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Synthesis and release of neuroactive substances by glial cells

Synthesis and release of neuroactive substances by glial cells Glia contain, synthesize, or release more than 20 neuroactive compounds including neuropeptides, amino acid transmitters, eicosanoids, steroids, and growth factors. The stimuli that elicit release differ among compounds but include neuropeptides, neurotransmitters, receptor agonists, and elevated external (K+). The mechanisms of release are poorly understood in most cases. Many of the neuroactive compounds are localized in discrete subpopulations of glia. Thus, glia are equipped to send as well as receive chemical messages and appear to be present as classes of cells with differing abilities to communicate chemically. It is possible that glia are as diverse as neurons in their functional characteristics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Glia Wiley

Synthesis and release of neuroactive substances by glial cells

Glia , Volume 5 (2) – Jan 1, 1992

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References (156)

Publisher
Wiley
Copyright
Copyright © 1992 Wiley‐Liss, Inc.
ISSN
0894-1491
eISSN
1098-1136
DOI
10.1002/glia.440050202
pmid
1349588
Publisher site
See Article on Publisher Site

Abstract

Glia contain, synthesize, or release more than 20 neuroactive compounds including neuropeptides, amino acid transmitters, eicosanoids, steroids, and growth factors. The stimuli that elicit release differ among compounds but include neuropeptides, neurotransmitters, receptor agonists, and elevated external (K+). The mechanisms of release are poorly understood in most cases. Many of the neuroactive compounds are localized in discrete subpopulations of glia. Thus, glia are equipped to send as well as receive chemical messages and appear to be present as classes of cells with differing abilities to communicate chemically. It is possible that glia are as diverse as neurons in their functional characteristics.

Journal

GliaWiley

Published: Jan 1, 1992

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