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The axon initial segment in nervous system disease and injury

The axon initial segment in nervous system disease and injury The axon initial segment (AIS), with its dense clusters of voltage‐gated ion channels decorating the axonal membrane, regulates action potential initiation and modulation. The AIS also functions as a barrier to maintain axodendritic polarity, and its precise axonal location contributes to the fine‐tuning of neuronal excitability. Therefore, it is not surprising that mutations in AIS‐related genes, disruption of the molecular organization of the AIS and altered AIS ion channel expression, function, location and/or density are emerging as key players in neurological disorders. Here, we consider the role of the AIS in nervous system disease and injury. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Neuroscience Wiley

The axon initial segment in nervous system disease and injury

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References (176)

Publisher
Wiley
Copyright
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd
ISSN
0953-816X
eISSN
1460-9568
DOI
10.1111/j.1460-9568.2011.07875.x
pmid
22103418
Publisher site
See Article on Publisher Site

Abstract

The axon initial segment (AIS), with its dense clusters of voltage‐gated ion channels decorating the axonal membrane, regulates action potential initiation and modulation. The AIS also functions as a barrier to maintain axodendritic polarity, and its precise axonal location contributes to the fine‐tuning of neuronal excitability. Therefore, it is not surprising that mutations in AIS‐related genes, disruption of the molecular organization of the AIS and altered AIS ion channel expression, function, location and/or density are emerging as key players in neurological disorders. Here, we consider the role of the AIS in nervous system disease and injury.

Journal

European Journal of NeuroscienceWiley

Published: Nov 1, 2011

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