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L. Backx, H. Esch, C. Melotte, N. Kosyakova, H. Starke, J. Frijns, T. Liehr, J. Vermeesch (2007)
Array painting using microdissected chromosomes to map chromosomal breakpointsCytogenetic and Genome Research, 116
R. Hastings, D. Nisbet, K. Waters, T. Spencer, L. Chitty (1999)
Prenatal detection of extra structurally abnormal chromosomes (ESACs): new cases and a review of the literaturePrenatal Diagnosis, 19
Sala (2005)
First report of a supernumerary marker chromosome 6Chromosome Res, 13
A. Snijders, N. Nowak, R. Segraves, S. Blackwood, Nils Brown, J. Conroy, G. Hamilton, A. Hindle, B. Huey, Karen Kimura, Sindy Law, K. Myambo, J. Palmer, B. Ylstra, J. Yue, J. Gray, Ajay Jain, D. Pinkel, D. Albertson (2001)
Assembly of microarrays for genome-wide measurement of DNA copy numberNature Genetics, 29
Bing Huang, S. Solomon, M. Thangavelu, K. Peters, S. Bhatt (2006)
Supernumerary marker chromosomes detected in 100 000 prenatal diagnoses: molecular cytogenetic studies and clinical significancePrenatal Diagnosis, 26
(2009)
ACOG Committee Opinion No. 446: array comparative genomic hybridization in prenatal diagnosis.Obstetrics and gynecology, 114 5
E. Hook, P. Cross (1987)
Extra structurally abnormal chromosomes (ESAC) detected at amniocentesis: frequency in approximately 75,000 prenatal cytogenetic diagnoses and associations with maternal and paternal age.American journal of human genetics, 40 2
B. Ballif, Sara Hornor, Scott Sulpizio, Richard Lloyd, Sara Minier, E. Rorem, A. Theisen, B. Bejjani, L. Shaffer (2007)
Development of a high-density pericentromeric region BAC clone set for the detection and characterization of small supernumerary marker chromosomes by array CGHGenetics in Medicine, 9
P. Benn, L. Hsu (1984)
Incidence and significance of supernumerary marker chromosomes in prenatal diagnosis.American journal of human genetics, 36 5
James Lu, Philippe Campeau, Brendan Lee (2014)
Genotype-Phenotype CorrelationObstetrical & Gynecological Survey, 69
J. Crolla, J. Harvey, F. Sitch, N. Dennis (1995)
Supernumerary marker 15 chromosomes: a clinical, molecular and FISH approach to diagnosis and prognosisHuman Genetics, 95
K. Rauen, D. Albertson, D. Pinkel, P. Cotter (2002)
Additional patient with del(12)(q21.2q22): further evidence for a candidate region for cardio-facio-cutaneous syndrome?American journal of medical genetics, 110 1
K. Brøndum‐Nielsen, M. Mikkelsen (1995)
A 10‐year survey, 1980–1990, of prenatally diagnosed small supernumerary marker chromosomes, identified by fish analysis. Outcome and follow‐up of 14 cases diagnosed in a series of 12 699 prenatal samplesPrenatal Diagnosis, 15
Ming Chen, Shun‐Ping Chang, Pao-Lun Yin, Mike Sapeta, S. Barringer, S. Kuo, Hon‐Tsen Yu, B. Wang (2006)
Prenatal identification of small supernumerary marker chromosomes by FISH in an infant born with mild congenital anomaliesPrenatal Diagnosis, 26
E. Sachs, J. Hemel, J. Hollander, M. Jahoda (1987)
Marker chromosomes in A series of 10000 prenatal diagnoses. Cytogenetic and follow‐up studiesPrenatal Diagnosis, 7
E. Blennow, T. Bui, U. Kristoffersson, M. Vujić, G. Annéren, E. Holmberg, M. Nordenskjöld (1994)
Swedish survey on extra structurally abnormal chromosomes in 39 105 consecutive prenatal diagnoses: Prevalence and characterization by fluorescence in situ hybridizationPrenatal Diagnosis, 14
H. Starke, A. Nietzel, A. Weise, A. Heller, K. Mrasek, Britta Belitz, C. Kelbova, M. Volleth, B. Albrecht, B. Mitulla, R. Trappe, I. Bartels, S. Adolph, A. Dufke, S. Singer, M. Stumm, R. Wegner, J. Seidel, A. Schmidt, A. Kuechler, I. Schreyer, U. Claussen, F. Eggeling, T. Liehr (2003)
Small supernumerary marker chromosomes (SMCs): genotype-phenotype correlation and classificationHuman Genetics, 114
J. Crolla, F. Long, H. Rivera, N. Dennis (1998)
