Synthesis of a New Series of N‐Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases

Synthesis of a New Series of N‐Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical... The reaction of isatin 1 with benzaldehyde and a sec‐amine or the appropriate aldimine afforded the N‐Mannich bases 2–3 and the bis‐base 4. Treatment of 1 with glutaric dialdehyde and morpholine gave the bis‐base 5. Mannich reaction of the Schiff bases 6a–f derived from 1, led to the new Mannich bases and bis‐bases 7–9. The use of N‐methyl‐D‐glucamine as the amine component in the Mannich reaction with 6b–f led to the polyhydroxy Mannich bases 11–13. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Heterocyclic Chemistry Wiley

Synthesis of a New Series of N‐Mannich Bases and Polyhydroxy Mannich Bases of Pharmaceutical Interest Related to Isatin and Its Schiff Bases

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-152X
eISSN
1943-5193
D.O.I.
10.1002/jhet.3097
Publisher site
See Article on Publisher Site

Abstract

The reaction of isatin 1 with benzaldehyde and a sec‐amine or the appropriate aldimine afforded the N‐Mannich bases 2–3 and the bis‐base 4. Treatment of 1 with glutaric dialdehyde and morpholine gave the bis‐base 5. Mannich reaction of the Schiff bases 6a–f derived from 1, led to the new Mannich bases and bis‐bases 7–9. The use of N‐methyl‐D‐glucamine as the amine component in the Mannich reaction with 6b–f led to the polyhydroxy Mannich bases 11–13.

Journal

Journal of Heterocyclic ChemistryWiley

Published: Jan 1, 2018

References

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