The antimalarial drug amodiaquine possesses anti‐ZIKA virus activities

The antimalarial drug amodiaquine possesses anti‐ZIKA virus activities AbbreviationsAQamodiaquineCCcell controlCCIDcell culture infective doseCCZchlorcyclizineCPEcytopathic effectCQchloroquineDENVdengue virusDMEMDulbecco's minimal essential mediumDMSOdimethyl sulfoxide;EBOVEbola virusFBSfetal bovine serumHIVhuman immunodeficiency virusMOImultiplicity of infectionMPAmycophenolic acidMTS(3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazoliumMTT3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromidePBSphosphate‐buffered salinePCZprochlorperazine dimaleate saltPFUplaque forming unitsPIpostinfectionQDHquinacrine dihydrochlorideSDstandard deviationSIselection indexTOAtime‐of‐additionVCvirus controlZIKVZika virusINTRODUCTIONZika virus (ZIKV), belonging to the family of Flaviviridae, was first isolated from a monkey in Uganda in 1947. Since then, ZIKV has caused sporadic febrile illness with mild symptoms similar to that of dengue virus (DENV). Recent outbreaks of disease caused by ZIKV were reported in Brazil in May 2015, and the virus has now spread to 68 countries and territories as of December 2016, mostly in tropical and subtropical regions across the Caribbean, Latin America, and Asia. ZIKV is a mosquito‐borne virus that causes symptoms such as mild fever, skin rashes, headache, and joint pains. Additionally, recent studies have shown conclusive links between ZIKV and two serious conditions: microcephaly in newborns and neurological disorders such as Guillain‐Barré syndrome in adults. Currently there is no antiviral or vaccine available. Because of the threat to public health worldwide, the World Health Organization (WHO) declared a global emergency in February 2016. Thus, there is an urgent need to discover and develop effective anti‐ZIKV drugs and vaccines as soon as possible.To rapidly http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Virology Wiley

The antimalarial drug amodiaquine possesses anti‐ZIKA virus activities

Loading next page...
 
/lp/wiley/the-antimalarial-drug-amodiaquine-possesses-anti-zika-virus-activities-ZZ0QS0yEx7
Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0146-6615
eISSN
1096-9071
D.O.I.
10.1002/jmv.25031
Publisher site
See Article on Publisher Site

Abstract

AbbreviationsAQamodiaquineCCcell controlCCIDcell culture infective doseCCZchlorcyclizineCPEcytopathic effectCQchloroquineDENVdengue virusDMEMDulbecco's minimal essential mediumDMSOdimethyl sulfoxide;EBOVEbola virusFBSfetal bovine serumHIVhuman immunodeficiency virusMOImultiplicity of infectionMPAmycophenolic acidMTS(3‐(4,5‐dimethylthiazol‐2‐yl)‐5‐(3‐carboxymethoxyphenyl)‐2‐(4‐sulfophenyl)‐2H‐tetrazoliumMTT3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromidePBSphosphate‐buffered salinePCZprochlorperazine dimaleate saltPFUplaque forming unitsPIpostinfectionQDHquinacrine dihydrochlorideSDstandard deviationSIselection indexTOAtime‐of‐additionVCvirus controlZIKVZika virusINTRODUCTIONZika virus (ZIKV), belonging to the family of Flaviviridae, was first isolated from a monkey in Uganda in 1947. Since then, ZIKV has caused sporadic febrile illness with mild symptoms similar to that of dengue virus (DENV). Recent outbreaks of disease caused by ZIKV were reported in Brazil in May 2015, and the virus has now spread to 68 countries and territories as of December 2016, mostly in tropical and subtropical regions across the Caribbean, Latin America, and Asia. ZIKV is a mosquito‐borne virus that causes symptoms such as mild fever, skin rashes, headache, and joint pains. Additionally, recent studies have shown conclusive links between ZIKV and two serious conditions: microcephaly in newborns and neurological disorders such as Guillain‐Barré syndrome in adults. Currently there is no antiviral or vaccine available. Because of the threat to public health worldwide, the World Health Organization (WHO) declared a global emergency in February 2016. Thus, there is an urgent need to discover and develop effective anti‐ZIKV drugs and vaccines as soon as possible.To rapidly

Journal

Journal of Medical VirologyWiley

Published: Jan 1, 2018

Keywords: ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off