Synthesis and Antibacterial Activity of 2‐substitued‐(3‐pyridyl)‐quinazolinone Derivatives

Synthesis and Antibacterial Activity of 2‐substitued‐(3‐pyridyl)‐quinazolinone Derivatives A series of 2‐substitued‐(3‐pyridyl)‐quinazolinone derivatives were synthesized, characterized, and evaluated for bacteriostatic activity against three species of phytopathogenic bacteria (Xanthomonas oryzae pv. oryzae, Xoo, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri, Xac). Biological evaluation showed that compounds 4b, 4g, 4h, 4l, and 4m exhibited higher antibacterial activity than bismerthiazol, the positive control, under conditions. In particular, compounds 4l and 4m exhibited significant bacteriostatic activity against Xac. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Heterocyclic Chemistry Wiley

Synthesis and Antibacterial Activity of 2‐substitued‐(3‐pyridyl)‐quinazolinone Derivatives

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Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
© 2018 Wiley Periodicals, Inc.
ISSN
0022-152X
eISSN
1943-5193
D.O.I.
10.1002/jhet.3099
Publisher site
See Article on Publisher Site

Abstract

A series of 2‐substitued‐(3‐pyridyl)‐quinazolinone derivatives were synthesized, characterized, and evaluated for bacteriostatic activity against three species of phytopathogenic bacteria (Xanthomonas oryzae pv. oryzae, Xoo, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri, Xac). Biological evaluation showed that compounds 4b, 4g, 4h, 4l, and 4m exhibited higher antibacterial activity than bismerthiazol, the positive control, under conditions. In particular, compounds 4l and 4m exhibited significant bacteriostatic activity against Xac.

Journal

Journal of Heterocyclic ChemistryWiley

Published: Jan 1, 2018

References

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