Substance P Inhibits the Release of Anterior Pituitary Adrenocorticotrophin via a Central Mechanism Involving Corticotrophin‐Releasing Factor‐Containing Neurons in the Hypothalamic Paraventricular Nucleus

Substance P Inhibits the Release of Anterior Pituitary Adrenocorticotrophin via a Central... Chronic osmotic stimulation influences the hypothalamo‐adenohypophysial axis by inhibiting the synthesis of hypothalamic corticotrophin‐releasing factor (CRF‐41) and subsequently the secretion of basal and adrenalectomy‐elevated adrenocorticotrophin from the adenohypophysis. In the present study, we used a substance P antagonist to test the hypothesis that this inhibition is mediated centrally by substance P or other tachykinins. In control rats and rats given 2% saline to drink for 12 days, intracerebroventricular administration of a substance P antagonist elevated plasma adrenocorticotrophin and corticosterone levels. Using quantitative in situ hybridization histochemistry, it was also demonstrated that CRF mRNA increased in the medial parvocellular division of the paraventricular nucleus of saline‐treated as well as control rats 6 h after intracerebroventricular administration of the antagonist, while vasopressin mRNA in the medial parvocellular division of the paraventricular nucleus was increased in the control animals only. These results provide evidence that central endogenous substance P has an inhibitory influence over the synthesis and release of CRF‐41 both under normal conditions and during a chronic osmotic stimulus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neuroendocrinology Wiley

Substance P Inhibits the Release of Anterior Pituitary Adrenocorticotrophin via a Central Mechanism Involving Corticotrophin‐Releasing Factor‐Containing Neurons in the Hypothalamic Paraventricular Nucleus

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Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0953-8194
eISSN
1365-2826
DOI
10.1111/j.1365-2826.1993.tb00368.x
Publisher site
See Article on Publisher Site

Abstract

Chronic osmotic stimulation influences the hypothalamo‐adenohypophysial axis by inhibiting the synthesis of hypothalamic corticotrophin‐releasing factor (CRF‐41) and subsequently the secretion of basal and adrenalectomy‐elevated adrenocorticotrophin from the adenohypophysis. In the present study, we used a substance P antagonist to test the hypothesis that this inhibition is mediated centrally by substance P or other tachykinins. In control rats and rats given 2% saline to drink for 12 days, intracerebroventricular administration of a substance P antagonist elevated plasma adrenocorticotrophin and corticosterone levels. Using quantitative in situ hybridization histochemistry, it was also demonstrated that CRF mRNA increased in the medial parvocellular division of the paraventricular nucleus of saline‐treated as well as control rats 6 h after intracerebroventricular administration of the antagonist, while vasopressin mRNA in the medial parvocellular division of the paraventricular nucleus was increased in the control animals only. These results provide evidence that central endogenous substance P has an inhibitory influence over the synthesis and release of CRF‐41 both under normal conditions and during a chronic osmotic stimulus.

Journal

Journal of NeuroendocrinologyWiley

Published: Feb 1, 1993

References

  • Substance P and neurotensin: their roles in the regulation of anterior pituitary function
    Aronin, Aronin; Coslovsky, Coslovsky; Leeman, Leeman
  • Vasopressin, oxytocin, dynorphin, enkephalin and corticotrophin‐releasing factor mRNA stimulation in the rat
    Lightman, Lightman; Young, Young
  • Autonomic, sensory, and motor dysfunction following intrathecal administration of three substance P antagonists
    Cox, Cox; Schelper, Schelper; Farachi, Farachi; Brody, Brody
  • Hypothalamic integration: organization of the paraventricular and supraoptic nuclei
    Swanson, Swanson; Sawchenko, Sawchenko
  • Biological evaluation of substance P antagonists
    Folkers, Folkers; Hakanson, Hakanson; Horig, Horig; Cheng, Cheng; Leander, Leander

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