Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis

Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis INTRODUCTIONHead and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide. The induction of HNSCC has been ascribed to the abuse of tobacco, alcohol, and areca, to human papillomavirus infection, and to exposure to a number of other carcinogenic substances. The 5‐year survival rate for HNSCC remains low and, therefore, it has become important to explore in detail the molecular alterations that contribute to the development of HNSCC, both from the point of identifying tumor markers, and with the aim of improving choices in terms of therapeutic regimens.MicroRNAs (miRNAs) are noncoding RNAs that downregulate the expression of targeted genes by binding to the specific sequences in the 3′untranslated region (UTR) of the transcript via seed sequences. Many miRNAs are involved in the neoplastic process associated with HNSCC. Our previous studies have shown that there is drastic upregulation of miR‐31 in HNSCC. This upregulation can be evoked by activation of the epidermal growth factor receptor‐AKT‐CEBP/ß signaling cascade. Furthermore, miR‐31 enhances HNSCC oncogenicity by targeting FIH, Ku80, and ARID1A, which activates the hypoxia pathway, impairs gene repair, and enhances stemness properties. Additional oncogenic miRNAs also co‐target FIH together with miR‐31. The presence of salivary/serological miR‐31 has been validated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Head & Neck: Journal for the Sciences & Specialties of the Head and Neck Wiley

Loading next page...
 
/lp/wiley/targeting-of-mir-31-96-182-to-the-numb-gene-during-head-and-neck-ac4bBJWIQb
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
1043-3074
eISSN
1097-0347
D.O.I.
10.1002/hed.25063
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONHead and neck squamous cell carcinoma (HNSCC) is the sixth most prevalent malignancy worldwide. The induction of HNSCC has been ascribed to the abuse of tobacco, alcohol, and areca, to human papillomavirus infection, and to exposure to a number of other carcinogenic substances. The 5‐year survival rate for HNSCC remains low and, therefore, it has become important to explore in detail the molecular alterations that contribute to the development of HNSCC, both from the point of identifying tumor markers, and with the aim of improving choices in terms of therapeutic regimens.MicroRNAs (miRNAs) are noncoding RNAs that downregulate the expression of targeted genes by binding to the specific sequences in the 3′untranslated region (UTR) of the transcript via seed sequences. Many miRNAs are involved in the neoplastic process associated with HNSCC. Our previous studies have shown that there is drastic upregulation of miR‐31 in HNSCC. This upregulation can be evoked by activation of the epidermal growth factor receptor‐AKT‐CEBP/ß signaling cascade. Furthermore, miR‐31 enhances HNSCC oncogenicity by targeting FIH, Ku80, and ARID1A, which activates the hypoxia pathway, impairs gene repair, and enhances stemness properties. Additional oncogenic miRNAs also co‐target FIH together with miR‐31. The presence of salivary/serological miR‐31 has been validated

Journal

Head & Neck: Journal for the Sciences & Specialties of the Head and NeckWiley

Published: Jan 1, 2018

Keywords: ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial