AbbreviationsAQamodiaquineCCcell controlCCIDcell culture infective doseCCZchlorcyclizineCPEcytopathic effectCQchloroquineDENVdengue virusDMEMDulbecco's minimal essential mediumDMSOdimethyl sulfoxide;EBOVEbola virusFBSfetal bovine serumHIVhuman immunodeficiency virusMOImultiplicity of infectionMPAmycophenolic acidMTS(3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazoliumMTT3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromidePBSphosphate‐buffered salinePCZprochlorperazine dimaleate saltPFUplaque forming unitsPIpostinfectionQDHquinacrine dihydrochlorideSDstandard deviationSIselection indexTOAtime‐of‐additionVCvirus controlZIKVZika virusINTRODUCTIONZika virus (ZIKV), belonging to the family of Flaviviridae, was first isolated from a monkey in Uganda in 1947. Since then, ZIKV has caused sporadic febrile illness with mild symptoms similar to that of dengue virus (DENV). Recent outbreaks of disease caused by ZIKV were reported in Brazil in May 2015, and the virus has now spread to 68 countries and territories as of December 2016, mostly in tropical and subtropical regions across the Caribbean, Latin America, and Asia. ZIKV is a mosquito‐borne virus that causes symptoms such as mild fever, skin rashes, headache, and joint pains. Additionally, recent studies have shown conclusive links between ZIKV and two serious conditions: microcephaly in newborns and neurological disorders such as Guillain‐Barré syndrome in adults. Currently there is no antiviral or vaccine available. Because of the threat to public health worldwide, the World Health Organization (WHO) declared a global emergency in February 2016. Thus, there is an urgent need to discover and develop effective anti‐ZIKV drugs and vaccines as soon as possible.To rapidly
Journal of Medical Virology – Wiley
Published: Jan 1, 2018
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