolm McHarg, D. Gagnon, T. Rosales, A. Peiffer, V. Anderson, M. Leppert (1998)
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newbornsNature Genetics, 18
I. Fleidervish, N. Lasser‐Ross, M. Gutnick, W. Ross (2010)
Na+ imaging reveals little difference in action potential–evoked Na+ influx between axon and somaNature Neuroscience, 13
I. Ogiwara, H. Miyamoto, N. Morita, N. Atapour, E. Mazaki, I. Inoue, T. Takeuchi, S. Itohara, Y. Yanagawa, K. Obata, T. Furuichi, T. Hensch, K. Yamakawa (2007)
Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene MutationThe Journal of Neuroscience, 27
Stanislav Khirug, J. Yamada, R. Afzalov, J. Voipio, L. Khiroug, K. Kaila (2008)
GABAergic Depolarization of the Axon Initial Segment in Cortical Principal Neurons Is Caused by the Na–K–2Cl Cotransporter NKCC1The Journal of Neuroscience, 28
Frontiers in Neural Circuits Neural Circuits
V. Wimmer, C. Reid, Eva So, S. Berkovic, S. Petrou (2010)
Axon initial segment dysfunction in epilepsyThe Journal of Physiology, 588
H. Blumenfeld, A. Lampert, J. Klein, J. Mission, Michael Chen, Maritza Rivera, S. Dib-Hajj, Avis Brennan, B. Hains, S. Waxman (2009)
Role of hippocampal sodium channel Nav1.6 in kindling epileptogenesisEpilepsia, 50
Daixing Zhou, S. Lambert, P. Malen, Scott Carpenter, L. Boland, V. Bennett (1998)
AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential FiringThe Journal of Cell Biology, 143
S. Fried, Aaron Lasker, N. Desai, D. Eddington, J. Rizzo (2009)
Axonal sodium-channel bands shape the response to electric stimulation in retinal ganglion cells.Journal of neurophysiology, 101 4
M. Simpson, P. Slater, J. Deakin, M. Royston, W. Skan (1989)
Reduced GABA uptake sites in the temporal lobe in schizophreniaNeuroscience Letters, 107
Y. Ogawa, I. Horresh, J. Trimmer, D. Bredt, E. Peles, M. Rasband (2008)
Postsynaptic Density-93 Clusters Kv1 Channels at Axon Initial Segments Independently of Caspr2The Journal of Neuroscience, 28
Jared Snellenberg, I. Torres, A. Thornton (2006)
Functional neuroimaging of working memory in schizophrenia: task performance as a moderating variable.Neuropsychology, 20 5
Marko Popovic, Amanda Foust, D. McCormick, D. Zecevic (2011)
The spatio‐temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging studyThe Journal of Physiology, 589
J. Coombs, D. Curtis, J. Eccles (1957)
The generation of impulses in motoneuronesThe Journal of Physiology, 139
(2011)
Rasband a 2011 The Authors
J. Atherton, D. Wokosin, S. Ramanathan, M. Bevan (2008)
Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleusThe Journal of Physiology, 586
Xiao-Jing Wang (2010)
Neurophysiological and computational principles of cortical rhythms in cognition.Physiological reviews, 90 3
D. Koren, L. Seidman, W. Kremen, S. Faraone, J. Goldstein, M. Tsuang (2000)
A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychosesSchizophrenia Research, 41
Guiping Du, Xiang Liu, Xinping Chen, Mei Song, Yan Yan, R. Jiao, Chih-chen Wang (2010)
Drosophila Histone Deacetylase 6 Protects Dopaminergic Neurons against α-Synuclein Toxicity by Promoting Inclusion FormationMolecular Biology of the Cell, 21
T. Schulze, S. Detera-Wadleigh, N. Akula, A. Gupta, L. Kassem, Jo Steele, J. Pearl, J. Strohmaier, R. Breuer, M. Schwarz, P. Propping, M. Nöthen, S. Cichon, J. Schumacher, J. Schumacher, M. Rietschel, F. McMahon (2008)
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorderMolecular psychiatry, 14
H. Kuba, T. Ishii, H. Ohmori (2006)
Axonal site of spike initiation enhances auditory coincidence detectionNature, 444
A. Peters, C. Sethares, J. Luebke (2008)
Synapses are lost during aging in the primate prefrontal cortexNeuroscience, 152
T. Klassen, Caleb Davis, A. Goldman, D. Burgess, Tim Chen, D. Wheeler, J. McPherson, Traci Bourquin, L. Lewis, D. Villasana, M. Morgan, D. Muzny, R. Gibbs, J. Noebels (2011)
Exome Sequencing of Ion Channel Genes Reveals Complex Profiles Confounding Personal Risk Assessment in EpilepsyCell, 145
A. Iwata, B. Riley, J. Johnston, R. Kopito (2005)
HDAC6 and Microtubules Are Required for Autophagic Degradation of Aggregated Huntingtin*Journal of Biological Chemistry, 280
R. Siman, M. Baudry, G. Lynch (1984)
Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.Proceedings of the National Academy of Sciences of the United States of America, 81 11
R. Wallace, Daowen Wang, Rita Singh, I. Scheffer, A. George, H. Phillips, K. Saar, A. Reis, Eric Johnson, G. Sutherland, S. Berkovic, J. Mulley (1998)
Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel ß1 subunit gene SCN1BNature Genetics, 19
J. Szabadics, Csaba Varga, G. Molnár, Szabolcs Oláh, P. Barzó, G. Tamás (2006)
Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical MicrocircuitsScience, 311
Z. Mainen, J. Joerges, J. Huguenard, T. Sejnowski (1995)
A model of spike initiation in neocortical pyramidal neuronsNeuron, 15
J. Hinman, J. Duce, R. Siman, W. Hollander, C. Abraham (2004)
Activation of calpain‐1 in myelin and microglia in the white matter of the aged rhesus monkeyJournal of Neurochemistry, 89
D. Lewis, T. Hashimoto, D. Volk (2005)
Cortical inhibitory neurons and schizophreniaNature Reviews Neuroscience, 6
J. Garrido, P. Giraud, E. Carlier, Fanny Fernandes, Anissa Moussif, M. Fache, D. Debanne, B. Dargent (2003)
A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial SegmentScience, 300
D. Cruz, Cassandra Weaver, Emily Lovallo, D. Melchitzky, D. Lewis (2009)
Selective Alterations in Postsynaptic Markers of Chandelier Cell Inputs to Cortical Pyramidal Neurons in Subjects with SchizophreniaNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34
H. Kasai, M. Fukuda, Satoshi Watanabe, Akiko Hayashi-Takagi, J. Noguchi (2010)
Structural dynamics of dendritic spines in memory and cognitionTrends in Neurosciences, 33
G. Stuart, B. Sakmann (1994)
Active propagation of somatic action potentials into neocortical pyramidal cell dendritesNature, 367
L. Athanasiu, M. Mattingsdal, A. Kähler, A. Brown, Ó. Gústafsson, I. Agartz, I. Giegling, P. Muglia, S. Cichon, M. Rietschel, O. Pietiläinen, L. Peltonen, E. Bramon, D. Collier, D. Clair, E. Sigurdsson, H. Pétursson, D. Rujescu, I. Melle, V. Steen, S. Djurovic, O. Andreassen (2010)
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.Journal of psychiatric research, 44 12
B. Abrahams, D. Tentler, Julia Perederiy, Michael Oldham, G. Coppola, D. Geschwind (2007)
Genome-wide analyses of human perisylvian cerebral cortical patterningProceedings of the National Academy of Sciences, 104
S. Jenkins, V. Bennett (2001)
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segmentsThe Journal of Cell Biology, 155
Y. Ogawa, J. Oses-Prieto, M. Kim, I. Horresh, E. Peles, A. Burlingame, J. Trimmer, D. Meijer, M. Rasband (2010)
ADAM22, A Kv1 Channel-Interacting Protein, Recruits Membrane-Associated Guanylate Kinases to Juxtaparanodes of Myelinated AxonsThe Journal of Neuroscience, 30
M. Alarcón, B. Abrahams, J. Stone, J. Duvall, Julia Perederiy, J. Bomar, J. Sebat, M. Wigler, C. Martin, D. Ledbetter, S. Nelson, R. Cantor, D. Geschwind (2008)
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.American journal of human genetics, 82 1
Zayd Khaliq, I. Raman (2006)
Relative Contributions of Axonal and Somatic Na Channels to Action Potential Initiation in Cerebellar Purkinje NeuronsThe Journal of Neuroscience, 26
Nanda Singh, P. Westenskow, C. Charlier, C. Pappas, Jonathan Leslie, Jessica Dillon, V. Anderson, M. Sanguinetti, M. Leppert (2003)
KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.Brain : a journal of neurology, 126 Pt 12
Mónica Tapia, F. Wandosell, J. Garrido (2010)
Impaired Function of HDAC6 Slows Down Axonal Growth and Interferes with Axon Initial Segment DevelopmentPLoS ONE, 5
M. Rasband (2010)
The axon initial segment and the maintenance of neuronal polarityNature Reviews Neuroscience, 11
M. Rasband, T. Kagawa, Eunice Park, K. Ikenaka, J. Trimmer (2003)
Dysregulation of axonal sodium channel isoforms after adult‐onset chronic demyelinationJournal of Neuroscience Research, 73
F. Ango, G. Cristo, H. Higashiyama, V. Bennett, Priscilla Wu, Z.Josh Huang (2004)
Ankyrin-Based Subcellular Gradient of Neurofascin, an Immunoglobulin Family Protein, Directs GABAergic Innervation at Purkinje Axon Initial SegmentCell, 119
The axon initial segment (AIS), with its dense clusters of voltage‐gated ion channels decorating the axonal membrane, regulates action potential initiation and modulation. The AIS also functions as a barrier to maintain axodendritic polarity, and its precise axonal location contributes to the fine‐tuning of neuronal excitability. Therefore, it is not surprising that mutations in AIS‐related genes, disruption of the molecular organization of the AIS and altered AIS ion channel expression, function, location and/or density are emerging as key players in neurological disorders. Here, we consider the role of the AIS in nervous system disease and injury.
European Journal of Neuroscience – Wiley
Published: Nov 1, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.