Access the full text.
Sign up today, get DeepDyve free for 14 days.
C. Bock, E. Kiskinis, G. Verstappen, H. Gu, G. Boulting, Zachary Smith, M. Ziller, Gist Croft, Mackenzie Mathis, Derek Oakley, A. Gnirke, K. Eggan, A. Meissner (2011)
Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell LinesCell, 144
B. Neumann, Thomas Walter, J. Hériché, Jutta Bulkescher, H. Erfle, C. Conrad, Phill Rogers, I. Poser, Michael Held, U. Liebel, Cihan Çetin, F. Sieckmann, Grégoire Pau, Rolf Kabbe, Annelie Wünsche, V. Satagopam, Michael Schmitz, Catherine Chapuis, D. Gerlich, Reinhard Schneider, R. Eils, W. Huber, J. Peters, A. Hyman, R. Durbin, R. Pepperkok, J. Ellenberg (2010)
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genesNature, 464
Andrew Cohen, B. Roysam, J. Turner, J. Turner (1994)
Automated tracing and volume measurements of neurons from 3‐D confocal fluorescence microscopy dataJournal of Microscopy, 173
Anne Carpenter, T. Jones, M. Lamprecht, C. Clarke, In Kang, O. Friman, D. Guertin, Joo Chang, Robert Lindquist, J. Moffat, P. Golland, D. Sabatini (2006)
CellProfiler: image analysis software for identifying and quantifying cell phenotypesGenome Biology, 7
L. Ding, Maciej Paszkowski-Rogacz, A. Nitzsche, Mikołaj Słabicki, Anne-Kristin Heninger, I. Vries, R. Kittler, M. Junqueira, A. Shevchenko, H. Schulz, N. Hubner, M. Doss, A. Sachinidis, J. Hescheler, R. Iacone, K. Anastassiadis, A. Stewart, M. Pisabarro, A. Caldarelli, I. Poser, Mirko Theis, F. Buchholz (2009)
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.Cell stem cell, 4 5
A. Moretti, M. Bellin, A. Welling, C. Jung, J. Lam, Lorenz Bott-Flügel, T. Dorn, Alexander Goedel, C. Höhnke, F. Hofmann, M. Seyfarth, D. Sinnecker, A. Schömig, K. Laugwitz (2010)
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.The New England journal of medicine, 363 15
Kazutoshi Takahashi, K. Tanabe, M. Ohnuki, Megumi Narita, T. Ichisaka, K. Tomoda, S. Yamanaka (2007)
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell, 131
D. Rines, M. Gómez-Ferrería, Yingyao Zhou, Paul DeJesus, Seanna Grob, Serge Batalov, M. Labow, Dieter Huesken, C. Mickanin, Jonathan Hall, Mischa Reinhardt, F. Natt, Joerg Lange, D. Sharp, S. Chanda, J. Caldwell (2008)
Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cellsGenome Biology, 9
O. Dürr, François Duval, A. Nichols, Paul Lang, Annette Brodte, S. Heyse, Dominique Besson (2007)
Robust Hit Identification by Quality Assurance and Multivariate Data Analysis of a High-Content, Cell-Based AssayJournal of Biomolecular Screening, 12
In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, A. Shimamura, M. Lensch, Chad Cowan, K. Hochedlinger, G. Daley (2008)
Disease-Specific Induced Pluripotent Stem CellsCell, 134
Ivana Barbaric, P. Gokhale, Mark Jones, Adam Glen, D. Baker, P. Andrews (2010)
Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies.Stem cell research, 5 2
Gang Lin, U. Adiga, K. Olson, J. Guzowski, C. Barnes, B. Roysam (2003)
A hybrid 3D watershed algorithm incorporating gradient cues and object models for automatic segmentation of nuclei in confocal image stacksCytometry Part A, 56A
Xiaofan Xu, Victoria Browning, J. Odorico (2011)
Activin, BMP and FGF pathways cooperate to promote endoderm and pancreatic lineage cell differentiation from human embryonic stem cellsMechanisms of Development, 128
M. Kagey, J. Newman, S. Bilodeau, Y. Zhan, David Orlando, Nynke Berkum, Christopher Ebmeier, J. Goossens, P. Rahl, S. Levine, D. Taatjes, J. Dekker, R. Young (2010)
Mediator and Cohesin Connect Gene Expression and Chromatin ArchitectureNature, 467
R. Redmon (2021)
IdentityNotre Dame J. Formal Log., 16
A. Grigoriadis, M. Kennedy, A. Bozec, Fiona Brunton, G. Stenbeck, In-Hyun Park, E. Wagner, G. Keller (2010)
Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.Blood, 115 14
Yifang Song, A. Bahnson, Nathan Hall, Hui Yu, Hongmei Shen, D. Koebler, R. Houck, Yi Xie, T. Cheng (2009)
Stem Cell Traits in Long-term Co-culture Revealed by Time-lapse ImagingLeukemia, 24
M. Halter, D. Sisan, J. Chalfoun, B. Stottrup, Antonio Cardone, A. Dima, A. Tona, A. Plant, J. Elliott (2011)
Cell cycle dependent TN‐C promoter activity determined by live cell imagingCytometry Part A, 79A
Siwei Yang, Daniela Köhler, Kathrin Teller, T. Cremer, P. Baccon, Edith Heard, R. Eils, K. Rohr (2008)
Nonrigid Registration of 3-D Multichannel Microscopy Images of Cell NucleiIEEE Transactions on Image Processing, 17
D. Johnston (2002)
The art and design of genetic screens: Drosophila melanogasterNature Reviews Genetics, 3
G. Dietzl, Doris Chen, F. Schnorrer, Kuan-Chung Su, Yu. Barinova, M. Fellner, Beate Gasser, Kaolin Kinsey, Silvia Oppel, Susanne Scheiblauer, Africa Couto, Vincent Marra, K. Keleman, B. Dickson (2007)
A genome-wide transgenic RNAi library for conditional gene inactivation in DrosophilaNature, 448
Ivana Barbaric, Mark Jones, D. Harley, P. Gokhale, P. Andrews (2011)
High-Content Screening for Chemical Modulators of Embryonal Carcinoma Cell Differentiation and SurvivalJournal of Biomolecular Screening, 16
Huixia Li, Xiao Luo, Rong Liu, Yingjuan Yang, Gongshe Yang (2008)
Roles of Wnt/β-catenin signaling in adipogenic differentiation potential of adipose-derived mesenchymal stem cellsMolecular and Cellular Endocrinology, 291
N. A. Hamilton, R. S. Pantelic, K. Hanson, R. D. Teasdale (2007)
Fast automated cell phenotype image classification., 8
L. Shamir, John Delaney, Nikita Orlov, D. Eckley, I. Goldberg (2010)
Pattern Recognition Software and Techniques for Biological Image AnalysisPLoS Computational Biology, 6
Grégoire Pau, Florian Fuchs, O. Sklyar, M. Boutros, W. Huber (2010)
EBImage—an R package for image processing with applications to cellular phenotypesBioinformatics, 26
G. Lin, K. Hankenson (2011)
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiationJournal of Cellular Biochemistry, 112
A. Lund, B. Yener, J. Stegemann, G. Plopper (2009)
The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination.Tissue engineering. Part B, Reviews, 15 3
L. Loo, Lani Wu, S. Altschuler (2007)
Image-based multivariate profiling of drug responses from single cellsNature Methods, 4
G. Hu, Jonghwan Kim, Qikai Xu, Yumei Leng, S. Orkin, S. Elledge (2009)
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.Genes & development, 23 7
Shuibing Chen, J. Do, Qisheng Zhang, Shuyuan Yao, Feng Yan, E. Peters, H. Schöler, P. Schultz, Sheng Ding (2006)
Self-renewal of embryonic stem cells by a small moleculeProceedings of the National Academy of Sciences, 103
Paul Lang, K. Yeow, A. Nichols, A. Scheer (2006)
Cellular imaging in drug discoveryNature Reviews Drug Discovery, 5
Hanchuan Peng, Fuhui Long, C. Ding (2003)
Feature selection based on mutual information criteria of max-dependency, max-relevance, and min-redundancyIEEE Transactions on Pattern Analysis and Machine Intelligence, 27
J. Fairfield (1983)
Segmenting Dot Patterns by Voronoi Diagram ConcavityIEEE Transactions on Pattern Analysis and Machine Intelligence, PAMI-5
C. Conrad, D. Gerlich (2010)
Automated microscopy for high-content RNAi screeningThe Journal of Cell Biology, 188
S. Sherman, Jackelyn Alva, Kaushali Thakore-Shah, A. Pyle (2011)
Human pluripotent stem cells: the development of high-content screening strategies.Methods in molecular biology, 767
Zachary Smith, I. Nachman, A. Regev, A. Meissner (2010)
Dynamic single-cell imaging of direct reprogramming reveals an early specifying eventNature Biotechnology, 28
