Loading next page...
/lp/wiley/substantia-nigra-6-hydroxydopamine-lesions-alter-dopaminergic-synaptic-6j8SNOLZar
- Publisher
- Wiley
- Copyright
- Copyright © 1989 Alan R. Liss, Inc.
- ISSN
- 0887-4476
- eISSN
- 1098-2396
- D.O.I.
- 10.1002/syn.890040310
- Publisher site
- See Article on Publisher Site
Abstract
Recent findings have demonstrated the existence of dopaminergic (DA) markers in the nbM of the human brain and a reduction of these markers in both the nbM and the striatum of patients suffering from Alzheimer's disease (AD). To investigate the source of the DA synaptic markers found in the nbM, rats received unilateral 6‐OHDA lesions of the substantia nigra pars compacta (SNc). The SNc lesions caused signigificant reductions in DA and DOPAC but not HVA in the nbM and the striaum; 3H‐sulpiride binding to D2 receptors ipsilateral to the SNc lesion was significantly increased in the stratum (16%), consistent with denervation supersensitivity, but single‐point analysis showed no significant changes in the nbM. These data suggest that the decreases in DA and 3H‐spiperone binding levels observed in the nbM of AD patients may be due to partial destruction of DA nbM afferent projections from the brainstem.
Journal
Synapse – Wiley
Published: Jan 1, 1989
Recommended Articles
Loading...
References
-
Changes in the brain catecholamines in patients with dementia of Alzheimer typeAdolfsson, Adolfsson; Gottfries, Gottfries; Roos, Roos; Winbland, Winbland
-
Changes of biogenic amines and their metabolites in postmortem brains from patients with Alzheimer‐type dementiaArai, Arai; Kosaba, Kosaba; Iizuka, Iizuka
-
Decreased CSF concentrations of homavanillic acid and gamma‐aminobutyric acid in Alzheimer's diseaseBareggi, Bareggi; Franceschi, Franceschi; Bonini, Bonini; Zecca, Zecca; Smirne, Smirne
-
Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysisBigl, Bigl; Woolf, Woolf; Butcher, Butcher
-
Connections of the median and dorsal raphe nuclei in the rat: An autoradiographic and degeneration studyConrad, Conrad; Leonard, Leonard; Pfaff, Pfaff
-
Nigrostriatal lesions enhance striatal 3H‐apomorphine and 3H‐spiroperidal bindingCreese, Creese; Snyder, Snyder
-
Striatal dopamine receptors in Alzheimer‐type dementiaCross, Cross; Crow, Crow; Ferrier, Ferrier; Johnson, Johnson; Markakis, Markakis
-
Magnocellular nuclei of the basal forebrain project to neocortex, brainstem and olfactory bulb. Review of some functional correlatesDivac, Divac
-
Long‐term effects of nigro‐striatal denervation on striatal 3H haloperidol bindingFeuerstein, Feuerstein; Demenge, Demenge; Barrette, Barrette; Silice, Silice; Guerin, Guerin; Mouchet, Mouchet
-
The identification of some sources of afferent input to the rat nucleus basalis magnocellularis by retrograde transport of horseradish peroxidaseHaring, Haring; Wang, Wang
-
Immunocytochemical identification of cholinergic neurons in the monkey central nervous system using monoclonal antibodies against choline acetyltransferaseHedreen, Hedreen; Bacon, Bacon; Cork, Cork; Kitt, Kitt; Crawford, Crawford; Salvaterra, Salvaterra; Price, Price
-
Topography of the magnocellular basal forebrain system in human brainHedreen, Hedreen; Struble, Struble; Whitehouse, Whitehouse; Price, Price
-
The relationship between loss of dopamine nerve terminals, striatal 3H spiroperidal binding and rotational behavior in unilaterally 6‐hydroxydopamine lesioned ratsHeikkila, Heikkila; Shapiro, Shapiro; Duvoisin, Duvoisin
-
The olfactory connections of the diencephalon in the rat: An experimental light and electron microscopic study with special emphasis on the problem of terminal degenerationHeimer, Heimer
-
Evidence for a cholinergic projection to neocortex from neurons in basal forebrainJohnson, Johnson; McKinney, McKinney; Coyle, Coyle
-
Basal forebrain innervation of rodent neocortex: Studies using acetylcholinesterase histochemistry, Golgi and lesion strategiesKristt, Kristt; McGowan, McGowan; Martin‐MacKinnon, Martin‐MacKinnon; Solomon, Solomon
-
The nucleus basalis magnocellularis: The origin of cholinergic projection to the neocortex of the ratLehmann, Lehmann; Nagy, Nagy; Atmadja, Atmadja; Fibiger, Fibiger
-
Protein measurement with folin phenol reagentLowry, Lowry; Rosenbraugh, Rosenbraugh; Farr, Farr; Randall, Randall
-
Changes in the monoamine containing neurones of the human CNS in senile dementiaMan, Man; Lincoln, Lincoln; Yates, Yates; Stamp, Stamp; Toper, Toper
-
Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's diseaseMann, Mann; Yates, Yates; Marcyniuk, Marcyniuk
-
Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic systemMcKinney, McKinney; Coyle, Coyle; Hedreen, Hedreen
-
Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferaseMesulam, Mesulam; Geula, Geula
-
Neural inputs into the nucleus basalis of the substantia innominata (Ch4) in the rhesus monkeyMesulam, Mesulam; Mufson, Mufson
-
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata) and hypothalamus in the rhesus monkeyMesulam, Mesulam; Mufson, Mufson; Levey, Levey; Wainer, Wainer
-
Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and actylcholinesterase histochemistryMesulam, Mesulam; Mufson, Mufson; Levey, Levey; Wainer, Wainer
-
Three‐dimensional representation and cortical projection topography of the nucleus basalis (Ch4) in the macaque: Concurrent demonstration of choline acetyltransferase and retrograde transport with a stabilized tetramethylbenzidine method for horseradish peroxidaseMesulam, Mesulam; Mufson, Mufson; Wainer, Wainer
-
Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1‐Ch6)Mesulam, Mesulam; Mufson, Mufson; Wainer, Wainer; Levey, Levey
-
Supersensitivity in rat caudate nucleus: Effects of 6‐hydroxydopamine on the time course of dopamine receptor and cyclic AMP changesMishra, Mishra; Marshall, Marshall; Varmuza, Varmuza
-
Dopaminergic supersensitivity after neuroleptics: Time‐course and specificityMuller, Muller; Seeman, Seeman
-
Catecholamine neurons with Alzheimer's neurofibrillary changes and alteration of tyrosine hydroxylaseNakashima, Nakashima; Ikuta, Ikuta
-
Locally applied dopamine alters activity of ventral pallidal substantia innominata cellsNapier, Napier; Breese, Breese
-
Neurons located in the ventral globus pallidus (substantia innominata) demonstrate an opomorphine‐induced increase in activity which is reversed by halloperidolNapier, Napier; Simson, Simson; Breese, Breese
-
Morphological characteristics of acetylcholinesterase containing neurons in the CNS of DFP‐treated monkeysParent, Parent; Poirier, Poirier; Boucher, Boucher; Butcher, Butcher
-
A radioautographic study of the efferent pathways of the nucleus locus coeruleusPickel, Pickel; Segal, Segal; Bloom, Bloom
-
An autoradiographic study of the projections of the central nucleus of the monkey amygdalaPrice, Price; Amaral, Amaral
-
The substantia innominata in Alzheimer's disease: An histochemical and biochemical study of cholinergic marker enzymesRossor, Rossor; Svendsen, Svendsen; Hunt, Hunt; Mountjoy, Mountjoy; Roth, Roth; Iversen, Iversen
-
Organization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleusSaper, Saper
-
A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistrySatoh, Satoh; Armstrong, Armstrong; Fibiger, Fibiger
-
Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry and electrophysiology in the ratSemba, Semba; Reiner, Reiner; McGeer, McGeer; Fibiger, Fibiger
-
Alzheimer's disease: Monoamines and spiperone binding reduced in nucleus basalisSparks, Sparks; Markesbery, Markesbery; Slevin, Slevin
-
Determination of tyrosine, tryptophan and their metabolic derivatives by liquid chromatographyelectrochemical detection: Application to post mortem samples from patients with Parkinson's and Alzheimer's diseaseSparks, Sparks; Slevin, Slevin
-
Dopamine receptor changes following destruction of the nigrostriatal pathway: Lack of a relationship to rotational behaviorStaunton, Staunton; Wolfe, Wolfe; Groves, Groves; Molinoff, Molinoff
-
Fine‐structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementiaSuzuki, Suzuki; Terry, Terry
-
A quantitative and ultrastructural study of substantia nigra and nucleus centralis superior in Alzheimer's diseaseTabaton, Tabaton; Shenone, Shenone; Ramagnoli, Ramagnoli; Mancardi, Mancardi
-
Senile dementia of the Alzheimer typeTerry, Terry; Katzman, Katzman
-
Specific binding of 3H spiperone to rat striatal preparationsTheodorou, Theodorou; Crockett, Crockett; Jenner, Jenner; Marsden, Marsden
-
Cation regulation differentiates specific binding of 3H sulpiride and 3H spiperone to rat striatal preparationsTheodorou, Theodorou; Hall, Hall; Jenner, Jenner; Marsden, Marsden
-
A comparison of the distribution of the fornix system in the rat, guinea pig, cat and monkeyValenstein, Valenstein; Nauta, Nauta
-
Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferaseWainer, Wainer; Levey, Levey; Mufson, Mufson; Mesulam, Mesulam
-
Catecholamines and cholinergic enzymes in pre‐senile and senile Alzheimer‐type dementia and Down's syndromeYates, Yates; Simpson, Simpson; Gordon, Gordon; Maloney, Maloney; Allison, Allison; Ritchie, Ritchie; Urqurehart, Urqurehart
@Phil_Robichaud
@deepthiw
@JoseServera