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Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers

Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)‐based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on‐demand fabrication of hydrogels. For rapid gelation, a hydrazide‐functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG‐based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Macromolecular Rapid Communications Wiley

Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers

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References (24)

Publisher
Wiley
Copyright
"Copyright © 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim"
ISSN
1022-1336
eISSN
1521-3927
DOI
10.1002/marc.201300909
pmid
24522984
Publisher site
See Article on Publisher Site

Abstract

The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)‐based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on‐demand fabrication of hydrogels. For rapid gelation, a hydrazide‐functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG‐based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds.

Journal

Macromolecular Rapid CommunicationsWiley

Published: Apr 1, 2014

Keywords: ; ; ; ;

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