Jessica Risner-Janiczek, M. Ungless, Meng Li (2011)
Electrophysiological Properties of Embryonic Stem Cell-Derived NeuronsPLoS ONE, 6
R. Pepperkok, J. Ellenberg (2006)
High-throughput fluorescence microscopy for systems biologyNature Reviews Molecular Cell Biology, 7
Abujarour (2010)
Genome-wide gain-of-function screen identifies novel regulators of pluripotency.Stem Cells, 28
S. Haney, P. LaPan, Jing Pan, Jing Zhang (2006)
High-content screening moves to the front of the line.Drug discovery today, 11 19-20
J. Tyrrell, E. Tomaso, D. Fuja, Ricky Tong, Kevin Kozak, R. Jain, B. Roysam (2007)
Robust 3-D Modeling of Vasculature Imagery Using SuperellipsoidsIEEE Transactions on Medical Imaging, 26
Shoutian Zhu, H. Wurdak, Jian Wang, C. Lyssiotis, E. Peters, C. Cho, Xu Wu, P. Schultz (2009)
A small molecule primes embryonic stem cells for differentiation.Cell stem cell, 4 5
G. Spangrude (2003)
When is a stem cell really a stem cell?Bone Marrow Transplantation, 32
P. Bushway, M. Mercola (2006)
High-throughput screening for modulators of stem cell differentiation.Methods in enzymology, 414
N. Shiraki, Taiji Yamazoe, Zeng Qin, Keiko Ohgomori, K. Mochitate, K. Kume, S. Kume (2011)
Efficient Differentiation of Embryonic Stem Cells into Hepatic Cells In Vitro Using a Feeder-Free Basement Membrane SubstratumPLoS ONE, 6
O. Hartung, Hongguang Huo, G. Daley, T. Schlaeger (2010)
Clump passaging and expansion of human embryonic and induced pluripotent stem cells on mouse embryonic fibroblast feeder cells.Current protocols in stem cell biology, Chapter 1
E. Willems, Sean Spiering, Herman Davidovics, M. Lanier, Zebin Xia, M. Dawson, J. Cashman, M. Mercola (2011)
Small-Molecule Inhibitors of the Wnt Pathway Potently Promote Cardiomyocytes From Human Embryonic Stem Cell–Derived MesodermCirculation Research, 109
A. Pessina, L. Gribaldo (2006)
The key role of adult stem cells: therapeutic perspectivesCurrent Medical Research and Opinion, 22
Christina Falschlehner, Sandra Steinbrink, G. Erdmann, M. Boutros (2010)
High‐throughput RNAi screening to dissect cellular pathways: A how‐to guideBiotechnology Journal, 5
Weimiao Yu, Hwee Lee, Srivats Hariharan, Wenyu Bu, Sohail Ahmed (2010)
Evolving generalized Voronoi diagrams for accurate cellular image segmentationCytometry Part A, 77A
Shuibing Chen, M. Borowiak, Julia Fox, R. Maehr, K. Osafune, L. Davidow, Kelvin Lam, Lee Peng, S. Schreiber, L. Rubin, D. Melton (2009)
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.Nature chemical biology, 5 4
F. Müller, Bernhard Schuldt, Roy Williams, D. Mason, G. Altun, E. Papapetrou, S. Danner, J. Goldman, Arne Herbst, N. Schmidt, Josef Aldenhoff, L. Laurent, J. Loring (2011)
A bioinformatic assay for pluripotency in human cellsNature methods, 8
Hua Liu, Zhaohui Ye, Yonghak Kim, S. Sharkis, Yoon-Young Jang (2010)
Generation of endoderm‐derived human induced pluripotent stem cells from primary hepatocytesHepatology, 51
T. Jones, Anne Carpenter, M. Lamprecht, J. Moffat, S. Silver, J. Grenier, Adam Castoreno, U. Eggert, D. Root, P. Golland, D. Sabatini (2009)
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learningProceedings of the National Academy of Sciences, 106
Stuart Chambers, Yvonne Mica, L. Studer, M. Tomishima (2011)
Converting human pluripotent stem cells to neural tissue and neurons to model neurodegeneration.Methods in molecular biology, 793
N. Ali, C. Karlsson, Marie Aspling, G. Hu, N. Hacohen, D. Scadden, Jonas Larsson (2009)
Forward RNAi screens in primary human hematopoietic stem/progenitor cells.Blood, 113 16
Huisheng Liu, Su-Chun Zhang (2011)
Specification of neuronal and glial subtypes from human pluripotent stem cellsCellular and Molecular Life Sciences, 68
