The adenosine A2A receptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice

The adenosine A2A receptor agonist, CGS 21680, attenuates a probabilistic reversal learning... IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by the expression of social communication deficits and repetitive behaviors with restricted interests (RRBs) [Masi, DeMayo, Glozier, & Guastella, ]. RRBs include stereotyped movements and an insistence on sameness to a rule [Goldman et al., ; Lam & Aman, ]. Insistence on sameness can manifest as an inability to modulate action or thought patterns based on situational demands and is often described as behavioral inflexibility [Geurts, Corbett, & Solomon, ]. Presently, there are no FDA‐approved treatments for RRBs. This is particularly troubling because RRBs can be the most distressing feature of ASD to family members [Bishop, Richler, Cain, & Lord, ].A better understanding of the neuropathophysiology of RRBs can give insight into the development for effective treatments. Several studies indicate that alterations in cortico‐striatal‐thalamic‐cortical activity are related to RRBs [D'Cruz, Mosconi, Ragozzino, Cook, & Sweeney, ; Delmonte, Gallagher, O'hanlon, McGrath, & Balsters, ; Schuetze et al., ]. Other findings indicate that either striatal volume [Hollander et al., ] and striatal growth rate [Langen et al., ] in ASD are correlated with RRB severity. Preclinical experiments have identified specific striatal circuits that are dysregulated and may contribute to various RRBs. Direct http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

The adenosine A2A receptor agonist, CGS 21680, attenuates a probabilistic reversal learning deficit and elevated grooming behavior in BTBR mice

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
D.O.I.
10.1002/aur.1901
Publisher site
See Article on Publisher Site

Abstract

IntroductionAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by the expression of social communication deficits and repetitive behaviors with restricted interests (RRBs) [Masi, DeMayo, Glozier, & Guastella, ]. RRBs include stereotyped movements and an insistence on sameness to a rule [Goldman et al., ; Lam & Aman, ]. Insistence on sameness can manifest as an inability to modulate action or thought patterns based on situational demands and is often described as behavioral inflexibility [Geurts, Corbett, & Solomon, ]. Presently, there are no FDA‐approved treatments for RRBs. This is particularly troubling because RRBs can be the most distressing feature of ASD to family members [Bishop, Richler, Cain, & Lord, ].A better understanding of the neuropathophysiology of RRBs can give insight into the development for effective treatments. Several studies indicate that alterations in cortico‐striatal‐thalamic‐cortical activity are related to RRBs [D'Cruz, Mosconi, Ragozzino, Cook, & Sweeney, ; Delmonte, Gallagher, O'hanlon, McGrath, & Balsters, ; Schuetze et al., ]. Other findings indicate that either striatal volume [Hollander et al., ] and striatal growth rate [Langen et al., ] in ASD are correlated with RRB severity. Preclinical experiments have identified specific striatal circuits that are dysregulated and may contribute to various RRBs. Direct

Journal

Autism ResearchWiley

Published: Jan 1, 2018

Keywords: ; ; ; ;

References

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