Access the full text.
Sign up today, get DeepDyve free for 14 days.
Baumann (1974)
538J. Supramol. Struct., 2
K. Inouye, K. Watanabe, K. Namba, H. Otsuka (1970)
Synthesis of corticotropin peptides. XII. The effect of amino-terminal substitution in the corticotropin 1-18 peptide.Bulletin of the Chemical Society of Japan, 43 12
Irmscher (1978)
470Biochim. Biophys. Acta, 507
Jung (1974)
345
Jung (1977)
196Chemiker-Ztg., 101
Gerhard Irmscher, G. Jung (1977)
Die hämolytischen Eigenschaften der membranmodifizierenden Peptidantibiotika Alamethicin, Suzukacillin und TrichotoxinFEBS Journal, 80
(1974)
in Peptides 1974 , Proceedings of the 13 th European Peptide Symposium ,
M. Mutter, H. Mutter, R. Uhmann, E. Bayer (1976)
[Conformation studies on oligoalanines, substance P, and the myoglobin sequence (66-73). Circular dichroism of polyethyleneglycol-bound peptides].Biopolymers, 15 5
Johnson (1976)
183J. Theor. Biol., 60
Meyer (1967)
85Experientia, 23
N. Greenfield, G. Fasman (1969)
Computed circular dichroism spectra for the evaluation of protein conformation.Biochemistry, 8 10
G. Holzwarth, P. Doty (1965)
THE ULTRAVIOLET CIRCULAR DICHROISM OF POLYPEPTIDES.Journal of the American Chemical Society, 87
Boheim (1976)
182Biochim. Biophys. Acta, 433
M. Johnson (1976)
Possible three-dimensional models for the polypeptide backbone structure of alamethicin.Journal of theoretical biology, 60 01
Gordon (1975)
433Phil. Trans. R. Soc. London Ser. B, 270
E. Bayer, M. Mutter (1974)
Synthese des biologisch aktiven Undecapeptids Substanz P nach der Flüssig‐Phasen‐MethodeChemische Berichte, 107
Hauser (1970)
419J. Mol. Biol., 53
Mueller (1968)
713Nature, 217
B. Malcolm (1977)
A 310‐Helix in poly(α‐aminoisobutyric acid)Biopolymers, 16
A. Mcmullen, J. Stirrup (1971)
The aggregation of alamethicin.Biochimica et biophysica acta, 241 3
N. Greenfield, B. Davidson, G. Fasman (1967)
The use of computed optical rotatory dispersion curves for the evaluation of protein conformation.Biochemistry, 6 6
Boheim (1978)
485Biochim. Biophys. Acta, 507
G. Boheim, G. Irmscher, G. Jung (1978)
Trichotoxin A-40, a new membrane-exciting peptide. Part B. Voltage-dependent pore formation in bilayer lipid membranes and comparison with other alamethicin analogues☆Biochimica et Biophysica Acta, 507
H. Hauser, E. Finer, D. Chapman (1970)
Nuclear magnetic resonance studies of the polypeptide alamethicin and its interaction with phospholipids.Journal of molecular biology, 53 3
Burgess (1973)
2691Biopolymers, 12
G. Boheim, K. Janko, D. Leibfritz, T. Ooka, W. König, G. Jung (1976)
Structural and membrane modifying porperties of suzukacillin, a peptide antibiotic related to alamethicin. Part B. Pore formation in black lipid films.Biochimica et biophysica acta, 433 1
M. Leplawy, D. Jones, G. Kenner, R. Sheppard (1960)
Peptides—XI: Synthesis of peptides derived from alpha-methylalanineTetrahedron, 11
Irmscher (1977)
165Eur. J. Biochem., 80
Yantorno (1977)
87aBiophys. J., 17
J. Payne, Ross Jakes, Brian Hartley (1970)
The primary structure of alamethicin.The Biochemical journal, 117 4
P. Mueller, D. Rudin (1968)
Action Potentials induced in Biomolecular Lipid MembranesNature, 217
(1978)
ceedings of the European Conference on NMR of Macromolecules , Sassary , Italy , in press
C. Toniolo, G. Bonora (1975)
Structural aspects of small peptides. A circular dichroism study of monodisperse protected homo‐oligomers derived from L‐alanineMacromolecular Chemistry and Physics, 176
E. Bayer, G. Jung, H. Hagenmaier (1968)
Untersuchungen zur totalsynthese des ferredoxins—I : Synthese der aminosäuresequenz von C. pasteurianum ferredoxinTetrahedron, 24
Jung (1976)
164Biochim. Biophys. Acta, 433
Jung (1975)
395Eur. J. Biochem., 54
E. Bayer, M. Mutter (1972)
Liquid Phase Synthesis of PeptidesNature, 237
B. Hemmasi, E. Bayer (2009)
Coupling of Glutamine by the Carbodiimide Method in the Solid-Phase Synthesis of two C-Terminal Peptides of SecretinBiological Chemistry, 355
G. Jung, W. König, D. Leibfritz, T. Ooka, K. Janko, G. Boheim (1976)
