Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various... The effect of the 5‐hydroxytryptamine (5‐HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)‐ or muscimol‐injected rats. Sibutramine dose‐dependently reduced feeding caused by food‐deprivation (ED50=5.1±0.8 mg kg−1) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50=6.0±0.5 mg kg−1). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1–10 mg kg−1). The hypophagic effect of 5.1 mg kg−1 sibutramine in food‐deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non‐selective, 0.3 and 1.0 mg kg−1), ritanserin (5‐HT2A/2C, 0.5 and 1.0 mg kg−1) and GR127935 (5‐HT1B/1D, 0.5 and 1.0 mg kg−1) did not modify the hypophagic effect of sibutramine, while SB206553 (5‐HT2B/2C, 5 and 10 mg kg−1) slightly but significantly reduced it (Fint(2.53)=3.4; P<0.05). The reduction in food intake caused by 6.0 mg kg−1 sibutramine in NPY‐injected rats was not modified by GR127935 (1.0 mg kg−1). The results suggest that, with the possible exception of a partial involvement of 5‐HT2B/2C receptors in sibutramine's hypophagia in food‐deprived rats, 5‐HT1 and 5‐HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2 h after injection. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

Loading next page...
 
/lp/wiley/studies-on-the-role-of-serotonin-receptor-subtypes-in-the-effect-of-7RAbNy3rV0
Publisher
Wiley
Copyright
"Copyright © 1999 Wiley Subscription Services, Inc., A Wiley Company"
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1038/sj.bjp.0702633
Publisher site
See Article on Publisher Site

Abstract

The effect of the 5‐hydroxytryptamine (5‐HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)‐ or muscimol‐injected rats. Sibutramine dose‐dependently reduced feeding caused by food‐deprivation (ED50=5.1±0.8 mg kg−1) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50=6.0±0.5 mg kg−1). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1–10 mg kg−1). The hypophagic effect of 5.1 mg kg−1 sibutramine in food‐deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non‐selective, 0.3 and 1.0 mg kg−1), ritanserin (5‐HT2A/2C, 0.5 and 1.0 mg kg−1) and GR127935 (5‐HT1B/1D, 0.5 and 1.0 mg kg−1) did not modify the hypophagic effect of sibutramine, while SB206553 (5‐HT2B/2C, 5 and 10 mg kg−1) slightly but significantly reduced it (Fint(2.53)=3.4; P<0.05). The reduction in food intake caused by 6.0 mg kg−1 sibutramine in NPY‐injected rats was not modified by GR127935 (1.0 mg kg−1). The results suggest that, with the possible exception of a partial involvement of 5‐HT2B/2C receptors in sibutramine's hypophagia in food‐deprived rats, 5‐HT1 and 5‐HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2 h after injection.

Journal

British Journal of PharmacologyWiley

Published: Jul 1, 1999

Keywords: ; ; ; ; ;

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off