Structure and applications of organotin complex based on
trimethyltin cation and quinaldic acid
Mohamed M. El‐bendary
| Safaa El‐din H. Etaiw
Chemistry Department, Faculty of
Science, University of Jeddah, Jeddah,
Chemistry Department, Faculty of
Science, Tanta University, Tanta, Egypt
Mohamed M. El‐bendary, Chemistry
Department, Faculty of Science,
University of Jeddah, Jeddah, Saudi
The reaction between aqueous solution of Me
SnCl and acetonitrile solution of
quinaldic acid (quinH) at room temperature affords a new organotin complex,
O(1). Complex 1 was structurally characterized
using infrared, UV–visible and NMR spectra, thermogravimetric analysis and
single‐crystal X‐ray analysis. The network structure of 1 is developed by a lim-
itless number of discrete mononuclear molecules forming a one‐dimensional
chain via hydrogen bonds. Extensive hydrogen bonds and π–π stacking associ-
ate the one‐dimensional chains creating a two‐dimensional array. The two‐
dimensional arrays are additionally associated via hydrogen bonds through
the water molecules and the methyl groups forming a three‐dimensional
network. The cytotoxic impact of 1 on the viability of MCF‐7 cells was also
examined using MTT assay, exhibiting great inhibiting action against MCF‐7
cells. Furthermore, the catalytic degradation performance of 1 towards methy-
lene blue dye in the presence of H
as oxidant was investigated. The reaction
is first order with respect to methylene blue dye.
catalytic activity, in vitro cytotoxicity, organotin complex, quinaldic acid, spectra
1 | INTRODUCTION
Organotin complexes have attracted much consideration
attributable to their properties, structural chemistry and
potential applications in numerous scientific areas.
Among the many potential applications are in gas
as cytotoxic agents
and in chemical cataly-
as well as their industrial and agricultural applica-
One of the applications of organotin compounds
is their use as anticancer agents.
properties of organotin carboxylates have been investi-
gated for their anti‐tumour activity.
In general, the
biocidal activity of organotin complexes is greatly
influenced by the structure of the molecule and the coor-
dination number of the tin atoms.
dicarboxylates have been examined in extensive detail,
and in general the reported organotin(IV) dicarboxylates
exist as dinuclear
one‐dimensional zigzag chains
and cyclic structures.
complexes have been found to have anticancer activity
in a variety of tumour cells; however, triorganotin(IV)
compounds show a bigger cluster of anticancer action
than their di‐ and mono‐organotin(IV) analogues due to
their ability to bind proteins.
carboxylates have an extensive variety of potential
activities of carboxylates with respect to their parent
organotin(IV) precursors and the free carboxylic acid
ligands give the impression of being an added substance
(not a synergistic) effect of the metal ions and the carbox-
ylate groups. Biological activity is by and large connected
to the nature of the ligand
which encourages the
transportation of the complexes over the cell membrane.
It has been realized that the rigidity of a molecule not only
Received: 31 July 2017 Revised: 25 September 2017 Accepted: 26 September 2017
Appl Organometal Chem. 2018;32:e4152.
Copyright © 2017 John Wiley & Sons, Ltd.wileyonlinelibrary.com/journal/aoc 1of12