Michael Held, Michael Schmitz, Bernd Fischer, Thomas Walter, B. Neumann, Michael Olma, M. Peter, J. Ellenberg, D. Gerlich (2010)
CellCognition: time-resolved phenotype annotation in high-throughput live cell imagingNature Methods, 7
Wen Guo, J. Flanagan, R. Jasuja, J. Kirkland, Lan Jiang, S. Bhasin (2008)
The Effects of Myostatin on Adipogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells Are Mediated through Cross-communication between Smad3 and Wnt/β-Catenin Signaling Pathways*Journal of Biological Chemistry, 283
Jianhua Zhang, G. Wilson, A. Soerens, Chad Koonce, Junying Yu, S. Palecek, J. Thomson, T. Kamp (2009)
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem CellsCirculation Research, 104
A. Vitale, E. Wolvetang, A. Mackay-Sim (2011)
Induced pluripotent stem cells: a new technology to study human diseases.The international journal of biochemistry & cell biology, 43 6
A. Behfar, A. Terzic (2006)
Derivation of a cardiopoietic population from human mesenchymal stem cells yields cardiac progenyNature Clinical Practice Cardiovascular Medicine, 3 Suppl 1
M. Boutros, J. Ahringer (2008)
The art and design of genetic screens: RNA interferenceNature Reviews Genetics, 9
P. Santamaria, I. Rodríguez-Pizá, X. Clemente-Casares, J. Yamanouchi, Lola Mulero-Perez, T. Aasen, Á. Raya, J. Belmonte (2010)
Turning human epidermis into pancreatic endoderm.The review of diabetic studies : RDS, 7 2
(2007)
BMC Bioinformatics BioMed Central Methodology article Fast automated cell phenotype image classification
Ting Zhao, R. Murphy (2007)
Automated learning of generative models for subcellular location: Building blocks for systems biologyCytometry Part A, 71A
Laura Dickinson, S. Kusuma, S. Gerecht (2011)
Reconstructing the differentiation niche of embryonic stem cells using biomaterials.Macromolecular bioscience, 11 1
Na-Yu Chia, Yun-Shen Chan, Bo Feng, Xinyi Lu, Y. Orlov, D. Moreau, Pankaj Kumar, Lin Yang, Jianming Jiang, M. Lau, M. Huss, B. Soh, P. Kraus, Pin Li, T. Lufkin, B. Lim, N. Clarke, F. Bard, H. Ng (2010)
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identityNature, 468
Kazutoshi Takahashi, S. Yamanaka (2006)
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell, 126
Mark Tibbitt, K. Anseth (2009)
Hydrogels as extracellular matrix mimics for 3D cell culture.Biotechnology and bioengineering, 103 4
Molecular Systems Biology 6; Article number 370; doi:10.1038/msb.2010.25 Citation: Molecular Systems Biology 6:370
M. Treiser, E. Yang, S. Gordonov, Daniel Cohen, I. Androulakis, J. Kohn, Christopher Chen, P. Moghe (2009)
Cytoskeleton-based forecasting of stem cell lineage fatesProceedings of the National Academy of Sciences, 107
P. Horvath, T. Wild, U. Kutay, G. Csucs (2011)
Machine learning improves the precision and robustness of high‐content screens: using nonlinear multiparametric methods to analyze screening results., 16
M. Moors, R. Bose, K. Johansson-Haque, K. Edoff, S. Okret, S. Ceccatelli (2012)
Dickkopf 1 mediates glucocorticoid-induced changes in human neural progenitor cell proliferation and differentiation.Toxicological sciences : an official journal of the Society of Toxicology, 125 2
P. Burridge, Susan Thompson, Michal Millrod, Seth Weinberg, Xuan Yuan, Ann Peters, V. Mahairaki, V. Koliatsos, L. Tung, Elias Zambidis (2011)
A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline VariabilityPLoS ONE, 6
K. Kilian, Branimir Bugarija, B. Lahn, M. Mrksich (2010)
Geometric cues for directing the differentiation of mesenchymal stem cellsProceedings of the National Academy of Sciences, 107