Structural and membrane modifying properties of suzukacillin, a peptide antibiotic related to alamethicin. Part A. Sequence and conformation.Biochimica et biophysica acta, 433 1
McMullen (1971)
807Biochim. Biophys. Acta, 241
A. Burgess, S. Leach (1973)
Conformational studies on alamethicinBiopolymers, 12
E. Bayer, M. Mutter, R. Uhmann, J. Polster, H. Mauser (1974)
Kinetic studies of the liquid phase peptide synthesis.Journal of the American Chemical Society, 96 23
Boheim (1974)
277J. Membr. Biol., 19
D. Martin, R. Williams (1976)
Chemical nature and sequence of alamethicin.The Biochemical journal, 153 2
W. König, R. Geiger (1970)
Eine neue Methode zur Synthese von Peptiden: Aktivierung der Carboxylgruppe mit Dicyclohexylcarbodiimid unter Zusatz von 1‐Hydroxy‐benzotriazolenChemische Berichte, 103
N. Shamala, R. Nagaraj, P. Balaram (1977)
The crystal and molecular structure of the amino terminal tetrapeptide of alamethicin. A novel 310 helical conformation.Biochemical and biophysical research communications, 79 1
L. Carpino (1957)
Oxidative Reactions of Hydrazines. IV. Elimination of Nitrogen from 1,1-Disubstituted-2-arenesulfonhydrazides1-4Journal of the American Chemical Society, 79
G. Baumann, P. Mueller (1974)
A molecular model of membrane excitability.Journal of supramolecular structure, 2 5-6
(1971)
Hoppe - Seyler ’ s 2
G. Jung, N. Dubischar (1975)
Conformational changes of alamethicin induced by solvent and temperature. A 13C-NMR and circular-dichroism study.European journal of biochemistry, 54 2
M. Mutter (1977)
The influence of the macromolecular protecting group in conformational studies on polyoxyethylene-bound peptides.Macromolecules, 10 6
H. Rosenkranz, W. Scholtan (1971)
Eine verbesserte Methode zur Konformationsbestimmung von helicalen Proteinen aus Messungen des CirculardichroismusBiological Chemistry, 352
(1977)
Biopolymers 16,2591-2592
M. Nieto, H. Perkins (1971)
Modifications of the acyl-D-alanyl-D-alanine terminus affecting complex-formation with vancomycin.The Biochemical journal, 123 5
(1978)
Tetrahedron, in 119
G. Irmscher, G. Bovermann, G. Boheim, G. Jung (1978)
Trichotoxin A-40, a new membrane-exciting peptide. Part A. Isolation, characterization and conformationBiochimica et Biophysica Acta, 507
The stepwise synthesis and conformational studies of the N‐terminal helical partial sequence of the membrane‐modifying polypeptide antibiotic alamethicin are described. The polyoxyethylen esters of the fragments N‐t‐Boc‐L‐Pro‐Aib‐Ala‐Gln‐Aib‐Val‐Aib‐Gly‐OH and N‐Ac‐Aib‐L‐Pro‐Aib‐Ala‐Aib‐Ala‐Gln‐Aib‐Val‐Aib‐Gly‐OH are synthesized using polyoxyethylene (molecular mass 10,000) as solubilizing support. CD spectra of each intermediate in ethanol show α‐helix formation of the N‐protected peptide polymers beginning with the nonapeptide and of the N‐protonated sequences beginning with the decapeptide. Compared to the helix of alamethicin, temperature‐ and solvent‐dependent CD measurements indicate analogous conformational behavior. The results suggest that in lipophilic media the alamethicin helix can extend the full length of the partial sequence between the two proline residues and that aqueous media favor an increase of random‐coil conformation. For model studies of the particular lipid interaction of alamethicin, the stepwise synthesis of peptides with the alternating (Aib‐L‐Ala)n sequence (n = 1–7) was carried out on a polyoxyethylene support (molecular mass 6000). CD and ORD studies in ethanol showed a change from the random coil to a right‐handed α‐helix with increasing peptide length. This change is observed for the N‐protected peptides at a chain length of 8 residues and for the N‐protonated peptides at a length of 9 residues. The comparison of the CD data of free and polyoxyethylene‐bound peptides revealed that the solubilizing polymeric support cannot induce conformational changes. The intensities of the CD bands of t‐Boc‐(Aib‐L‐Ala)n‐OPOE (n ≥ 6) are higher than those of alamethicin, and these model peptides show similar temperature and solvent inducible changes of their helix contents.
Biopolymers – Wiley
Published: Feb 1, 1979
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.