Systemic manifestations of periodontitis in the non‐human primate

Systemic manifestations of periodontitis in the non‐human primate This report describes our findings regarding the potential contribution of periodontitis to atherosclerotic processes using a nonhuman primate model. The goal of the investigations was to target general mechanisms which could describe the association of these disease processes, including: (i) systemic translocation of bacteria/products during periodontitis; (ii) alterations in systemic inflammatory biomarkers during periodontitis; and (iii) the relationship of periodontitis to serum lipids /lipoproteins. Increases in serum endotoxin (e.g. LPS) during ligature‐induced periodontitis were observed in these animals. We determined serum levels of various acute phase reactants and chemokines (e.g. CRP. α1‐antitrypsin, haptogiobin, fibrinogen, IL‐8). A number of these host factors were significantly increased during gingivitis and/or periodontitis. Finally, we observed specific changes in serum lipid levels (cholesterol, triglycerides, HDL, LDL) and lipoproteins (apoA‐I) during periodontitis, which were exacerbated by exposure of the animals to a diet with elevated fat content. Thus, we have described systemic manifestations of periodontitis that include detection of bacterial products, inflammatory biomarkers, and dyslipoproteinemia consistent with an increased atherogenic risk. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Periodontal Research Wiley

Systemic manifestations of periodontitis in the non‐human primate

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Publisher
Wiley
Copyright
Copyright © 1999 Wiley Subscription Services
ISSN
0022-3484
eISSN
1600-0765
D.O.I.
10.1111/j.1600-0765.1999.tb02266.x
Publisher site
See Article on Publisher Site

Abstract

This report describes our findings regarding the potential contribution of periodontitis to atherosclerotic processes using a nonhuman primate model. The goal of the investigations was to target general mechanisms which could describe the association of these disease processes, including: (i) systemic translocation of bacteria/products during periodontitis; (ii) alterations in systemic inflammatory biomarkers during periodontitis; and (iii) the relationship of periodontitis to serum lipids /lipoproteins. Increases in serum endotoxin (e.g. LPS) during ligature‐induced periodontitis were observed in these animals. We determined serum levels of various acute phase reactants and chemokines (e.g. CRP. α1‐antitrypsin, haptogiobin, fibrinogen, IL‐8). A number of these host factors were significantly increased during gingivitis and/or periodontitis. Finally, we observed specific changes in serum lipid levels (cholesterol, triglycerides, HDL, LDL) and lipoproteins (apoA‐I) during periodontitis, which were exacerbated by exposure of the animals to a diet with elevated fat content. Thus, we have described systemic manifestations of periodontitis that include detection of bacterial products, inflammatory biomarkers, and dyslipoproteinemia consistent with an increased atherogenic risk.

Journal

Journal of Periodontal ResearchWiley

Published: Jan 1, 1999

Keywords: ; ; ; ;

References

  • Atherosclerosis renews
    Libby, P.
  • Infant diet affects serum lipoprotein concentrations and cholesterol esterifying enzymes in baboons
    Mott, GE; Lewis, DS; McMahan, CA.
  • Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of preparative ultracentrifuge
    Friedewald, WT; Levy, RI; Fredrickson, DS.

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