Systemic Inflammatory Markers, Periodontal Diseases, and Periodontal Infections in an Elderly Population

Systemic Inflammatory Markers, Periodontal Diseases, and Periodontal Infections in an Elderly... Objectives: To study the levels of systemic markers for inflammation with parameters of periodontal diseases in older people. Design: A cross‐sectional study was conducted in a cohort that is being followed prospectively on the effects of aging and body composition on morbidity. Setting: University of Pittsburgh, Pittsburgh, and University of Tennessee, Memphis. Participants: One thousand one hundred thirty‐one participants (mean age±standard deviation 72.7±2.8); 66% white and 50% male. Measurements: Periodontal examination, including probing depth and attachment loss, was performed. Periodontal disease extent was divided into 0% of sites with probing depth of 6 mm or more, 1% to 10% of sites with probing depth of 6 mm or more and more than 10% of sites with probing depth of 6 mm or more. Subgingival plaque samples were collected from four molar teeth, and the levels of periodontal pathogens were determined using the benzoyl‐DL‐arginine‐naphthylamide (BANA) test. Plasma interleukin‐6 (IL‐6), C‐reactive protein (CRP), plasminogen activator inhibitor type‐1 (PAI‐1), and tumor necrosis factor alpha (TNF‐α) levels were measured in all participants. Assessments of risk factors associated with elevated levels of markers of systemic inflammation were also determined. Multiple regression analysis was employed to analyze the data. Results: IL‐6 levels were significantly higher in participants with more‐extensive periodontal disease than in other participants. Periodontal disease extent was significantly associated with higher TNF‐α plasma levels, controlling for established risk factors for elevated TNF‐α levels. Participants with BANA‐positive species had significantly higher CRP plasma levels when controlling for risk factors for elevated CRP levels. Conclusion: Periodontal disease and infection may be modifiable risk indicators for elevated levels of systemic inflammatory markers in older people. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

Systemic Inflammatory Markers, Periodontal Diseases, and Periodontal Infections in an Elderly Population

Loading next page...
 
/lp/wiley/systemic-inflammatory-markers-periodontal-diseases-and-periodontal-7BBcssa0zy
Publisher site
See Article on Publisher Site

Abstract

Objectives: To study the levels of systemic markers for inflammation with parameters of periodontal diseases in older people. Design: A cross‐sectional study was conducted in a cohort that is being followed prospectively on the effects of aging and body composition on morbidity. Setting: University of Pittsburgh, Pittsburgh, and University of Tennessee, Memphis. Participants: One thousand one hundred thirty‐one participants (mean age±standard deviation 72.7±2.8); 66% white and 50% male. Measurements: Periodontal examination, including probing depth and attachment loss, was performed. Periodontal disease extent was divided into 0% of sites with probing depth of 6 mm or more, 1% to 10% of sites with probing depth of 6 mm or more and more than 10% of sites with probing depth of 6 mm or more. Subgingival plaque samples were collected from four molar teeth, and the levels of periodontal pathogens were determined using the benzoyl‐DL‐arginine‐naphthylamide (BANA) test. Plasma interleukin‐6 (IL‐6), C‐reactive protein (CRP), plasminogen activator inhibitor type‐1 (PAI‐1), and tumor necrosis factor alpha (TNF‐α) levels were measured in all participants. Assessments of risk factors associated with elevated levels of markers of systemic inflammation were also determined. Multiple regression analysis was employed to analyze the data. Results: IL‐6 levels were significantly higher in participants with more‐extensive periodontal disease than in other participants. Periodontal disease extent was significantly associated with higher TNF‐α plasma levels, controlling for established risk factors for elevated TNF‐α levels. Participants with BANA‐positive species had significantly higher CRP plasma levels when controlling for risk factors for elevated CRP levels. Conclusion: Periodontal disease and infection may be modifiable risk indicators for elevated levels of systemic inflammatory markers in older people.

Journal

Journal of American Geriatrics SocietyWiley

Published: Sep 1, 2005

References

  • Microbial complexes in subgingival plaque
    Socransky, Socransky; Haffajee, Haffajee; Cugini, Cugini
  • Variability in the measurement of C‐reactive protein in healthy subjects
    Macy, Macy; Hayes, Hayes; Tracy, Tracy
  • Acute‐phase reactants in infections and inflammatory diseases
    Ebersole, Ebersole; Cappelli, Cappelli
  • The plasminogen activating system in periodontal health and disease
    Kinnby, Kinnby
  • Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition (Health ABC) Study)
    Cesari, Cesari; Penninx, Penninx; Newman, Newman

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off