Dai Ker, L. Weiss, Silvina Junkers, Mei Chen, Zhaozheng Yin, Michael Sandbothe, Seungil Huh, Sungeun Eom, Ryoma Bise, Elvira Osuna-Highley, T. Kanade, P. Campbell (2011)
An Engineered Approach to Stem Cell Culture: Automating the Decision Process for Real-Time Adaptive Subculture of Stem CellsPLoS ONE, 6
A. Ebert, Junying Yu, F. Rose, Virginia Mattis, C. Lorson, J. Thomson, C. Svendsen (2009)
Induced pluripotent stem cells from a spinal muscular atrophy patientNature, 457
K. Al-Kofahi, S. Lasek, D. Szarowski, Christopher Pace, G. Nagy, J. Turner, B. Roysam (2002)
Rapid automated three-dimensional tracing of neurons from confocal image stacksIEEE Transactions on Information Technology in Biomedicine, 6
P. Chong, L. Selvaratnam, A. Abbas, T. Kamarul (2012)
Human peripheral blood derived mesenchymal stem cells demonstrate similar characteristics and chondrogenic differentiation potential to bone marrow derived mesenchymal stem cellsJournal of Orthopaedic Research, 30
D. Danovi, Anna Falk, Peter Humphreys, R. Vickers, J. Tinsley, Austin Smith, S. Pollard (2010)
Imaging-based chemical screens using normal and glioma-derived neural stem cells.Biochemical Society transactions, 38 4
N. Malpica, C. Solórzano, J. Vaquero, Andrés Santos, I. Vallcorba, J. García-Sagredo, F. Pozo (1998)
Applying watershed algorithms to the segmentation of clustered nuclei.Cytometry, 28 4
Fuchs (2010)
Clustering phenotype populations by genome-wide RNAi and multiparametric imaging.Mol. Syst. Biol., 6
T. Kraehenbuehl, R. Langer, L. Ferreira (2011)
Three-dimensional biomaterials for the study of human pluripotent stem cellsNature Methods, 8
A. Ebert, C. Svendsen (2010)
Human stem cells and drug screening: opportunities and challengesNature Reviews Drug Discovery, 9
E. Jorgensen, S. Mango (2002)
The art and design of genetic screens: Caenorhabditis elegansNature Reviews Genetics, 3
M. Ronzière, E. Perrier, F. Mallein-Gerin, A. Freyria (2010)
Chondrogenic potential of bone marrow- and adipose tissue-derived adult human mesenchymal stem cells.Bio-medical materials and engineering, 20 3
R. Damoiseaux, S. Sherman, Jackelyn Alva, C. Peterson, A. Pyle (2009)
Integrated Chemical Genomics Reveals Modifiers of Survival in Human Embryonic Stem CellsSTEM CELLS, 27
Florian Fuchs, M. Boutros (2006)
Cellular phenotyping by RNAi.Briefings in functional genomics & proteomics, 5 1
J. Klenk (2007)
Characteristics and value of machine learning for imaging in high content screening.Methods in molecular biology, 356
C. Nüsslein-Volhard, E. Wieschaus (1980)
Mutations affecting segment number and polarity in DrosophilaNature, 287
Lei Yang, M. Soonpaa, Eric Adler, T. Roepke, Steven Kattman, M. Kennedy, E. Henckaerts, Kristina Bonham, G. Abbott, R. Linden, L. Field, G. Keller (2008)
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived populationNature, 453
M. Bickle (2010)
The beautiful cell: high-content screening in drug discoveryAnalytical and Bioanalytical Chemistry, 398
D. D’Amario, Claudia Fiorini, P. Campbell, P. Goichberg, Fumihiro Sanada, Hanqiao Zheng, T. Hosoda, M. Rota, J. Connell, R. Gallegos, F. Welt, M. Givertz, R. Mitchell, A. Leri, J. Kajstura, M. Pfeffer, P. Anversa (2011)
Functionally Competent Cardiac Stem Cells Can Be Isolated From Endomyocardial Biopsies of Patients With Advanced CardiomyopathiesCirculation Research, 108
Nitzan Rimon, M. Schuldiner (2011)
Getting the whole picture: combining throughput with content in microscopyJournal of Cell Science, 124
T. Liu, D. Sims, B. Baum (2009)
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphologyGenome Biology, 10
Xiaobo Zhou, Kuang-Yu Liu, P. Bradley, N. Perrimon, Stephen Wong (2005)
Towards Automated Cellular Image Segmentation for RNAi Genome-Wide ScreeningMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 8 Pt 1
