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A. Preston, A. Barr (1964)
The Plasma Concentration of Factor VIII in the Normal PopulationBritish Journal of Haematology, 10
C. Kasper, M. Hoag, P. Aggeler, S. Stone (1964)
Blood Clotting Factors in Pregnancy: Factor VIII Concentrations in Normal and AHF‐deficient WomenObstetrics & Gynecology, 24
Preston Ae (1964)
THE PLASMA CONCENTRATION OF FACTOR VIII IN THE NORMAL POPULATION. I. MOTHERS AND BABIES AT BIRTH.British Journal of Haematology, 10
Todd Me, Thompson Jh, Bowie Ej, Charles Owen (1965)
CHANGES IN BLOOD COAGULATION DURING PREGNANCY.Mayo Clinic proceedings, 40
H. Strauss, L. Diamond (1963)
ELEVATION OF FACTOR VIII (ANTIHEMOPHILIC FACTOR) DURING PREGNANCY IN NORMAL PERSONS AND IN A PATIENT WITH VON WILLEBRAND'S DISEASE.The New England journal of medicine, 269
(1975)
) . The NICHD National Registry f o r Amniocentesis
(1966)
Sex chromatin and antenatal sex diagnosis
S. Cederbaum, G. Holzman, R. Sparkes (1971)
"Spontaneous" abortion and haemorrhage following attempted amniocentesis in a carrier of haemophilia A.Lancet, 2 7721
(1975)
Unpublished data. National Institute of Child Health and Human Development
B. Bennett, O. Ratnoff (1972)
Changes in antihemophilic factor (AHF, factor 8) procoagulant activity and AHF-like antigen in normal pregnancy, and following exercise and pneumoencephalography.The Journal of laboratory and clinical medicine, 80 2
A study was designed to determine whether there is an increased risk of complications when amniocentesis for fetal sex determination is performed on hemophilia carriers. Questionnaires were sent to 112 medical centers providing this service in the United States, and to 19 outside the United States. Responses were received from 76 % of the centers in the United States. Data on 11,819 taps were obtained. Only 75 taps (0.64%) were performed for the indication of hemophilia. The frequency of fetal deaths in the general sample (1.84 %) was not significantly different from that in the subsample of hemophilia carriers (1.33 %). The results of this survey correspond very closely to data from a National Registry on amniocentesis for various indications in such variables as the number of taps needed for diagnosis, color of the fluid obtained, and number of dry taps. Carrier women who had bleeding problems during the monitored pregnancy are described. The problems might have been related to the amniocentesis in three women. It is calculated that only 2–4 % of hemophilia carrier women who might have amniocentesis are utilizing the service.
Clinical Genetics – Wiley
Published: Nov 1, 1976
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