FISH and molecular study of autosomal supernumerary marker chromosomes excluding those derived from chromosomes 15 and 22: I. Results of 26 new cases.American journal of medical genetics, 75 4
P. Cotter, K. Drexler, Amy Corley, S. Covert, Jessica Moland, I. Govberg, M. Norton (2005)
Prenatal Diagnosis of Minute Supernumerary Marker ChromosomesGynecologic and Obstetric Investigation, 60
K. Lichtenbelt, N. Knoers, G. Schuring-Blom (2011)
From Karyotyping to Array-CGH in Prenatal DiagnosisCytogenetic and Genome Research, 135
R. Leite, M. Souto, B. Carvalho, M. Martins, R. Chaves, Ângela Morais, H. Guedes‐Pinto, J. Wienberg, E. Ribeiro (2006)
Identification, characterization and clinical implications of two markers detected at prenatal diagnosisPrenatal Diagnosis, 26
B. Ballif, E. Rorem, K. Sundin, Matt Lincicum, S. Gaskin, J. Coppinger, C. Kashork, L. Shaffer, B. Bejjani (2006)
Detection of low‐level mosaicism by array CGH in routine diagnostic specimensAmerican Journal of Medical Genetics Part A, 140A
J. Crolla (1998)
FISH and molecular studies of autosomal supernumerary marker chromosomes excluding those derived from chromosome 15: II. Review of the literature.American journal of medical genetics, 75 4
Kendy Wong, R. deLeeuw, Nirpjit Dosanjh, Lindsey Kimm, Ze Cheng, D. Horsman, C. MacAulay, R. Ng, Carolyn Brown, E. Eichler, W. Lam (2007)
A comprehensive analysis of common copy-number variations in the human genome.American journal of human genetics, 80 1
O. Bartsch, Anne Loitzsch, P. Kozlowski, M-L Mazauric, G. Hickmann (2005)
Forty-two supernumerary marker chromosomes (SMCs) in 43 273 prenatal samples: chromosomal distribution, clinical findings, and UPD studiesEuropean Journal of Human Genetics, 13
Thomas Liehr, K. Mrasek, A. Weise, A. Dufke, L. Rodríguez, N. Guardia, A. Sanchis, J. Vermeesch, C. Ramel, A. Polityko, O. Haas, Jasen Anderson, U. Claussen, F. Eggeling, H. Starke (2005)
Small supernumerary marker chromosomes – progress towards a genotype-phenotype correlationCytogenetic and Genome Research, 112
R. James, I. Temple, N. Dennis, J. Crolla (1995)
A Search for Uniparental Disomy in Carriers of Supernumerary Marker ChromosomesEuropean Journal of Human Genetics, 3
T. Liehr, H. Starke, G. Senger, C. Melotte, A. Weise, J. Vermeesch (2006)
Overrepresentation of small supernumerary marker chromosomes (sSMC) from chromosome 6 origin in cases with multiple sSMCAmerican Journal of Medical Genetics Part A, 140A
Supernumerary marker chromosomes (SMC) are relatively common in prenatal diagnosis. As the clinical outcomes vary greatly, a better understanding of the karyotype–phenotype correlation for different SMCs will be important for genetic counseling. We present two cases of prenatally detected de novo, small SMCs. The markers were present in 80% of amniocyte colonies in Case 1 and 38% of the colonies in Case 2. The SMCs were determined to be derived from chromosome 6 during postnatal confirmation studies. Although the sizes and the chromosomal origin of the SMCs in these two cases appeared to be similar, the clinical outcomes varied. The clinical manifestations observed in Case 1 included small for gestational age, feeding difficulty at birth, hydronephrosis, deviated septum and dysmorphic features, while the phenotype is apparently normal in Case 2. Array comparative genomic hybridization (CGH) was performed and showed increase in dosage for approximately 26 Mb of genetic material from the proximal short and long arms of chromosome 6 in Case 1. Results of array CGH were uninformative in Case 2, either due to mosaicism or lack of detectable euchromatin. The difference in the clinical presentation in these two patients may have resulted from the difference in the actual gene contents of the marker chromosomes and/or the differential distribution of the mosaicism. © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part A – Wiley
Published: Jul 1, 2012
Keywords: ; ; ;
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