S. Pearson, P. Sroczyńska, G. Lacaud, V. Kouskoff (2008)
The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF, 135
Sabrina Desbordes, D. Placantonakis, A. Ciro, N. Socci, Gabsang Lee, Hakim Djaballah, L. Studer (2008)
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.Cell stem cell, 2 6
Ramzey Abujarour, J. Efe, Sheng Ding (2010)
EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS Genome-Wide Gain-of-Function Screen Identifies Novel Regulators of Pluripotency
A. Shariff, Joshua Kangas, Luis Coelho, Shannon Quinn, R. Murphy (2010)
Automated Image Analysis for High-Content Screening and AnalysisJournal of Biomolecular Screening, 15
Gowri Srinivasa, M. Fickus, Yusong Guo, A. Linstedt, J. Kovacevic (2009)
Active Mask Segmentation of Fluorescence Microscope ImagesIEEE Transactions on Image Processing, 18
N. Perrimon, B. Mathey-Prevot (2007)
Applications of High-Throughput RNA Interference Screens to Problems in Cell and Developmental BiologyGenetics, 175
W. Cawthorn, Adam Bree, Yao Yao, Baowen Du, N. Hemati, Gabriel Martinez-Santibanez, O. MacDougald (2012)
Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.Bone, 50 2
P. Alberton, C. Popov, M. Prägert, J. Kohler, C. Shukunami, M. Schieker, D. Docheva (2012)
Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis.Stem cells and development, 21 6
D. Davis, Yiqiang Zhang, R. Smith, K. Cheng, J. Terrovitis, K. Malliaras, Tao-Sheng Li, A. White, R. Makkar, E. Marbán (2009)
Validation of the Cardiosphere Method to Culture Cardiac Progenitor Cells from Myocardial TissuePLoS ONE, 4
Paul Gadue, T. Huber, Patrick Paddison, G. Keller (2006)
Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cellsProceedings of the National Academy of Sciences, 103
A. Fraser, R. Kamath, Peder Zipperlen, Maruxa Martínez‐Campos, M. Sohrmann, J. Ahringer (2000)
Functional genomic analysis of C. elegans chromosome I by systematic RNA interferenceNature, 408
T. Fazzio, Jason Huff, B. Panning (2008)
An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell IdentityCell, 134
Péter Horváth, T. Wild, U. Kutay, G. Csucs (2011)
Machine Learning Improves the Precision and Robustness of High-Content ScreensJournal of Biomolecular Screening, 16
S. Chirieleison, Taylor Bissell, Christopher Scelfo, Jordan Anderson, Yong Li, D. Koebler, B. Deasy (2011)
Automated live cell imaging systems reveal dynamic cell behaviorBiotechnology Progress, 27
Wenyun He, Thomas Hamilton, Andrew Cohen, T. Holmes, Christopher Pace, D. Szarowski, J. Turner, B. Roysam (2003)
Automated Three-Dimensional Tracing of Neurons in Confocal and Brightfield ImagesMicroscopy and Microanalysis, 9
High‐throughput RNAi or small molecule screens have proven to be powerful methodologies for the systematic dissection of cellular processes. In model organisms and cell lines, large‐scale screens have identified key components of many cellular pathways and helped to identify novel targets in disease‐relevant pathways. Image‐based high‐content screening has become an increasingly important tool in high‐throughput screening, enabling changes in phenotype characteristics, such as cell morphology and cell differentiation, to be monitored. In this review, we discuss the use of image‐based screening approaches to explore the behavior of adult, embryonic, and induced pluripotent stem cells. First, we review how current pluripotency and differentiation assays can be adapted to high‐throughput formats. We then describe general aspects of image‐based screening of cells and present an outlook on challenges for screening stem cells.
Biotechnology Journal – Wiley
Published: Jun 1, 2012
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.