Structure and assembly of hemidesmosomes

Structure and assembly of hemidesmosomes The hemidesmosome is a complex junction containing many proteins. The keratin cytoskeleton attaches to its cytoplasmic plaque, while its transmembrane elements interact with components of the extracellular matrix. Hemidesmosome assembly involves recruitment of α6β4 integrin heterodimers, as well as cytoskeletal elements and cytoskeleton‐associated proteins to the cell surface. In our cell culture models, these phenomena appear to be triggered by laminin‐5 in the extracellular matrix. Cell interaction with laminin‐5 apparently induces both phosphorylation and dephosphorylation of subunits of α6β4 integrin. There is emerging evidence that such events are necessary for subsequent cytoskeleton anchorage to the hemidesmosome cytoplasmic plaque. Once assembled, the hemidesmosome plays an essential role in maintaining firm epithelial adhesion to the basement membrane, with hemidesmosome disruption being a hallmark of certain devastating blistering diseases. However, the hemidesmosome is more than just a stable anchor, as it may also be the site of signal transduction, mediated by its α6β4 integrin component. This review discusses our current knowledge of the structure and assembly of the hemidesmosome. BioEssays 20:488–494, 1998. © 1998 John Wiley & Sons, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioEssays Wiley

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Publisher
Wiley
Copyright
Copyright © 1998 John Wiley & Sons, Inc.
ISSN
0265-9247
eISSN
1521-1878
DOI
10.1002/(SICI)1521-1878(199806)20:6<488::AID-BIES7>3.0.CO;2-I
pmid
9699461
Publisher site
See Article on Publisher Site

Abstract

The hemidesmosome is a complex junction containing many proteins. The keratin cytoskeleton attaches to its cytoplasmic plaque, while its transmembrane elements interact with components of the extracellular matrix. Hemidesmosome assembly involves recruitment of α6β4 integrin heterodimers, as well as cytoskeletal elements and cytoskeleton‐associated proteins to the cell surface. In our cell culture models, these phenomena appear to be triggered by laminin‐5 in the extracellular matrix. Cell interaction with laminin‐5 apparently induces both phosphorylation and dephosphorylation of subunits of α6β4 integrin. There is emerging evidence that such events are necessary for subsequent cytoskeleton anchorage to the hemidesmosome cytoplasmic plaque. Once assembled, the hemidesmosome plays an essential role in maintaining firm epithelial adhesion to the basement membrane, with hemidesmosome disruption being a hallmark of certain devastating blistering diseases. However, the hemidesmosome is more than just a stable anchor, as it may also be the site of signal transduction, mediated by its α6β4 integrin component. This review discusses our current knowledge of the structure and assembly of the hemidesmosome. BioEssays 20:488–494, 1998. © 1998 John Wiley & Sons, Inc.

Journal

BioEssaysWiley

Published: Jun 1, 1998

References

  • Hemidesmosomes: Role in adhesion, signaling and human diseases
    Borradori, Borradori; Sonnenberg, Sonnenberg
  • Formation of hemidesmosomes in vitro by a rat bladder cell line
    Riddelle, Riddelle; Green, Green; Jones, Jones
  • Molecular genetic studies of a human epidermal autoantigen (the 180‐kD bullous pemphigoid antigen/BP180): Identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrin
    Hopkinson, Hopkinson; Baker, Baker; Jones, Jones
  • Immunochemical characterization of three components of the hemidesmosome and their expression in cultured epithelial cells
    Klatte, Klatte; Kurpakus, Kurpakus; Grelling, Grelling; Jones, Jones
  • A truncated laminin chain homologous to the B2 chain: Structure, spatial expression, and chromosomal assignment
    Kallunki, Kallunki; Sainio, Sainio; Eddy, Eddy; Byers, Byers; Kallunki, Kallunki; Sariola, Sariola; Beck, Beck; Hirvonen, Hirvonen; Shows, Shows; Tryggvason, Tryggvason
  • Kalinin: An epithelium‐specific basement membrane adhesion molecule that is a component of anchoring filaments
    Rousselle, Rousselle; Lunstrum, Lunstrum; Keene, Keene; Burgeson, Burgeson
  • Coating of titanium alloy with soluble laminin‐5 promotes cell attachment and hemidesmosome assembly in gingival epithelial cells: Potential application to dental implants
    Tamura, Tamura; Oda, Oda; Quaranta, Quaranta; Plopper, Plopper; Lambert, Lambert; Glaser, Glaser; Jones, Jones
  • Human amnion contains a novel laminin variant, laminin‐7, which like laminin‐6, covalently associates with laminin‐5 to promote stable epithelial‐stromal attachment
    Champliaud, Champliaud; Lunstrum, Lunstrum; Rousselle, Rousselle; Nishiyama, Nishiyama; Keene, Keene; Burgeson, Burgeson
  • Morphogenetic effects of soluble laminin‐5 on cultured epithelial cells and tissue explants
    Baker, Baker; DiPasquale, DiPasquale; Stock, Stock; Plopper, Plopper; Quaranta, Quaranta; Fitchmun, Fitchmun; Jones, Jones
  • Laminin‐5 inhibits human keratinocyte migration
    O'Toole, O'Toole; Marinkovich, Marinkovich; Hoeffler, Hoeffler; Furthmayr, Furthmayr; Woodley, Woodley
  • Laminin‐5 deposition promotes keratinocyte motility
    Zhang, Zhang; Kramer, Kramer
  • Processing of laminin‐5 and its functional consequences: Role of plasmin and tissue‐type plasminogen activator
    Goldfinger, Goldfinger; Stack, Stack; Jones, Jones

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